L-phenylalanine

1. Transport of L-Kynurenine
2. 2-oxohexanoate + L-kynurenine = L-2-aminohexanoate + kynurenate + H2O

Catalysed by SLC7A8, AADATextracellular space, cytosol

1. transport of arginine and phenylalanine (cytosol to extracellular)
2. L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)

Catalysed by SLC7A6, IL4I1extracellular space, cytosol

1. transport of cysteine and phenylalanine (cytosol to extracellular)
2. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

Catalysed by SLC7A5, CARS2extracellular space, cytosol

1. transport of phenylalanine and tryptophan (cytosol to extracellular)
2. L-tryptophan + O2 = N-formyl-L-kynurenine

Catalysed by SLC7A5, IDO1, TDO2, IDO2extracellular space, cytosolOne of 2 routes

1. Transport of L-Kynurenine
2. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O

Catalysed by SLC7A8, AADATextracellular space, cytosol

1. transport of glutamine and phenylalanine (cytosol to extracellular)
2. phosphoribosyl pyrophosphate amidotransferase (glutamine)

Catalysed by SLC7A5, PPATextracellular space, cytosolOne of 2 routes

1. transport of glutamine and phenylalanine (cytosol to extracellular)
2. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

Catalysed by SLC7A5, GFPT2, GFPT1extracellular space, cytosol

1. transport of methionine and phenylalanine (cytosol to extracellular)
2. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

Catalysed by SLC7A5, MSRAextracellular space, cytosol

1. transport of methionine and phenylalanine (cytosol to extracellular)
2. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

Catalysed by SLC7A5, MSRB3, MSRB1, MSRB2extracellular space, cytosol

1. transport of ornithine and phenylalanine (cytosol to extracellular)
2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

Catalysed by SLC7A6, AGXT2extracellular space, cytosolOne of 2 routes

1. transport of glycine and phenylalanine (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

Catalysed by SLC7A5, GLYATL2extracellular space, cytosolOne of 2 routes

1. transport of cysteine and phenylalanine (cytosol to extracellular)
2. (R)-4'-phosphopantothenate:L-cysteine ligase

Catalysed by SLC7A5, PPCSextracellular space, cytosolOne of 4 routes

1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

Catalysed by PAH, TPH1, TPH2One of 3 routes

1. Transport of L-Kynurenine
2. an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)

Catalysed by SLC7A8, SLC7A11extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

1. Transport of L-Phenylalanine by Atb0 Transporter
2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

Catalysed by SLC6A14, SLC6A12extracellular space, cytosolOne of 4 routes

1. transport of phenylalanine and tyrosine (cytosol to extracellular)
2. thyroid peroxidase (iodine)

Catalysed by SLC7A5, TPOextracellular space, cytosolOne of 2 routes

1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
2. L-dopa + H(+) = dopamine + CO2

Catalysed by SLC7A8, DDCinner side of the membrane, outer side of the membrane

1. transport of alanine and phenylalanine (cytosol to extracellular)
2. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

Catalysed by SLC7A5, SLC1A4extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

1. transport of glycine and phenylalanine (cytosol to extracellular)
2. Hippurate (Benzoylglycinate) Formation

Catalysed by SLC7A5extracellular space, cytosol, mitochondrial matrixOne of 2 routes

1. transport of cysteine and phenylalanine (cytosol to extracellular)
2. L-Cysteine:oxygen oxidoreductase

Catalysed by SLC7A5, CDO1extracellular space, cytosolOne of 6 routes

1. transport of alanine and phenylalanine (cytosol to extracellular)
2. gamma-glutamyltransferase (alanine)

Catalysed by SLC7A5, GGTLC3, GGT1, GGT5 and 3 moreextracellular space, cytosolOne of 2 routes

1. transport of arginine and phenylalanine (cytosol to extracellular)
2. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

Catalysed by SLC7A6, NOS3, NOS1, NOS2extracellular space, cytosol

1. transport of alanine and phenylalanine (cytosol to extracellular)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by SLC7A5, MOCOSextracellular space, cytosol

1. transport of glycine and phenylalanine (cytosol to extracellular)
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

Catalysed by SLC7A5, AGXT2extracellular space, cytosolOne of 3 routes

1. Phenylalanine Transaminase, Mitochondrial
2. Formation of Phenyl-Lactate

Catalysed by GOT2, TATmitochondrial matrix, cytosol

1. transport of cysteine and phenylalanine (cytosol to extracellular)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by SLC7A5, MOCOSextracellular space, cytosol

1. transport of glycine and phenylalanine (cytosol to extracellular)
2. Glycodeoxycholate amidohydrolase

Catalysed by SLC7A5extracellular space, cytosolOne of 2 routes

1. transport of glycine and phenylalanine (cytosol to extracellular)
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

Catalysed by SLC7A5, GLYATL2extracellular space, cytosol

1. transport of glycine and phenylalanine (cytosol to extracellular)
2. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

Catalysed by SLC7A5, BAATextracellular space, cytosol

1. transport of glycine and phenylalanine (cytosol to extracellular)
2. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

Catalysed by SLC7A5, BAATextracellular space, cytosol

1. transport of glycine and phenylalanine (cytosol to extracellular)
2. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

Catalysed by SLC7A5, BAATextracellular space, cytosol

1. transport of glutamine and phenylalanine (cytosol to extracellular)
2. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

Catalysed by SLC7A5, GLYATL1B, GLYATL1extracellular space, cytosol

1. transport of phenylalanine and tyrosine (cytosol to extracellular)
2. L-tyrosine:2-oxoglutarate aminotransferase
3. (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + NADH + H(+)

Catalysed by SLC7A5, GOT2, GOT1, TAT and 1 moreextracellular space, cytosol

1. transport of alanine and phenylalanine (cytosol to extracellular)
2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
3. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)