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Proteins/UNIPROT:P28039
Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides. By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity)..
Function from UniProtKB (P28039), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
11 statements
11 statements · 4 reference databases · Subject: AOAH · Sources: Bgee, gene ontology, Rhea, UniProt
2 reactions
MAM00683c+2waterMAM00774c+2proton+2fatty acid
Catalysed by AOAH
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.77cytosol
Human-GEM MAR09554CC BY 4.0Reference data
a 3-(acyloxy)acyl derivative of bacterial toxin+watera 3-hydroxyacyl derivative of bacterial toxin+a fatty acid+hydron
Catalysed by
1 name
Resolves to: AOAH
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:12032CC BY 4.0Reference data