(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

470 compounds within 3 steps: 36 in 1, 92 in 2, 342 in 3

Three steps

(S)-lactateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. prostaglandin-endoperoxide synthase (arachidonate)
3. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 4 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
formaldehydeReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
3. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 5 moreOne of 3 routes
CHEBI:16857Reach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. transport of glycine and threonine (cytosol to extracellular)
Catalysed by GLYATL2, FAAH, PM20D1, SLC3A2 and 2 moreextracellular space, cytosolOne of 4 routes
sn-glycerol 3-phosphocholineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)
Catalysed by LPCAT3, MBOAT7, PLA2G15, PLA2G6 and 15 moreOne of 16 routes
glyoxylic acidReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. glycine:oxygen oxidoreductase (deaminating)
Catalysed by GLYATL2, FAAH, PM20D1, DAOperoxisome
bilirubin IXalphaReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. transport of arachidonate (cytosol to extracellular)
3. transport of bilirubin (cytosol to extracellular)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 4 moreextracellular space, cytosolOne of 4 routes
a cholesterol esterReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. Phosphatidylcholine:sterol O-acyltransferase
Catalysed by SOAT2, SOAT1, CEL, LIPA and 1 morelysosome, cytosolOne of 2 routes
octadecanalReach from here →
1. 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoate + H(+)
3. octadecanal + NAD(+) + H2O = octadecanoate + NADH + 2 H(+)
Catalysed by MBOAT7, DDHD1, ALDH3A2
taurolithocholateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. transport of arachidonate (cytosol to extracellular)
3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 4 moreextracellular space, cytosolOne of 4 routes
L-isoleucineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. transport of glycine and isoleucine (cytosol to extracellular)
Catalysed by GLYATL2, FAAH, PM20D1, SLC7A5extracellular space, cytosolOne of 4 routes
CHEBI:17203Reach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. transport of glycine and proline (cytosol to extracellular)
Catalysed by GLYATL2, FAAH, PM20D1, SLC7A5 and 1 moreextracellular space, cytosolOne of 2 routes
CHEBI:17208Reach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. transport of arachidonate and GSH (cytosol to extracellular)
3. glutathione:dehydroascorbate oxidoreductase
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 1 moreextracellular space, cytosol
homocysteineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. transport of arachidonate and GSH (cytosol to extracellular)
3. Formation of Homocystine
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 1 moreextracellular space, cytosol
N-octadecanoyl-heptadecasphing-4-enineReach from here →
1. 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
3. heptadecasphing-4-enine + octadecanoyl-CoA = N-octadecanoyl-heptadecasphing-4-enine + CoA + H(+)
Catalysed by LPCAT3, LPGAT1, CERS1
all-trans-retinolReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 4 more
linoleic acidReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 1 morecytosol, extracellular spaceOne of 14 routes
a monoacylglycerolReach from here →
1. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
2. a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)
3. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
Catalysed by MBOAT7, AGPAT3, DDHD1, LIPE
O-hexadecanoyl-(R)-carnitineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. Utilized Transport
3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 3 moreendoplasmic reticulum, cytosol, peroxisomeOne of 10 routes
AH2Reach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
3. A + NADH + H(+) = AH2 + NAD(+)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 5 moreOne of 19 routes
7alpha-hydroxycholesterolReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. cytochrome P450 (cholesterol)
Catalysed by SOAT2, SOAT1, CEL, LIPA and 1 morelysosome, endoplasmic reticulum
1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. Phosphatidylcholine:sterol O-acyltransferase
Catalysed by SOAT2, SOAT1, CEL, LIPA and 1 morelysosome, cytosolOne of 2 routes
5-aminolevulinic acidReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)
Catalysed by GLYATL2, FAAH, PM20D1, ALAS1 and 2 moremitochondrial matrix
L-cysteineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. transport of arachidonate and GSH (cytosol to extracellular)
3. cystine to cysteine conversion
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 1 moreextracellular space, cytosolOne of 6 routes
hexadecanalReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
3. hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O
Catalysed by LPCAT3, MBOAT7, PLA2G4B, PLAAT3 and 7 more
all-trans-retinyl hexadecanoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
3. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
Catalysed by LPCAT3, MBOAT7, PLA2G4B, PLAAT3 and 5 more
desmosterolReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. 3-hydroxyacyl-CoA dehydrogenase (desmosterol)
Catalysed by SOAT2, SOAT1, CEL, LIPAlysosome, nucleus
glycerolReach from here →
1. 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
3. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by LPCAT3, PLA2G4A, ABHD16A, ABHD12 and 2 moreOne of 2 routes
CHEBI:17895Reach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. transport of glycine and tyrosine (cytosol to extracellular)
Catalysed by GLYATL2, FAAH, PM20D1, SLC7A5extracellular space, cytosolOne of 4 routes
4-methylpentanalReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. cytochrome P450 (cholesterol)
Catalysed by SOAT2, SOAT1, CEL, LIPA and 1 morelysosome, mitochondrial matrix
CHEBI:18019Reach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. transport of glycine and lysine (cytosol to extracellular)
Catalysed by GLYATL2, FAAH, PM20D1, SLC7A6extracellular space, cytosolOne of 2 routes
L-glutamineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. transport of glutamine and glycine (cytosol to extracellular)
Catalysed by GLYATL2, FAAH, PM20D1, SLC7A5extracellular space, cytosolOne of 4 routes
O-octanoyl-(R)-carnitineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. Utilized Transport
3. solute carrier (L-carnitine)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 2 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 7 routes
dodecanoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 1 morecytosol, extracellular spaceOne of 12 routes
N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)
Catalysed by GLYATL2, FAAH, PM20D1, GARTcytosol
1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
1. 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
3. a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by LPCAT3, LPGAT1
ophthalmateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)
Catalysed by GLYATL2, FAAH, PM20D1, GSS
N(omega),N('omega)-dimethyl-L-arginineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
Catalysed by GLYATL2, FAAH, PM20D1, AGXT2
1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-3-(9Z-octadecenoyl)-glycerolReach from here →
1. 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
3. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-3-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by LPCAT3, PLA2G4A, MOGAT2
5,6,7,8-tetrahydrofolic acidReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
Catalysed by GLYATL2, FAAH, PM20D1, SHMT1cytosolOne of 2 routes
20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. arachidonic acid:oxygen 1-oxidoreductase
3. 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP + H(+)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 31 morecytosol
S-hexadecanoyl-N-acetylcysteamineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
3. S-hexadecanoyl-N-acetylcysteamine + H2O = N-acetylcysteamine + hexadecanoate + H(+)
Catalysed by LPCAT3, MBOAT7, PLA2G4B, PLAAT3 and 6 more
S-hexadecanoyl-N-acetylcysteine methyl esterReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
3. S-hexadecanoyl-N-acetylcysteine methyl ester + H2O = N-acetylcysteine methyl ester + hexadecanoate + H(+)
Catalysed by LPCAT3, MBOAT7, PLA2G4B, PLAAT3 and 5 more
docosanoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 1 morecytosol, extracellular spaceOne of 12 routes
CHEBI:240943Reach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. glycine N-acyltransferase (2-methylbutyryl-CoA)
Catalysed by GLYATL2, FAAH, PM20D1, GLYAT and 1 moremitochondrial matrix
alpha-linolenic acidReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 1 morecytosol, extracellular spaceOne of 13 routes
phenylacetylglycineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. phenylacetyl-CoA:glycine N-phenylacetyltransferase
Catalysed by GLYATL2, FAAH, PM20D1, GLYATcytosolOne of 3 routes
elaidic acidReach from here →
1. 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
3. stearoyl-CoA 9-desaturase (stearoyl-CoA)
Catalysed by LPCAT3, LPGAT1, SCD, SCD5cytosolOne of 13 routes
all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 1 morecytosol, extracellular spaceOne of 12 routes
5(S)-HETEReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. Arachidonate:oxygen 5-oxidoreductase
3. Glutathione: 5-HPETE oxidoreductase
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 11 morecytosolOne of 4 routes
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Catalysed by LPCAT3, MBOAT7, PLA2G15, TAFAZZIN