potassium atom

Three steps

• (9Z)-hexadecenoateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC12A2, SLC12A1, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 6 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC12A2, SLC12A1, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 6 routes

• L-lysineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, SLC7A9 and 2 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 5 routes

• putrescineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by SLC12A2, SLC12A1, SLC6A14, SLC3A2 and 1 moreextracellular space, cytosol

• cis-aconitic acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC12A2, SLC12A1, SLC26A6, SLC25A1extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• 3-oxopropanoateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of beta-alanine and chloride (cytosol to extracellular)
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by SLC12A2, SLC12A1, SLC6A6, SLC6A14 and 1 moreextracellular space, cytosol

• thiosulfateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)

  Catalysed by SLC12A2, SLC12A1, SLC26A6, SLC25A14 and 3 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, IL4I1extracellular space, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. De novo synthesis of 2Fe2S

  Catalysed by SLC12A2, SLC12A1, SLC6A14, NDUFAB1 and 6 moreextracellular space, cytosol, mitochondrial matrix

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and isoleucine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by SLC12A2, SLC12A1, SLC6A14, BCAT2 and 1 moreextracellular space, cytosol

• D-cysteineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. D-serine(in) + L-glutamine(out) + Na(+)(out) = D-serine(out) + L-glutamine(in) + Na(+)(in)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, SLC1A5extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 10 routes

• an acylcholineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and choline (cytosol to extracellular)
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by SLC12A2, SLC12A1, SLC5A7, BCHEextracellular space, cytosol

• 5-aminolevulinateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by SLC12A2, SLC12A1, SLC6A9, SLC6A14 and 2 moreextracellular space, cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and isoleucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC12A2, SLC12A1, SLC6A14, BCAT1extracellular space, cytosolOne of 2 routes

• chenodeoxycholateReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. solute carrier organic anion transporter (chenodiol)

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Tyrosine by Atb0 Transporter
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by SLC12A2, SLC12A1, SLC6A14, GOT2 and 2 moreextracellular space, cytosolOne of 6 routes

• glycochenodeoxycholateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by SLC12A2, SLC12A1, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosol

• taurocholateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. Choloyl-CoA:glycine N-choloyltransferase

  Catalysed by SLC12A2, SLC12A1, SLC6A6, BAATextracellular space, cytosol, peroxisomeOne of 7 routes

• taurodeoxycholateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by SLC12A2, SLC12A1, SLC6A6, BAATextracellular space, cytosolOne of 2 routes

• glycochenodeoxycholic acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC12A2, SLC12A1, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by SLC12A2, SLC12A1, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosolOne of 11 routes

• glycolithocholic acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by SLC12A2, SLC12A1, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosolOne of 6 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by SLC12A2, SLC12A1, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosol, mitochondrial matrix

• (S)-lactic acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of formate and L-lactate (cytosol to extracellular)

  Catalysed by SLC12A2, SLC12A1, SLC26A4, SLC16A4 and 5 moreextracellular space, cytosolOne of 2 routes

• phosphoenolpyruvic acidReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. GTP:oxaloacetate carboxy-lyase (adding GTP

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• L-ornithineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. taurine + L-arginine = taurocyamine + L-ornithine

  Catalysed by SLC12A2, SLC12A1, SLC6A6, GATMextracellular space, cytosolOne of 61 routes

• gamma-Glu-AlaReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, GGT1 and 5 moreextracellular space, cytosolOne of 2 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by SLC12A2, SLC12A1, SLC6A9, SLC6A14 and 2 moreextracellular space, cytosol, mitochondrial matrix

• 3,3',5-triiodo-L-thyronineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)

  Catalysed by SLC12A2, SLC12A1, SLC26A4, DIO1 and 2 moreextracellular space, cytosolOne of 8 routes

• (R)-methylmalonyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreextracellular space, cytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreextracellular space, cytosol, mitochondrial matrix, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosol, mitochondrial matrix, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 7 routes

• butanoyl-CoAReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, SLC33A1 and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 11 routes

• dodecanoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 9 routes

• glutaryl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Production of Glutaryl Carnitine

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 12 routes

• itaconyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 11 routes

• octanoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreextracellular space, cytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. phytanate-CoA ligase

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 9 moreextracellular space, cytosol, mitochondrial matrixOne of 15 routes

• prostaglandin E1Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of prostaglandin E1 (cytosol to extracellular)

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin I2Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of prostaglandin I2 (cytosol to extracellular)

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin F2alphaReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin H2Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of prostaglandin H2 (cytosol to extracellular)

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes