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Reach

hydrogen cyanide

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

266 compounds within 3 steps: 3 in 1, 50 in 2, 213 in 3

Does it reach a compound?

Two steps

ubiquinol-10Reach from here →
1. thiosulfate:cyanide sulfurtranserase
2. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate
Catalysed by MPST, TST, SQORmitochondrial matrix
(4S)-4-hydroxy-2-oxoglutarateReach from here →
1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
2. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by MPST, TST, HOGA1cytosol
2-(1-hydroxyethyl)thiamine diphosphateReach from here →
1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
2. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Catalysed by MPST, TST, PDHA1, PDHB and 1 morecytosol, mitochondrial matrix

Three steps

(S)-3-hydroxybutanoateReach from here →
Catalysed by MPST, TST, ADHFE1cytosol, mitochondrial matrix
CHEBI:1146900Reach from here →
Catalysed by

Page 2 of 6

MPST

, TST

, AGXT2

cytosol, mitochondrial matrix

One of 4 routes

N(omega)-methyl-L-arginineReach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

Catalysed by MPST, TST, AGXT2cytosol, mitochondrial matrixOne of 3 routes

3-hydroxy-2-methylpropanoateReach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)

Catalysed by MPST, TST, AGXT2, HIBADHcytosol

2-phenylpropan-2-olReach from here →

thiosulfate:cyanide sulfurtranserase
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O

Catalysed by MPST, TST, TSTD1, CLIC2 and 3 moremitochondrial matrix

a hydroxy polyunsaturated fatty acidReach from here →

thiosulfate:cyanide sulfurtranserase
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O

Catalysed by MPST, TST, TSTD1, GPX1 and 2 moremitochondrial matrix

tauroursodeoxycholateReach from here →

thiosulfate:cyanide sulfurtranserase
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
tauroursodeoxycholate(in) + glutathione(in) + ATP + H2O = tauroursodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

Catalysed by MPST, TST, TSTD1, ABCC4mitochondrial matrix, inner side of the membrane, outer side of the membrane

glycoursodeoxycholateReach from here →

thiosulfate:cyanide sulfurtranserase
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
glycoursodeoxycholate(in) + glutathione(in) + ATP + H2O = glycoursodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

Catalysed by MPST, TST, TSTD1, ABCC4mitochondrial matrix, inner side of the membrane, outer side of the membrane

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

thiosulfate:cyanide sulfurtranserase
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + glutathione disulfide + H2O

Catalysed by MPST, TST, TSTD1, GPX1 and 1 moremitochondrial matrix

a quinoneReach from here →

thiosulfate:cyanide sulfurtranserase
transport of fumarate and sulfite (cytosol to mitochondria)
a quinone + succinate = fumarate + a quinol

Catalysed by MPST, TST, SLC25A10, SDHBmitochondrial matrix, cytosol

(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →

thiosulfate:cyanide sulfurtranserase
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate

Catalysed by MPST, TST, TSTD1, GSTP1 and 2 moremitochondrial matrix

pregnenolone sulfateReach from here →

thiosulfate:cyanide sulfurtranserase
sulfite:ferricytochrome-c oxidoreductase
Steryl-Sulfatase

Catalysed by MPST, TST, SUOX, STSmitochondrial matrix, cytosol, Golgi apparatusOne of 2 routes

androsterone 3alpha-sulfateReach from here →

thiosulfate:cyanide sulfurtranserase
sulfite:ferricytochrome-c oxidoreductase
steroid sulfatase (androsterone sulfate)

Catalysed by MPST, TST, SUOX, STSmitochondrial matrix, cytosolOne of 3 routes

prostaglandin E3Reach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
(S)-Lactate:NAD+ oxidoreductase
Transport of Prostaglandin E3, Lactate Antiport

Catalysed by MPST, TST, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 4 routes

prostaglandin A2Reach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
(S)-Lactate:NAD+ oxidoreductase
Transport of Prostaglandin A2, Lactate Antiport

Catalysed by MPST, TST, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

prostaglandin J2Reach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
(S)-Lactate:NAD+ oxidoreductase
Transport of Prostaglandin J2, Lactate Antiport

Catalysed by MPST, TST, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
(S)-Lactate:NAD+ oxidoreductase
Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport

Catalysed by MPST, TST, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

prostaglandin A2-S-(R)-glutathioneReach from here →

thiosulfate:cyanide sulfurtranserase
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
prostaglandin A2 + glutathione = prostaglandin A2-S-(R)-glutathione

Catalysed by MPST, TST, TSTD1, GSTA1 and 1 moremitochondrial matrix

prostaglandin A2-S-(S)-glutathioneReach from here →

thiosulfate:cyanide sulfurtranserase
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione

Catalysed by MPST, TST, TSTD1, GSTP1 and 1 moremitochondrial matrix

prostaglandin J2-S-(R)-glutathioneReach from here →

thiosulfate:cyanide sulfurtranserase
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
prostaglandin J2 + glutathione = prostaglandin J2-S-(R)-glutathione

Catalysed by MPST, TST, TSTD1, GSTA1 and 2 moremitochondrial matrix

prostaglandin J2-S-(S)-glutathioneReach from here →

thiosulfate:cyanide sulfurtranserase
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
prostaglandin J2 + glutathione = prostaglandin J2-S-(S)-glutathione

Catalysed by MPST, TST, TSTD1, GSTP1 and 1 moremitochondrial matrix

2,4-dinitrophenyl-S-glutathioneReach from here →

thiosulfate:cyanide sulfurtranserase
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)

Catalysed by MPST, TST, TSTD1, PTGES and 3 moremitochondrial matrix

all-trans-4-hydroxyretinoateReach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
transport of pyruvate and retinoate (cytosol to extracellular)
cytochrome P450 (retinoate)

Catalysed by MPST, TST, SLC16A4, SLC16A5 and 5 morecytosol, extracellular spaceOne of 3 routes

N-acetylcadaverineReach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
transport of acetate and pyruvate (cytosol to extracellular)
N-acetylcadaverine + H2O = cadaverine + acetate

Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

cholesterol sulfateReach from here →

thiosulfate:cyanide sulfurtranserase
sulfite:ferricytochrome-c oxidoreductase
Steryl-Sulfatase

Catalysed by MPST, TST, SUOX, STSmitochondrial matrix, cytosol, Golgi apparatusOne of 2 routes

5alpha-dihydrotestosterone sulfateReach from here →

thiosulfate:cyanide sulfurtranserase
sulfite:ferricytochrome-c oxidoreductase
steroid sulfatase (5-alpha-dihydrotestosterone)

Catalysed by MPST, TST, SUOX, STSmitochondrial matrix, cytosolOne of 3 routes

(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →

thiosulfate:cyanide sulfurtranserase
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate

Catalysed by MPST, TST, TSTD1, GSTM4 and 1 moremitochondrial matrix

all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
transport of pyruvate and retinoate (cytosol to extracellular)
glucuronosyltransferase (retinoate)

Catalysed by MPST, TST, SLC16A4, SLC16A5 and 7 morecytosol, extracellular space, endoplasmic reticulum

all-trans-18-hydroxyretinoateReach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
transport of pyruvate and retinoate (cytosol to extracellular)
unspecific monooxygenase (retinoate)

Catalysed by MPST, TST, SLC16A4, SLC16A5 and 29 morecytosol, extracellular spaceOne of 2 routes

a phenyl acetateReach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
transport of acetate and pyruvate (cytosol to extracellular)
a phenyl acetate + H2O = a phenol + acetate + H(+)

Catalysed by MPST, TST, SLC16A4, SLC16A5 and 6 morecytosol, extracellular space

an aryl sulfateReach from here →

thiosulfate:cyanide sulfurtranserase
sulfite:ferricytochrome-c oxidoreductase
an aryl sulfate + H2O = a phenol + sulfate + H(+)

Catalysed by MPST, TST, SUOX, ARSL and 5 moremitochondrial matrix, cytosol

S-methyl glutathioneReach from here →

thiosulfate:cyanide sulfurtranserase
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

Catalysed by MPST, TST, TSTD1, MMACHCmitochondrial matrix

S-adenosylglutathioneReach from here →

thiosulfate:cyanide sulfurtranserase
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
apo-[alkylcobalamin reductase] + adenosylcob(III)alamin + glutathione = S-adenosylglutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

Catalysed by MPST, TST, TSTD1, MMACHCmitochondrial matrix

CHEBI:15345Reach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
transport of acetoacetate and pyruvate (cytosol to mitochondria)
Acetoacetate:CoA ligase (AMP-forming)

Catalysed by MPST, TST, AACScytosol, mitochondrial matrixOne of 3 routes

acetoneReach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
transport of acetoacetate and pyruvate (cytosol to mitochondria)
Acetoacetate carboxy-lyase (acetone-forming)

Catalysed by MPST, TSTcytosol, mitochondrial matrix

propionyl-CoAReach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
2-Methyl-3-oxopropanoate:NAD+ oxidoreductase (CoA-propanoylating)

Catalysed by MPST, TST, AGXT2, ALDH6A1cytosol, mitochondrial matrixOne of 5 routes

CHEBI:15570Reach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
alanine racemase

Catalysed by MPST, TST, AGXT2cytosol, mitochondrial matrix

L-leucineReach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
transport of alanine and leucine (cytosol to extracellular)

Catalysed by MPST, TST, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 10 routes

10-formyltetrahydrofolic acidReach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
transport of formate and pyruvate (cytosol to extracellular)
Formate:tetrahydrofolate ligase (ADP-forming)

Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

CHEBI:15699Reach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
transport of alanine and homoserine (cytosol to extracellular)

Catalysed by MPST, TST, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 6 routes

malonateReach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
(S)-malate + NAD(+) = pyruvate + CO2 + NADH
malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)

Catalysed by MPST, TST, ME2, SLC25A10cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

CHEBI:15971Reach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
transport of alanine and histidine (cytosol to extracellular)

Catalysed by MPST, TST, AGXT2, SLC7A6cytosol, mitochondrial matrix, extracellular spaceOne of 4 routes

ferricytochrome cReach from here →

thiosulfate:cyanide sulfurtranserase
sulfite:ferricytochrome-c oxidoreductase
13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion

Catalysed by MPST, TST, SUOXmitochondrial matrix, cytosolOne of 4 routes

a halide anionReach from here →

thiosulfate:cyanide sulfurtranserase
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

Catalysed by MPST, TST, TSTD1, GSTT4 and 22 moremitochondrial matrix

CHEBI:16174Reach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
pyruvate kinase (dTDP)
nucleoside-diphosphate kinase (dADP)

Catalysed by MPST, TST, PKM, PKLR and 6 morecytosolOne of 3 routes

L-cystineReach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

Catalysed by MPST, TST, AGXT2, SLC7A9 and 1 morecytosol, mitochondrial matrix, extracellular space

CHEBI:16284Reach from here →

3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
pyruvate kinase (dTDP)
deoxythymidylate kinase (dADP)

Catalysed by MPST, TST, PKM, PKLR and 1 morecytosol, mitochondrial matrixOne of 3 routes