5-oxo-L-proline

Three steps

• choloyl-CoAReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. cholate + ATP + CoA = choloyl-CoA + AMP + diphosphate

  Catalysed by CHAC2, CHAC1, ABCC4, SLC27A5inner side of the membrane, outer side of the membrane

• prostaglandin E1Reach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of prostaglandin E1 (cytosol to extracellular)

  Catalysed by CHAC2, CHAC1, PTGES, LANCL1 and 3 moreextracellular space, cytosolOne of 2 routes

• prostaglandin I2Reach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of prostaglandin I2 (cytosol to extracellular)

  Catalysed by CHAC2, CHAC1, PTGES, LANCL1 and 3 moreextracellular space, cytosolOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by CHAC2, CHAC1, PTGES, LANCL1 and 3 moreextracellular space, cytosolOne of 2 routes

• prostaglandin H2Reach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of prostaglandin H2 (cytosol to extracellular)

  Catalysed by CHAC2, CHAC1, PTGES, LANCL1 and 3 moreextracellular space, cytosolOne of 2 routes

• prostaglandin D2Reach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of prostaglandin D2 (cytosol to extracellular)

  Catalysed by CHAC2, CHAC1, PTGES, LANCL1 and 3 moreextracellular space, cytosolOne of 2 routes

• 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
  3. (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NADP+ 15-oxidoreductase

  Catalysed by CHAC2, CHAC1, GPX1, GPX2 and 1 morecytosolOne of 3 routes

• leukotriene A4Reach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. leukotriene C4 = leukotriene A4 + glutathione

  Catalysed by CHAC2, CHAC1, MGST3, GSTM4 and 2 moreOne of 3 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by CHAC2, CHAC1, TSTD1, MPST

• L-methionineReach from here →
  1. epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine
  2. epsilon-(gamma-L-Glutamyl)-L-lysine[c] = 5-oxoproline[c] + lysine[c]
  3. transport of lysine and methionine (cytosol to extracellular)

  Catalysed by GGACT, SLC7A6cytosol, extracellular spaceOne of 2 routes

• dehydroepiandrosterone 3-sulfateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by CHAC2, CHAC1, PTGES, LANCL1 and 3 moreextracellular space, cytosolOne of 2 routes

• L-tryptophanReach from here →
  1. epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine
  2. epsilon-(gamma-L-Glutamyl)-L-lysine[c] = 5-oxoproline[c] + lysine[c]
  3. transport of lysine and tryptophan (cytosol to extracellular)

  Catalysed by GGACT, SLC7A6cytosol, extracellular spaceOne of 2 routes

• L-saccharopineReach from here →
  1. epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine
  2. epsilon-(gamma-L-Glutamyl)-L-lysine[c] = 5-oxoproline[c] + lysine[c]
  3. N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)

  Catalysed by GGACT, AASScytosol, mitochondrial matrixOne of 2 routes

• L-alanineReach from here →
  1. epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine
  2. epsilon-(gamma-L-Glutamyl)-L-lysine[c] = 5-oxoproline[c] + lysine[c]
  3. transport of alanine and lysine (cytosol to extracellular)

  Catalysed by GGACT, SLC7A6cytosol, extracellular spaceOne of 3 routes

• L-asparagineReach from here →
  1. epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine
  2. epsilon-(gamma-L-Glutamyl)-L-lysine[c] = 5-oxoproline[c] + lysine[c]
  3. transport of asparagine and lysine (cytosol to extracellular)

  Catalysed by GGACT, SLC7A6cytosol, extracellular spaceOne of 2 routes

• L-phenylalanineReach from here →
  1. epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine
  2. epsilon-(gamma-L-Glutamyl)-L-lysine[c] = 5-oxoproline[c] + lysine[c]
  3. transport of lysine and phenylalanine (cytosol to extracellular)

  Catalysed by GGACT, SLC7A6cytosol, extracellular spaceOne of 2 routes

• 6-amino-2-oxohexanoateReach from here →
  1. epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine
  2. epsilon-(gamma-L-Glutamyl)-L-lysine[c] = 5-oxoproline[c] + lysine[c]
  3. L-lysine:oxygen 2-oxidoreductase (deaminating)

  Catalysed by GGACTcytosol, peroxisome

• taurolithocholate 3-sulfateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by CHAC2, CHAC1, PTGES, LANCL1 and 4 moreextracellular space, cytosolOne of 2 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine
  2. epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine
  3. N(omega),N(omega)-dimethyl-L-arginine(in) + L-lysine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-lysine(in)

  Catalysed by GGACT, SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)

  Catalysed by CHAC2, CHAC1, SQOR, PRODH2

• histamineReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of histamine (cytosol to extracellular)

  Catalysed by CHAC2, CHAC1, PTGES, LANCL1 and 4 moreextracellular space, cytosolOne of 2 routes

• L-thyroxineReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by CHAC2, CHAC1, PTGES, LANCL1 and 4 moreextracellular space, cytosolOne of 2 routes

• monodehydro-L-ascorbate radicalReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
  3. dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by CHAC2, CHAC1, CLIC1, GSTO1 and 2 moreOne of 11 routes

• dopamineReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of dopamine (cytosol to extracellular)

  Catalysed by CHAC2, CHAC1, PTGES, LANCL1 and 4 moreextracellular space, cytosolOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by CHAC2, CHAC1, PTGES, LANCL1 and 4 moreextracellular space, cytosolOne of 2 routes

• L-prolineReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)

  Catalysed by CHAC2, CHAC1, SQOR, PRODH and 1 more

• estrone 3-sulfateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by CHAC2, CHAC1, PTGES, LANCL1 and 3 moreextracellular space, cytosolOne of 2 routes

• prostaglandin E2Reach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of prostaglandin E2 (cytosol to extracellular)

  Catalysed by CHAC2, CHAC1, PTGES, LANCL1 and 4 moreextracellular space, cytosolOne of 2 routes

• leukotriene D4Reach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. leukotriene C4 + H2O = leukotriene D4 + L-glutamate

  Catalysed by CHAC2, CHAC1, MGST3, GSTM4 and 4 more

• 3-demethylubiquinol-10Reach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10
  3. 3-demethylubiquinol-10 + S-adenosyl-L-methionine = ubiquinol-10 + S-adenosyl-L-homocysteine + H(+)

  Catalysed by CHAC2, CHAC1, SQOR, COQ3

• (R)-noradrenalineReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
  3. dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by CHAC2, CHAC1, CLIC1, GSTO1 and 2 moreOne of 3 routes

• CHEBI:730073Reach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. Peroxidase

  Catalysed by CHAC2, CHAC1, SLC22A13, MPOinner side of the membrane, outer side of the membrane, nucleusOne of 3 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5

  Catalysed by CHAC2, CHAC1, PTGES, LANCL1 and 3 moreextracellular space, cytosolOne of 2 routes

• ursodeoxycholateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by CHAC2, CHAC1, PTGES, LANCL1 and 4 moreextracellular space, cytosolOne of 2 routes

• prostaglandin G2Reach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of prostaglandin G2 (cytosol to extracellular)

  Catalysed by CHAC2, CHAC1, PTGES, LANCL1 and 3 moreextracellular space, cytosolOne of 2 routes

• an alkyl sulfateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
  3. an alcohol + 3'-phosphoadenylyl sulfate = an alkyl sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by CHAC2, CHAC1, CP, PRDX6 and 3 more

• thromboxane B2Reach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by CHAC2, CHAC1, PTGES, LANCL1 and 3 moreextracellular space, cytosolOne of 2 routes

• (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
  3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O

  Catalysed by CHAC2, CHAC1, PTGES, MGST3 and 5 more

• (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
  3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by CHAC2, CHAC1, PTGES, MGST3 and 5 more

• (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
  3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by CHAC2, CHAC1, PTGES, MGST3 and 5 more