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Proteins/UNIPROT:Q7L5L3
Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylcholine (lyso-PC) and N-acylethanolamine lysophospholipids. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine..
Function from UniProtKB (Q7L5L3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
16 statements
16 statements · 5 reference databases · Subject: GDPD3 · Sources: Bgee, Hetionet, Reactome, Rhea, WikiPathways
7 reactions
1-hexadecanoyl-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphate+choline+hydron
Catalysed by ENPP2 or GDPD3 or GDPD1
Reaction pageLeft to rightBalanced
Rhea RHEA:38975CC BY 4.0Reference data
1-hexadecanoyl-sn-glycero-3-phosphocholine+watersn-glycerol 3-phosphocholine+hexadecanoate+
3 names
Resolves to: GDPD3
Catalysed by PLA2G6 or LYPLA1 or LYPLA2 or PLA2G4B or LIPC or CEL or PLA2G4A or PLA2G4E or PLA2G4F or PLB1 or PNPLA7 or GDPD3 and 5 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:40435CC BY 4.0Reference data
1-O-hexadecyl-sn-glycero-3-phosphocholine+water1-O-hexadecyl-sn-glycero-3-phosphate+choline+hydron
Catalysed by ENPP2 or GDPD3 or GDPD1
Reaction pageLeft to rightBalanced
Rhea RHEA:41143CC BY 4.0Reference data
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+waterN-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine+1-(9Z-octadecenoyl)-sn-glycero-3-phosphate+hydron
Catalysed by NAPEPLD or GDPD3 or GDPD1
Reaction pageLeft to rightBalanced
Rhea RHEA:45544CC BY 4.0Reference data
N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+waterN-hexadecanoylethanolamine+1-(9Z-octadecenoyl)-sn-glycero-3-phosphate+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:53168CC BY 4.0Reference data
1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine+water1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate+N-hexadecanoylethanolamine+hydron
Catalysed by GDPD3 or GDPD1 or GDE1
Reaction pageLeft to rightBalanced
Rhea RHEA:53184CC BY 4.0Reference data
N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+waterN-(9Z-octadecenoyl) ethanolamine+1-(9Z-octadecenoyl)-sn-glycero-3-phosphate+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:56460CC BY 4.0Reference data