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Reach

L-dopa

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

295 compounds within 3 steps: 3 in 1, 48 in 2, 244 in 3

Does it reach a compound?

Two steps

CHEBI:742324Reach from here →
1. L-dopa + H(+) = dopamine + CO2
2. S-Adenosyl-L-methionine:catechol O-methyltransferase
Catalysed by DDC, COMT, LRTOMTcytosol

Three steps

beta-carbolineReach from here →
Catalysed by SLC7A8, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosol
(S)-carnitineReach from here →
Catalysed by SLC7A8

Page 2 of 6

, SLC6A14

inner side of the membrane, outer side of the membrane, extracellular space, cytosol

CHEBI:1146900Reach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of glycine and phenylalanine (cytosol to extracellular)
bile acid-CoA: amino acid N-acyltransferase

Catalysed by SLC7A8, SLC7A5, BAATinner side of the membrane, outer side of the membrane, extracellular space, cytosol, peroxisomeOne of 40 routes

N(omega)-methyl-L-arginineReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of glycine and phenylalanine (cytosol to extracellular)
N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

Catalysed by SLC7A8, SLC7A5, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

3-methyl-2-oxobutanoateReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of phenylalanine and valine (cytosol to extracellular)
L-Valine:2-oxoglutarate aminotransferase

Catalysed by SLC7A8, SLC7A5, BCAT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 3 routes

AReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of cysteine and phenylalanine (cytosol to extracellular)
Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by SLC7A8, SLC7A5, MOCOSinner side of the membrane, outer side of the membrane, extracellular space, cytosol

tauroursodeoxycholateReach from here →

L-dopa + H(+) = dopamine + CO2
transport of dopamine (cytosol to extracellular)
transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

glycoursodeoxycholateReach from here →

L-dopa + H(+) = dopamine + CO2
transport of dopamine (cytosol to extracellular)
transport of glycoursodeoxycholate (cytosol to extracellular)

Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 6 routes

(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →

L-dopa + H(+) = dopamine + CO2
transport of dopamine and GSH (cytosol to extracellular)
glutathione transferase (GSH)

Catalysed by DDC, SLCO1A2, SLCO1B3, PTGES and 20 moreextracellular space, cytosolOne of 4 routes

prostaglandin E3Reach from here →

L-dopa + H(+) = dopamine + CO2
transport of dopamine (cytosol to extracellular)
transport of prostaglandin E3 (cytosol to extracellular)

Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

prostaglandin A2Reach from here →

L-dopa + H(+) = dopamine + CO2
transport of dopamine (cytosol to extracellular)
transport of prostaglandin A2 (cytosol to extracellular)

Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

prostaglandin B1Reach from here →

L-dopa + H(+) = dopamine + CO2
transport of dopamine (cytosol to extracellular)
transport of prostaglandin B1 (cytosol to extracellular)

Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

leukotriene F4Reach from here →

L-dopa + H(+) = dopamine + CO2
transport of dopamine (cytosol to extracellular)
transport of leukotriene F4 (cytosol to extracellular)

Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

N-(9Z-octadecenoyl)glycineReach from here →

L-dopa + H(+) = dopamine + CO2
dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O
N-(9Z-octadecenoyl)glycine + 2 L-ascorbate + O2 = N-(9Z-octadecenoyl)-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Catalysed by DDC, DBH, PAMOne of 2 routes

N-(9Z-octadecenoyl)-L-leucineReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of leucine and phenylalanine (cytosol to extracellular)
N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

Catalysed by SLC7A8, SLC7A5, PM20D1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

N-octadecanoylglycineReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of glycine and phenylalanine (cytosol to extracellular)
octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

Catalysed by SLC7A8, SLC7A5, GLYATL2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

N-(9Z-hexadecenoyl)-glycineReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of glycine and phenylalanine (cytosol to extracellular)
(9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

Catalysed by SLC7A8, SLC7A5, GLYATL2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

N-hexadecanoylglycineReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of glycine and phenylalanine (cytosol to extracellular)
hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

Catalysed by SLC7A8, SLC7A5, GLYATL3inner side of the membrane, outer side of the membrane, extracellular space, cytosol

N-dodecanoylglycineReach from here →

L-dopa + H(+) = dopamine + CO2
dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O
N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Catalysed by DDC, DBH, PAMOne of 2 routes

N-(9Z,12Z,15Z)-octadecatrienoylglycineReach from here →

L-dopa + H(+) = dopamine + CO2
dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O
N-(9Z,12Z,15Z)-octadecatrienoylglycine + 2 L-ascorbate + O2 = N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Catalysed by DDC, DBH, PAM

N-decanoylglycineReach from here →

L-dopa + H(+) = dopamine + CO2
dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O
N-decanoylglycine + 2 L-ascorbate + O2 = N-decanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Catalysed by DDC, DBH, PAMOne of 2 routes

N-octanoylglycineReach from here →

L-dopa + H(+) = dopamine + CO2
dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O
N-octanoylglycine + 2 L-ascorbate + O2 = N-octanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Catalysed by DDC, DBH, PAMOne of 2 routes

D-histidineReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of ornithine and phenylalanine (cytosol to extracellular)
D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)

Catalysed by SLC7A8, SLC7A6, SLC25A2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

L-homoarginineReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of arginine and phenylalanine (cytosol to extracellular)
L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)

Catalysed by SLC7A8, SLC7A6, SLC25A29inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

L-homocarnosineReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of histidine and phenylalanine (cytosol to extracellular)
Formation of homocarnosine

Catalysed by SLC7A8, SLC7A6, CARNS1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of glycine and phenylalanine (cytosol to extracellular)
5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

Catalysed by SLC7A8, SLC7A5, GARTinner side of the membrane, outer side of the membrane, extracellular space, cytosol

L-cystine-bis-glycineReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of glycine and phenylalanine (cytosol to extracellular)
L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

Catalysed by SLC7A8, SLC7A5, DPEP1, DPEP2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

glycyldehydrophenylalanineReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of glycine and phenylalanine (cytosol to extracellular)
glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

Catalysed by SLC7A8, SLC7A5, DPEP1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of glutamine and phenylalanine (cytosol to extracellular)
N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

Catalysed by SLC7A8, SLC7A5, PFASinner side of the membrane, outer side of the membrane, extracellular space, cytosol

kinetensin-(1-8)Reach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
Chymase
kinetensin + H2O = kinetensin-(1-8) + L-leucine

Catalysed by SLC7A8, CMA1, ACE2inner side of the membrane, outer side of the membrane, extracellular space

an N-(fatty acyl)-glycineReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of glycine and phenylalanine (cytosol to extracellular)
a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

Catalysed by SLC7A8, SLC7A5, GLYATL2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

N-(9Z,12Z-octadecadienoyl)-glycineReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of glycine and phenylalanine (cytosol to extracellular)
(9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

Catalysed by SLC7A8, SLC7A5, GLYATL2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

acetaldehydeReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of phenylalanine and threonine (cytosol to extracellular)
L-threonine acetaldehyde-lyase (glycine-forming)

Catalysed by SLC7A8, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosol

cholineReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
Transport of L-Phenylalanine by Atb0 Transporter
transport of chloride and choline (cytosol to extracellular)

Catalysed by SLC7A8, SLC6A14, SLC5A7inner side of the membrane, outer side of the membrane, extracellular space, cytosol

acetylcholineReach from here →

L-dopa + H(+) = dopamine + CO2
transport of dopamine (cytosol to extracellular)
transport of acetylcholine (cytosol to extracellular)

Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

pyruvateReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of alanine and phenylalanine (cytosol to extracellular)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

Catalysed by SLC7A8, SLC7A5, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 16 routes

CHEBI:15570Reach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of glycine and phenylalanine (cytosol to extracellular)
transport of D-alanine and glycine (cytosol to extracellular)

Catalysed by SLC7A8, SLC7A5, SLC3A2, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 5 routes

CHEBI:15611Reach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of glycine and phenylalanine (cytosol to extracellular)
S-Adenosyl-L-methionine:glycine N-methyltransferase

Catalysed by SLC7A8, SLC7A5, GNMTinner side of the membrane, outer side of the membrane, extracellular space, cytosol

CHEBI:15650Reach from here →

L-dopa + H(+) = dopamine + CO2
transport of dopamine (cytosol to extracellular)
transport of leukotriene E4 (cytosol to extracellular)

Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

trimethylenediamineReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of lysine and phenylalanine (cytosol to extracellular)
deoxyhypusine synthase (1,3-diaminopropane)

Catalysed by SLC7A8, SLC7A6, DHPSinner side of the membrane, outer side of the membrane, extracellular space, cytosol

CHEBI:15727Reach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of histidine and phenylalanine (cytosol to extracellular)
L-histidine:beta-alanine ligase (ADP-forming)

Catalysed by SLC7A8, SLC7A6, CARNS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

bromideReach from here →

L-dopa + H(+) = dopamine + CO2
transport of dopamine and GSH (cytosol to extracellular)
2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase

Catalysed by DDC, SLCO1A2, SLCO1B3, MGST3 and 16 moreextracellular space, cytosolOne of 2 routes

N-carbamoyl-L-aspartic acidReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
carbamoyl-phosphate:L-aspartate carbamoyltransferase

Catalysed by SLC7A8, SLC7A13, CADinner side of the membrane, outer side of the membrane, cytosol

alpha-D-glucosamine 6-phosphateReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of glutamine and phenylalanine (cytosol to extracellular)
L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

Catalysed by SLC7A8, SLC7A5, GFPT2, GFPT1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

thioredoxin dithiolReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)
glycyl-tRNA(gly) phosphorylation

Catalysed by SLC7A8, FARSB, FARSAinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

sulfateReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
Transport of L-Phenylalanine by Atb0 Transporter
transport of chloride and sulfate (cytosol to extracellular)

Catalysed by SLC7A8, SLC6A14, SLC26A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

ureaReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of arginine and phenylalanine (cytosol to extracellular)
L-Arginine amidinohydrolase

Catalysed by SLC7A8, SLC7A6, ARG1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

L-cystineReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of alanine and phenylalanine (cytosol to extracellular)
Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

Catalysed by SLC7A8, SLC7A5, SLC7A9, SLC3A1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 9 routes

(R)-3-aminoisobutyric acidReach from here →

L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
transport of alanine and phenylalanine (cytosol to extracellular)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

Catalysed by SLC7A8, SLC7A5, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix