2-oxoadipate

Three steps

• L-sepiapterinReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)

  Catalysed by AADAT, SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by AADAT, AGXT2

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by AADAT, SHMT1cytosolOne of 2 routes

• CHEBI:240943Reach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by AADAT, GLYAT, GLYATL2, GLYATL1mitochondrial matrix

• phenylacetylglycineReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by AADAT, GLYATcytosolOne of 3 routes

• CHEBI:28666Reach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. LTD4 hydrolysis

  Catalysed by AADATcytosol

• Gly-tRNA(Gly)Reach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by AADAT, GARS1cytosol

• chlorine(.)Reach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. transport of chloride and glycine (cytosol to extracellular)

  Catalysed by AADAT, SLC6A9, SLC6A14extracellular space, cytosolOne of 3 routes

• glycocholateReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)

  Catalysed by AADAT, SLC22A6, SLC22A24inner side of the membrane, outer side of the membraneOne of 5 routes

• adipic acidReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. hexanedioate + glutaryl-CoA = hexanedioyl-CoA + glutarate

  Catalysed by AADAT, SLC22A6, SUGCTinner side of the membrane, outer side of the membrane

• (indol-3-yl)acetateReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  3. (indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-yl)acetate(in) + a dicarboxylate(out)

  Catalysed by AADAT, SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-aminolevulinateReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by AADAT, ALAS1, ALAS2

• glycochenodeoxycholateReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by AADAT, BAAT

• taurocholateReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. taurocholate(out) + glutarate(in) = taurocholate(in) + glutarate(out)

  Catalysed by AADAT, SLC22A6, SLC22A24, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• glycochenodeoxycholic acidReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by AADAT, BAATperoxisomeOne of 3 routes

• glyoxylateReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by AADATOne of 11 routes

• glycolithocholic acidReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by AADAT, BAATcytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by AADAT, GCATmitochondrial matrix

• L-erythro-7,8-dihydrobiopterinReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  3. L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by AADAT, SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• L-ornithineReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. L-Arginine:glycine amidinotransferase

  Catalysed by AADAT, GATMcytosolOne of 5 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by AADAT, GLDC, GCSHmitochondrial matrix

• glutaryl-CoAReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. glutarate + succinyl-CoA = glutaryl-CoA + succinate

  Catalysed by AADAT, SLC22A6, SUGCTinner side of the membrane, outer side of the membraneOne of 4 routes

• prostaglandin F2alphaReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. prostaglandin F2alpha(out) + glutarate(in) = prostaglandin F2alpha(in) + glutarate(out)

  Catalysed by AADAT, SLC22A6, SLC22A8inner side of the membrane, outer side of the membraneOne of 4 routes

• sarcosineReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by AADAT, PIPOXOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by AADAT, SHMT1, SHMT2

• an N-acylglycineReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by AADAT, GLYATL3, GLYAT, GLYATL2

• guanidinoacetateReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. L-Arginine:glycine amidinotransferase

  Catalysed by AADAT, GATMcytosolOne of 2 routes

• 3',5'-cyclic GMPReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  3. 3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)

  Catalysed by AADAT, SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• L-methionineReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. transport of glycine and methionine (cytosol to extracellular)

  Catalysed by AADAT, SLC7A5extracellular space, cytosolOne of 5 routes

• dehydroepiandrosterone 3-sulfateReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)

  Catalysed by AADAT, SLC22A6, SLC22A24, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• L-tryptophanReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. transport of glycine and tryptophan (cytosol to extracellular)

  Catalysed by AADAT, SLC7A5extracellular space, cytosolOne of 5 routes

• glutathioneReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by AADAT, GSS

• L-alanineReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. transport of alanine and glycine (cytosol to extracellular)

  Catalysed by AADAT, SLC3A2, SLC7A5, SLC7A10extracellular space, cytosolOne of 6 routes

• leukotriene C4Reach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. leukotriene C4 hydrolysis

  Catalysed by AADATcytosol

• L-asparagineReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. transport of asparagine and glycine (cytosol to extracellular)

  Catalysed by AADATextracellular space, cytosolOne of 4 routes

• L-phenylalanineReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. transport of glycine and phenylalanine (cytosol to extracellular)

  Catalysed by AADAT, SLC7A5extracellular space, cytosolOne of 7 routes

• 3',5'-cyclic AMPReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  3. 3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)

  Catalysed by AADAT, SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• L-tyrosineReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by AADAT

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by AADAT, AGXT2

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by AADAT, GLYATL2One of 2 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by AADAT, SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• estrone 3-sulfateReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)

  Catalysed by AADAT, SLC22A6, SLC22A24, SLC22A8 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin E2Reach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. prostaglandin E2(out) + glutarate(in) = prostaglandin E2(in) + glutarate(out)

  Catalysed by AADAT, SLC22A6, SLC22A8inner side of the membrane, outer side of the membraneOne of 4 routes

• N-benzoylglycineReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  3. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)

  Catalysed by AADAT, SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 4 routes

• (2S)-2-aminobutanoateReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by AADAT, AGXT2

• 17beta-estradiol 17-O-(beta-D-glucuronate)Reach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by AADAT, SLC22A6, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• glycodeoxycholateReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. Glycodeoxycholate amidohydrolase

  Catalysed by AADATcytosolOne of 2 routes

• N-tetradecanoylglycineReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by AADAT, GLYATL2

• N-eicosanoylglycinateReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by AADAT, BAAT

• N-docosanoylglycineReach from here →
  1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by AADAT, BAAT