K(+)

Three steps

• citric acidReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• butyric acidReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by SLC1A1, CTH, SLC16A4, SLC16A5 and 4 moreinner side of the membrane, outer side of the membrane, cytosol, extracellular spaceOne of 2 routes

• maleateReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• malonic acidReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. transport of malonate and sulfate (cytosol to mitochondria)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• 3-hydroxypyruvic acidReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. L-Serine:pyruvate aminotransferase

  Catalysed by SLC1A1, CTH, AGXTinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• (S)-dihydroorotateReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. carbamoyl-phosphate:L-aspartate carbamoyltransferase
  3. (S)-dihydroorotate amidohydrolase

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix

• (2R,3R)-tartrateReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. serotonin(out) + K(+)(in) + Na(+)(out) + H(+)(in) = serotonin(in) + K(+)(out) + Na(+)(in) + H(+)(out)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of arachidonate (cytosol to extracellular)

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• L-lysineReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  3. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membraneOne of 7 routes

• D-lysineReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by SLC1A1, SLC7A6, SLC25A2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• putrescineReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. transport of arginine and cysteine (cytosol to extracellular)
  3. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by SLC1A1, SLC7A6, SLC3A2, SLC7A7inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• D-arginineReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by SLC1A1, SLC7A6, SLC25A2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 3-oxopropanoateReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. L-aspartate 1-carboxy-lyase (beta-alanine-forming)
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• thiosulfateReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 5 moreinner side of the membrane, outer side of the membraneOne of 6 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membrane, cytosol

• tetra-mu3-sulfido-tetrairon(2+)Reach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. De novo synthesis of 2Fe2S
  3. Synthesis of 4Fe4S from 2Fe2S

  Catalysed by SLC1A1, NDUFAB1, FDXR, FXN and 10 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. transport of cysteine and isoleucine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by SLC1A1, SLC7A5, BCAT2, BCAT1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• D-cysteineReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. D-serine(in) + L-glutamine(out) + Na(+)(out) = D-serine(out) + L-glutamine(in) + Na(+)(in)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membraneOne of 11 routes

• 5-aminolevulinateReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by SLC1A1, SLC3A2, SLC7A5, SLC7A8 and 2 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. transport of cysteine and isoleucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC1A1, SLC7A5, BCAT1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• chenodeoxycholateReach from here →
  1. serotonin(out) + K(+)(in) + Na(+)(out) + H(+)(in) = serotonin(in) + K(+)(out) + Na(+)(in) + H(+)(out)
  2. transport of serotonin (cytosol to extracellular)
  3. solute carrier organic anion transporter (chenodiol)

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membraneOne of 6 routes

• glycochenodeoxycholateReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by SLC1A1, SLC3A2, SLC7A5, SLC7A8 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• taurocholateReach from here →
  1. serotonin(out) + K(+)(in) + Na(+)(out) + H(+)(in) = serotonin(in) + K(+)(out) + Na(+)(in) + H(+)(out)
  2. transport of serotonin (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• glycochenodeoxycholic acidReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC1A1, SLC3A2, SLC7A5, SLC7A8 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by SLC1A1, SLC3A2, SLC7A5, SLC7A8 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 11 routes

• glycolithocholic acidReach from here →
  1. serotonin(out) + K(+)(in) + Na(+)(out) + H(+)(in) = serotonin(in) + K(+)(out) + Na(+)(in) + H(+)(out)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of glycolithocholate (cytosol to extracellular)

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 6 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by SLC1A1, SLC3A2, SLC7A5, SLC7A8 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• (R)-lactic acidReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by SLC1A1, CTH, LDHDinner side of the membrane, outer side of the membrane, cytosol

• (S)-lactic acidReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. (S)-Lactate:NAD+ oxidoreductase

  Catalysed by SLC1A1, CTH, LDHB, LDHAL6Binner side of the membrane, outer side of the membrane, cytosol, mitochondrial matrixOne of 5 routes

• 2-iminopropanoateReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by SLC1A1, CTH, RIDAinner side of the membrane, outer side of the membrane, cytosol

• phosphoenolpyruvic acidReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. GTP:oxaloacetate carboxy-lyase (adding GTP

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 3 routes

• N-acetyl-beta-neuraminic acidReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by SLC1A1, CTH, NPLinner side of the membrane, outer side of the membrane, cytosol

• gamma-Glu-AlaReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. gamma-glutamyltransferase (alanine)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 8 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by SLC1A1, SLC3A2, SLC7A5, SLC7A8 and 2 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• taurineReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• 3,3',5-triiodo-L-thyronineReach from here →
  1. serotonin(out) + K(+)(in) + Na(+)(out) + H(+)(in) = serotonin(in) + K(+)(out) + Na(+)(in) + H(+)(out)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• a 3-acylpyruvateReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by SLC1A1, CTH, FAHD1inner side of the membrane, outer side of the membrane, cytosol

• (R)-methylmalonyl-CoAReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 8 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 9 routes