glutaryl-CoA

Two steps

• CHEBI:28701Reach from here →
  1. Production of Glutaryl Carnitine
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, ACAA1 and 2 morecytosol, peroxisomeOne of 7 routes

• glycocholateReach from here →
  1. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  2. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)

  Catalysed by ACOT8, ACOT4, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• adipic acidReach from here →
  1. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  2. hexanedioate + glutaryl-CoA = hexanedioyl-CoA + glutarate

  Catalysed by ACOT8, ACOT4, SUGCTOne of 4 routes

• 5-aminolevulinateReach from here →
  1. glutarate + succinyl-CoA = glutaryl-CoA + succinate
  2. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by SUGCT, ALAS1, ALAS2

• taurocholateReach from here →
  1. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  2. taurocholate(out) + glutarate(in) = taurocholate(in) + glutarate(out)

  Catalysed by ACOT8, ACOT4, SLC22A24, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• (R)-mevalonateReach from here →
  1. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate
  2. (R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)

  Catalysed by SUGCT, HMGCR

• CHEBI:36882Reach from here →
  1. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
  2. (3S)-citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)

  Catalysed by SUGCT, AUHmitochondrial matrix

• taurineReach from here →
  1. Production of Glutaryl Carnitine
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by CPT1A, CPT1C, CPT1B, BAATcytosolOne of 2 routes

• acetoacetyl-CoAReach from here →
  1. glutarate + succinyl-CoA = glutaryl-CoA + succinate
  2. acetoacetate + succinyl-CoA = acetoacetyl-CoA + succinate

  Catalysed by SUGCT, OXCT1

• glycineReach from here →
  1. Production of Glutaryl Carnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 2 morecytosol, mitochondrial matrixOne of 10 routes

• (3S)-3-hydroxybutanoyl-CoAReach from here →
  1. glutaryl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase (decarboxylating)
  2. (S)-3-hydroxybutanoyl-CoA hydro-lyase

  Catalysed by GCDH, ECHS1mitochondrial matrixOne of 2 routes

• (R)-methylmalonyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by CPT1A, CPT1C, CPT1B, ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. (S)-methylmalonyl-CoA hydrolase

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by CPT1A, CPT1C, CPT1B, ACP2cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. (2E)-dodecenoyl-CoA formation

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by CPT1A, CPT1C, CPT1B, ACAA1 and 1 morecytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. Butanoate:CoA ligase (AMP-forming)

  Catalysed by CPT1A, CPT1C, CPT1B, ACSM4 and 5 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 9 routes

• eicosanoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 12 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, CROTcytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. phytanate-CoA ligase

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 6 morecytosolOne of 15 routes

• prostaglandin F2alphaReach from here →
  1. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  2. prostaglandin F2alpha(out) + glutarate(in) = prostaglandin F2alpha(in) + glutarate(out)

  Catalysed by ACOT8, ACOT4, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• sphing-4-enineReach from here →
  1. Production of Glutaryl Carnitine
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 3 morecytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. Production of Glutaryl Carnitine
  2. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by CPT1A, CPT1C, CPT1B, SAT1 and 1 morecytosolOne of 3 routes

• L-methionineReach from here →
  1. Production of Glutaryl Carnitine
  2. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by CPT1A, CPT1C, CPT1B, NAGScytosol, mitochondrial matrix

• dehydroepiandrosterone 3-sulfateReach from here →
  1. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  2. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)

  Catalysed by ACOT8, ACOT4, SLC22A24, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• L-alanineReach from here →
  1. Production of Glutaryl Carnitine
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. Production of Glutaryl Carnitine
  2. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by CPT1A, CPT1C, CPT1B, NAGScytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. Production of Glutaryl Carnitine
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by CPT1A, CPT1C, CPT1B, NAGScytosol, mitochondrial matrix

• an acyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 3 morecytosol, Golgi apparatusOne of 2 routes

• kynurenateReach from here →
  1. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

  Catalysed by ACOT8, ACOT4, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by CPT1A, CPT1C, CPT1B, HADHA and 2 morecytosol, mitochondrial matrixOne of 3 routes

• (3S)-citramalyl-CoAReach from here →
  1. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
  2. (3S)-citramalyl-CoA = itaconyl-CoA + H2O

  Catalysed by SUGCT, AUH

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 1 morecytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 1 morecytosolOne of 4 routes

• estrone 3-sulfateReach from here →
  1. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  2. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)

  Catalysed by ACOT8, ACOT4, SLC22A24, SLC22A8 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin E2Reach from here →
  1. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  2. prostaglandin E2(out) + glutarate(in) = prostaglandin E2(in) + glutarate(out)

  Catalysed by ACOT8, ACOT4, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• decanoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACSM4 and 5 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. Carnitine O-Palmitoyltransferase

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 11 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol

• CHEBI:63544Reach from here →
  1. Production of Glutaryl Carnitine
  2. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 9 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. Production of Glutaryl Carnitine
  2. Carnitine O-Palmitoyltransferase

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 3 routes