Catalyst

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Search ?

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

Reach

a 2-acyl-sn-glycero-3-phosphocholine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

363 compounds within 3 steps: 7 in 1, 46 in 2, 310 in 3

Does it reach a compound?

Two steps

2-(acylamino)ethyl fatty acidReach from here →
1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
2. an N-acylethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 2-(acylamino)ethyl fatty acid + a 2-acyl-sn-glycero-3-phosphocholine
Catalysed by LPGAT1, PLA2G15One of 2 routes
1-O-acyl-N-(acetyl)-sphing-4-enineReach from here →
1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
2. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine
Catalysed by LPGAT1, PLA2G15One of 2 routes
1,2-diacyl-sn-glycero-3-phosphoethanolReach from here →
1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
2. ethanol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1,2-diacyl-sn-glycero-3-phosphoethanol + choline
Catalysed by LPGAT1, PLD1

Three steps

(S)-carnitineReach from here →
Catalysed by ENPP2, CHAT, CPT1A, CPT1C and 1 morecytosolOne of 245 routes
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphateReach from here →

Page 2 of 8

Catalysed by ENPP2, CHDH, MOCS1

AReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
choline + A = betaine aldehyde + AH2
A + NADH + H(+) = AH2 + NAD(+)

Catalysed by ENPP2, CHDH, AIFM1, PYROXD1One of 70 routes

an acyl-4'-phosphopantetheineReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by LPGAT1, NUDT19, FITM2, NUDT8

(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
choline + A = betaine aldehyde + AH2
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O

Catalysed by ENPP2, CHDH, PTGS2

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
choline + A = betaine aldehyde + AH2
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O

Catalysed by ENPP2, CHDH, PTGS2

prostaglandin H3Reach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
choline + A = betaine aldehyde + AH2
prostaglandin G3 + AH2 = prostaglandin H3 + A + H2O

Catalysed by ENPP2, CHDH, PTGS2

13-hydroxy-(9Z,11E)-octadecadienoateReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
choline + A = betaine aldehyde + AH2
(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O

Catalysed by ENPP2, CHDH, PTGS2

9-hydroxy-(10E,12Z)-octadecadienoateReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
choline + A = betaine aldehyde + AH2
(9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O

Catalysed by ENPP2, CHDH, PTGS2

2,4-dinitrophenyl-S-glutathioneReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
Acetyl-CoA:choline O-acetyltransferase
transport of acetylcholine (cytosol to extracellular)

Catalysed by ENPP2, CHAT, SLCO1B3cytosol, extracellular spaceOne of 2 routes

(13R)-hydroxy-(9Z,11E)-octadecadienoateReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
choline + A = betaine aldehyde + AH2
(9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O

Catalysed by ENPP2, CHDH, PTGS1, PTGS2

2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
choline + A = betaine aldehyde + AH2
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by ENPP2, CHDH, PTGS2

2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
choline + A = betaine aldehyde + AH2
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by ENPP2, CHDH, PTGS2

2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
choline + A = betaine aldehyde + AH2
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by ENPP2, CHDH, PTGS2

2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamineReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
choline + A = betaine aldehyde + AH2
2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O

Catalysed by ENPP2, CHDH, PTGS2

2-(prostaglandin H2)-sn-glycero-3-phosphocholineReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
choline + A = betaine aldehyde + AH2
2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O

Catalysed by ENPP2, CHDH, PTGS2

1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholineReach from here →

1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine = a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine
2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine

Catalysed by PLAAT1, ASPG, PLAAT2

1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →

1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine = a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine
2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine

Catalysed by PLAAT1, ASPG, PLAAT2

1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamineReach from here →

1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine = a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine
2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)

Catalysed by PLAAT1, ASPG, PLA2G4E

a 3-hydroxyacyl derivative of bacterial toxinReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)
a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = a 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)
a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = a 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)

Catalysed by ASPG, AOAH

sn-glycero-3-phosphoethanolamineReach from here →

1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine = a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine
a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + (24S)-hydroxycholesterol = (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine
1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine

Catalysed by PLAAT1, LCAT, PLA2G4C

a 2-acyl-6-alpha-D-glucosaminyl-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)
a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + a fatty acyl-CoA = a 2-acyl-6-alpha-D-glucosaminyl-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + CoA

Catalysed by ASPG, ACSL3, PIGW

an N-(fatty acyl)-glycineReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)
a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

Catalysed by ASPG, ACSL3, GLYATL2

(7Z)-octadecenoyl-CoAReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
acyl-CoA pool formation and breakdown

Catalysed by LPGAT1cytosolOne of 4 routes

CHEBI:15345Reach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
Acetyl-CoA:choline O-acetyltransferase
Acetoacetate:CoA ligase (AMP-forming)

Catalysed by ENPP2, CHAT, AACScytosolOne of 2 routes

CHEBI:15380Reach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
Acetyl-CoA:choline O-acetyltransferase
5-aminolevulinate synthase (2-amino-3-oxoadipate)

Catalysed by ENPP2, CHAT, ALAS1, CPNE7cytosol, mitochondrial matrixOne of 8 routes

CHEBI:15477Reach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
Acetyl-CoA:choline O-acetyltransferase
glycine N-acyltransferase (2-methylbutyryl-CoA)

Catalysed by ENPP2, CHAT, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

2-methylcrotonoyl-CoAReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
Acetyl-CoA:choline O-acetyltransferase
Production of Tiglylcarnitine

Catalysed by ENPP2, CHAT, CPT1A, CPT1BcytosolOne of 2 routes

isobutyryl-CoAReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
Acetyl-CoA:choline O-acetyltransferase
acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

Catalysed by ENPP2, CHAT, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 3 routes

3-methylbut-2-enoyl-CoAReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
Acetyl-CoA:choline O-acetyltransferase
glycine-N-acyltransferase (3-methylcrotonoylglycine)

Catalysed by ENPP2, CHAT, GLYATcytosol, mitochondrial matrix

isovaleryl-CoAReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
Acetyl-CoA:choline O-acetyltransferase
glycine N-acyltransferase (isovalerylglycine)

Catalysed by ENPP2, CHAT, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrixOne of 3 routes

arachidonoyl-CoAReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
acyl-CoA pool formation and breakdown

Catalysed by LPGAT1cytosolOne of 12 routes

CHEBI:15519Reach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
Acetyl-CoA:choline O-acetyltransferase
propanoyl-CoA C-acyltransferase

Catalysed by ENPP2, CHAT, ACAA1, SCP2 and 1 morecytosol, peroxisomeOne of 2 routes

palmitoyl-CoAReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
acyl-CoA pool formation and breakdown

Catalysed by LPGAT1cytosolOne of 12 routes

oleoyl-CoAReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
acyl-CoA pool formation and breakdown

Catalysed by LPGAT1cytosolOne of 12 routes

phenylacetyl-CoAReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
Acetyl-CoA:choline O-acetyltransferase
Phenylacetate:CoA ligase

Catalysed by ENPP2, CHATcytosolOne of 3 routes

propionyl-CoAReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
Acetyl-CoA:choline O-acetyltransferase
Propanoate:CoA ligase (AMP-forming)

Catalysed by ENPP2, CHAT, ACSS3, ACSS2 and 1 morecytosolOne of 43 routes

L-leucineReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
transport of chloride and choline (cytosol to extracellular)
transport of chloride and leucine (cytosol to extracellular)

Catalysed by ENPP2, SLC5A7, SLC6A14extracellular space, cytosolOne of 2 routes

CHEBI:15650Reach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
Acetyl-CoA:choline O-acetyltransferase
N-acetyl-LTE4 to leukotriene E4 conversion

Catalysed by ENPP2, CHAT, ZDHHC11B, NAA10 and 30 morecytosolOne of 2 routes

CHEBI:15727Reach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
Acetyl-CoA:choline O-acetyltransferase
N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

Catalysed by ENPP2, CHAT, NAA10cytosol

CHEBI:15746Reach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
Acetyl-CoA:choline O-acetyltransferase
diamine N-acetyltransferase (N1-acetylspermine)

Catalysed by ENPP2, CHAT, SAT1, SAT2cytosolOne of 2 routes

1-acylglycerone 3-phosphateReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
Acyl-CoA:glycerone-phosphate O-acyltransferase

Catalysed by LPGAT1, GNPATcytosol

a sterolReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
a sterol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sterol ester + a 1-acyl-sn-glycero-3-phosphocholine

Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G1B and 28 moreOne of 3 routes

CHEBI:15971Reach from here →

a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
transport of chloride and choline (cytosol to extracellular)
transport of chloride and histidine (cytosol to extracellular)

Catalysed by ENPP2, SLC5A7, SLC6A14extracellular space, cytosol

phosphatidylethanolamineReach from here →

a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase

Catalysed by LPGAT1, LPCAT4, LPCAT3, LPCAT2 and 1 morecytosolOne of 2 routes

CHEBI:16108Reach from here →

2 a 2-acyl-sn-glycero-3-phosphocholine = sn-glycerol 3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphocholine
sn-Glycero-3-phosphocholine glycerophosphohydrolase
sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase

Catalysed by ASPG, GPCPD1, GPD2cytosol, mitochondrial matrixOne of 2 routes

1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →

a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

Catalysed by LPGAT1, LPCAT4, LPCAT3, LPCAT2 and 1 morecytosolOne of 2 routes