octadecanoyl-CoA

Two steps

• (5Z)-dodecenoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 6 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 9 routes

• 3-oxo-(9Z)-eicosenoyl-CoAReach from here →
  1. stearoyl-CoA 9-desaturase (stearoyl-CoA)
  2. very-long-chain 3-oxoacyl-CoA synthase ((7Z)-octadecenoyl-CoA)

  Catalysed by SCD, SCD5, ELOVL7, ELOVL1 and 5 morecytosol

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:27540Reach from here →
  1. Stearoyl-CoA hydrolase
  2. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 7 morecytosolOne of 6 routes

• CHEBI:28701Reach from here →
  1. Stearoyl-CoA hydrolase
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, peroxisomeOne of 7 routes

• (9Z)-octadecenoateReach from here →
  1. stearoyl-CoA desaturase (N-C18:0CoA -> N-C18:1CoA)
  2. Oleoyl-CoA hydrolase

  Catalysed by SCD, ACOT7, BAAT, THEM4 and 2 morecytosolOne of 3 routes

• an N-acylsphinganineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. sphingosine N-acyltransferase (sphinganine)

  Catalysed by CERS1, CERS6, CERS3, CERS5 and 2 morecytosol

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

  Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G4A

• 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholineReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by SCD, SCD5, LPCAT4

• fatty acidReach from here →
  1. Stearoyl-CoA hydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 8 routes

• cholesteryl hexadecanoateReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 2 moreperoxisome, endoplasmic reticulum

• a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1cytosol

• cholesteryl (9Z-octadecenoate)Reach from here →
  1. stearoyl-CoA desaturase (N-C18:0CoA -> N-C18:1CoA)
  2. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by SCD, SOAT2, SOAT1cytosol, endoplasmic reticulumOne of 2 routes

• a 1,3-diacylglycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA

  Catalysed by MOGAT2, MOGAT1cytosol

• a 1,2-diacylglycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA

  Catalysed by MOGAT2, MOGAT3, LPGAT1, TMEM68 and 1 morecytosolOne of 2 routes

• taurineReach from here →
  1. Stearoyl-CoA hydrolase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 2 routes

• 1,2-di-(9Z-octadecenoyl)-glycerolReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SCD, SCD5, DGAT1, MOGAT2 and 4 moreOne of 2 routes

• 1,2-di-(9Z-octadecenoyl)-sn-glycerolReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA

  Catalysed by SCD, SCD5, DGAT1, MOGAT3 and 1 more

• 1,2,3-tri-(9Z-octadecenoyl)-glycerolReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1,2-di-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SCD, SCD5, DGAT1, MOGAT2 and 6 moreOne of 3 routes

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by LPCAT4, LPCAT3, MBOAT1cytosol

• glycineReach from here →
  1. Stearoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. (S)-methylmalonyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. (2E)-dodecenoyl-CoA formation

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 8 routes

• butanoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. Butanoate:CoA ligase (AMP-forming)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 7 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 10 routes

• glutaryl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. Production of Glutaryl Carnitine

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 13 routes

• itaconyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. Itaconate:CoA ligase (GDP-forming)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. stearoyl-CoA desaturase (N-C18:0CoA -> N-C18:1CoA)
  2. fatty acyl-CoA desaturase (N-C18:1CoA -> N-C18:2CoA)

  Catalysed by SCD, FADS2cytosolOne of 18 routes

• tetradecanoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 14 routes

• octanoyl-CoAReach from here →
  1. stearoyl-CoA desaturase (N-C18:0CoA -> N-C18:1CoA)
  2. Beta Oxidation Fatty Acid

  Catalysed by SCD, ACADM, ACADScytosol, mitochondrial matrixOne of 24 routes

• phytanoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. phytanate-CoA ligase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 5 routes

• 1-hexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 4 moreperoxisome, cytosol

• a 1-acylglycerone 3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA

  Catalysed by GNPATcytosol

• (R)-2-hydroxyoctadecanoateReach from here →
  1. Stearoyl-CoA hydrolase
  2. octadecanoate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol

• ethanolamineReach from here →
  1. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
  2. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine

  Catalysed by LPGAT1, PTDSS2

• a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPGAT1cytosolOne of 2 routes

• an N-acylglycineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by GLYATL3, GLYAT, GLYATL2cytosol

• sphing-4-enineReach from here →
  1. Stearoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, Golgi apparatusOne of 3 routes

• sphinganineReach from here →
  1. sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)
  2. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate

  Catalysed by CERS1, CERS6, CERS3, CERS5 and 3 more

• spermidineReach from here →
  1. Stearoyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosolOne of 3 routes