1-hexadecanoyl-sn-glycero-3-phosphocholine

Three steps

• CHEBI:15650Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 32 morecytosolOne of 2 routes

• CHEBI:15727Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 1 morecytosol

• CHEBI:15746Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 2 morecytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)
  3. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)

  Catalysed by ENPP2, GDPD3, GDPD1, DHRS7B and 1 moreperoxisomeOne of 2 routes

• 1-acylglycerone 3-phosphateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  3. aldo-keto reductase (1-acylglycerol-3P pool)

  Catalysed by ENPP2, GDPD3, GDPD1, AKR1A1cytosol

• CHEBI:15971Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and histidine (cytosol to extracellular)

  Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7 and 1 moreextracellular space, cytosol

• CHEBI:16108Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)
  2. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  3. sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase

  Catalysed by PLA2G6, LYPLA1, LYPLA2, PLA2G4B and 15 morecytosol, mitochondrial matrixOne of 2 routes

• cholesterolReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (9Z-octadecenoate) + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)

  Catalysed by LPCAT3, MBOAT1, MBOAT2, LPCAT2 and 7 moreOne of 2 routes

• hexadecan-1-olReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  3. hexadecanoyl-CoA + 2 NADPH + 2 H(+) = hexadecan-1-ol + 2 NADP(+) + CoA

  Catalysed by LPCAT3, MBOAT1, MBOAT2, LPCAT2 and 4 more

• sulfateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7 and 1 moreextracellular space, cytosol

• 11-cis-retinyl hexadecanoateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  3. 11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA

  Catalysed by LPCAT3, MBOAT1, MBOAT2, LPCAT2 and 3 moreOne of 4 routes

• a 1-O-alkyl-2-acetyl-sn-glycerolReach from here →
  1. a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-sn-glycero-3-phosphocholine
  2. a 1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
  3. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase

  Catalysed by LCAT, LPCAT4, LPCAT2, LPCAT1 and 2 morecytosolOne of 2 routes

• 11-cis-retinolReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
  2. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine
  3. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)

  Catalysed by PRDX6, LPCAT3, LPCAT1, LRAT and 1 moreOne of 2 routes

• cob(II)alaminReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 more

• phosphatidic acidReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  3. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by ENPP2, GDPD3, GDPD1, AGPAT2 and 8 morecytosol, mitochondrial matrixOne of 8 routes

• iodideReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7 and 1 moreextracellular space, cytosolOne of 23 routes

• L-valineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7 and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:16436Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  3. ceramide cholinephosphotransferase (CDP-choline)

  Catalysed by PRDX6, LPCAT3, LPCAT1, SGMS2endoplasmic reticulumOne of 3 routes

• oxaloacetateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 1 morecytosol

• L-arginineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7 and 1 moreextracellular space, cytosolOne of 2 routes

• nitric oxideReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 more

• N(2)-acetyl-L-ornithineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by LPCAT2, LPCAT1, PLA2G7, ACY1cytosol

• 3'-deoxy-3',4'-didehydro-CTPReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 more

• (S)-2-hydroxyglutarateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 more

• CHEBI:16856Reach from here →
  1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by LPCAT3, MBOAT7, PLA2G6, PLA2G1B and 11 moreextracellular space, cytosolOne of 4 routes

• CHEBI:16857Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7 and 1 moreextracellular space, cytosol

• oxalic acidReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7 and 1 moreextracellular space, cytosol

• a cholesterol esterReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (9Z-octadecenoate) + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion

  Catalysed by LPCAT3, MBOAT1, MBOAT2, LPCAT2 and 2 moreendoplasmic reticulumOne of 6 routes

• octadecanalReach from here →
  1. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  3. octadecanal + NAD(+) + H2O = octadecanoate + NADH + 2 H(+)

  Catalysed by LPCAT3, PLAAT3, ALDH3A2

• (R)-3-hydroxybutyric acidReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
  3. transport of (R)-3-hydroxybutanoate and acetate (cytosol to extracellular)

  Catalysed by LPCAT2, LPCAT1, PLA2G7, SLC16A4 and 3 moreextracellular space, cytosolOne of 2 routes

• L-isoleucineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7 and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:17203Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7 and 2 moreextracellular space, cytosolOne of 2 routes

• 17alpha-hydroxyprogesteroneReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by LPCAT2, LPCAT1, PLA2G7, CYP17A1endoplasmic reticulum

• anilineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 2 morecytosol

• CHEBI:17312Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by ENPP2, GDPD3, GDPD1, CHATcytosolOne of 2 routes

• 5'-deoxyadenosineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 moreOne of 4 routes

• all-trans-retinolReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
  2. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine
  3. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)

  Catalysed by PRDX6, LPCAT3, LPCAT1, LRAT and 3 more

• linoleic acidReach from here →
  1. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. Steryl-ester acylhydrolase

  Catalysed by LPCAT3, MBOAT2, LPCAT1, LCAT and 2 morelysosomeOne of 2 routes

• D-glyceraldehydeReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)
  2. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  3. glycerol + NADP(+) = D-glyceraldehyde + NADPH + H(+)

  Catalysed by PLA2G6, LYPLA1, LYPLA2, PLA2G4B and 16 more

• a monoacylglycerolReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)
  2. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  3. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)

  Catalysed by PLA2G6, LYPLA1, LYPLA2, PLA2G4B and 15 more

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  3. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA

  Catalysed by LPCAT3, MBOAT1, MBOAT2, LPCAT2 and 5 more

• L-cysteineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 1 morecytosol, mitochondrial matrixOne of 3 routes

• 3,3',5'-triiodo-L-thyronine sulfateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 more

• 3,3'-diiodo-L-thyronineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 2 moreOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 moreOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 3 morecytosol, mitochondrial matrix

• glycine betaineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline dehydrogenase (choline)
  3. p-cumic alcohol:NAD+ oxidoreductase

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 morecytosolOne of 7 routes

• 4-methylumbelliferyl acetateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by LPCAT2, LPCAT1, PLA2G7, CES2 and 2 more

• CHEBI:17895Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7 and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:17927Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by ENPP2, GDPD3, GDPD1, CHATcytosol