leukotriene C4

Three steps

• 5-hydroxy-L-tryptophanReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DDCextracellular space, cytosolOne of 2 routes

• prostaglandin F1Reach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin E1 (cytosol to extracellular)
  3. prostaglandin E1 + NADPH + H(+) = prostaglandin F1 + NADP(+)

  Catalysed by SLCO1B1, SLCO2A1, DHRS1extracellular space, cytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and leucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A5, BCAT2cytosol, extracellular space, mitochondrial matrixOne of 5 routes

• CHEBI:17927Reach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by BAATcytosol, peroxisomeOne of 2 routes

• butanoateReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)

  Catalysed by SLCO1B1, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• 3-phenylpyruvateReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by SLC7A5, GOT2, TATcytosol, extracellular space, mitochondrial matrixOne of 6 routes

• fumaric acidReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. transport of fumarate and sulfite (cytosol to mitochondria)

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 moremitochondrial matrix, cytosolOne of 2 routes

• 5-hydroxyisourateReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. urate:oxygen oxidoreductase

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 1 moreinner side of the membrane, outer side of the membrane, cytosol

• (R)-3,4-dihydroxymandelaldehydeReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. (R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, MAOA and 1 moreextracellular space, cytosol

• CHEBI:18095Reach from here →
  1. leukotriene C4 hydrolysis
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, CLTRN, SLC6A20cytosol, extracellular spaceOne of 5 routes

• CHEBI:18183Reach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. gamma-glutamyltransferase (alanine)
  3. gamma-glutamylcyclotransferase ((5-L-glutamyl)-L-amino acid)

  Catalysed by SLCO1B1, GGT1, GGT5, GGTLC2 and 5 moreextracellular space, cytosol

• N-carbamoyl-beta-alanineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of chloride and glycine (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by SLC6A9, SLC6A14cytosol, extracellular spaceOne of 2 routes

• N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. leukotriene C4 hydrolysis
  2. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)
  3. 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase

  Catalysed by GARTcytosol

• 2-phenylethylamineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by SLC7A5, DDCcytosol, extracellular space

• hydrogen cyanideReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 3 moremitochondrial matrixOne of 2 routes

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by SLC7A5, PFAScytosol, extracellular space

• gamma-L-glutamyl-(2S)-2-aminobutanoateReach from here →
  1. leukotriene C4 hydrolysis
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. (2S)-2-aminobutanoate + L-glutamate + ATP = gamma-L-glutamyl-(2S)-2-aminobutanoate + ADP + phosphate + H(+)

  Catalysed by AGXT2, GCLCcytosol

• (R)-normetanephrineReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:catechol O-methyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, COMT and 1 moreextracellular space, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and methionine (cytosol to extracellular)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by SLC7A5, SLC7A8cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of alanine and glycine (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by SLC3A2, SLC7A5, SLC7A10cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• (6R)-10-formyltetrahydrofolateReach from here →
  1. leukotriene C4 hydrolysis
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
  3. (6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate

  Catalysed by SHMT1, SHMT2, MTHFD1, MTHFD1Lcytosol

• glycodeoxycholate 3-sulfateReach from here →
  1. leukotriene C4 hydrolysis
  2. Glycodeoxycholate amidohydrolase
  3. glycodeoxycholate + 3'-phosphoadenylyl sulfate = glycodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SULT2A1cytosol

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. leukotriene C4 hydrolysis
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by AADAT, AGXT2cytosolOne of 7 routes

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. leukotriene C4 hydrolysis
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by AADAT, AGXT2cytosolOne of 3 routes

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. leukotriene C4 hydrolysis
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

  Catalysed by AADAT, AGXT2cytosolOne of 3 routes

• (6R)-5,10-methylenetetrahydrofolic acidReach from here →
  1. leukotriene C4 hydrolysis
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SHMT1cytosolOne of 7 routes

• S-disulfanyl-L-cysteineReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by SLCO1B1, CARS2extracellular space, cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by BAAT, HADHA, ACAA2, HADHBcytosol, peroxisome, mitochondrial matrixOne of 2 routes

• O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronate + UDP

  Catalysed by SLCO1B1, UGT1A9, UGT2B7, UGT1A6 and 3 moreextracellular space, cytosol

• 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
  3. 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP + H(+)

  Catalysed by SLCO1B1, SLCO2A1, UGT2B7, UGT1A1 and 1 moreextracellular space, cytosol

• 15-O-(beta-D-glucuronosyl)-prostaglandin B1Reach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin B1 (cytosol to extracellular)
  3. prostaglandin B1 + UDP-alpha-D-glucuronate = 15-O-(beta-D-glucuronosyl)-prostaglandin B1 + UDP + H(+)

  Catalysed by SLCO1B1, SLCO2A1, UGT1A9, UGT2B7 and 2 moreextracellular space, cytosol

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, peroxisomeOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, peroxisomeOne of 8 routes

• serotonin O-sulfateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. serotonin + 3'-phosphoadenylyl sulfate = serotonin O-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 1 moreextracellular space, cytosol

• (R)-noradrenaline 4'-O-sulfateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. sulfotransferase (noradrenaline)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3extracellular space, cytosolOne of 2 routes

• L-homocysteine thiolactoneReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. Formation of Homocystine
  3. arylesterase (homocysteine-thiolactone)

  Catalysed by SLCO1B1, PON1, PON2, PON3extracellular space, cytosol

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by BAAT, HADHA, ACADVL, HADHBcytosol, peroxisome, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by BAAT, HADHA, ACADVL, HADHBcytosol, peroxisome, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by BAAT, ECHS1, ACAA2, HADHcytosol, peroxisome, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by BAAT, ECHS1, ACAA2, HADHcytosol, peroxisome, mitochondrial matrixOne of 2 routes

• ursodeoxycholate 3-sulfateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. ursodeoxycholate + 3'-phosphoadenylyl sulfate = ursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• tauroursodeoxycholate 3-sulfateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and tauroursodeoxycholate (cytosol to extracellular)
  3. tauroursodeoxycholate + 3'-phosphoadenylyl sulfate = tauroursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• glycoursodeoxycholate 3-sulfateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of glycoursodeoxycholate and GSH (cytosol to extracellular)
  3. glycoursodeoxycholate + 3'-phosphoadenylyl sulfate = glycoursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• chenodeoxycholate 3-sulfateReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)
  3. chenodeoxycholate + 3'-phosphoadenylyl sulfate = chenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• glycochenodeoxycholate 3-sulfateReach from here →
  1. leukotriene C4 hydrolysis
  2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)
  3. glycochenodeoxycholate + 3'-phosphoadenylyl sulfate = glycochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by BAAT, SULT2A1cytosol

• deoxycholateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (cholate)
  3. cytochrome P450 (cholate)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, CYP7A1extracellular space, cytosolOne of 5 routes

• dimethylarsinous acidReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)
  3. arsenic triglutathione + 2 [thioredoxin]-dithiol + 2 S-adenosyl-L-methionine + H2O = dimethylarsinous acid + 2 [thioredoxin]-disulfide + 3 glutathione + 2 S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 1 more

• hypochlorous acidReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of chloride and glycine (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLC6A9, SLC6A14, LPOcytosol, extracellular spaceOne of 4 routes

• potassium atomReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. transport of serotonin (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLC6A4extracellular space, cytosolOne of 3 routes

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamineReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. fatty acylamide amidohydrolase

  Catalysed by SLCO1B1, FAAHextracellular space, cytosol