D-aspartic acid

Three steps

• octanoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by DDO, CS, CROTperoxisome, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. phytanate-CoA ligase

  Catalysed by DDO, CSperoxisome, mitochondrial matrix, cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by DDO, CS, SLC27A2, ACSL4 and 5 moreperoxisome, mitochondrial matrix, cytosolOne of 15 routes

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of aspartate (cytosol to extracellular)
  3. L-Citrulline:L-aspartate ligase (AMP-forming)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreextracellular space, cytosolOne of 2 routes

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of aspartate (cytosol to extracellular)
  3. IMP:L-aspartate ligase (GDP-forming)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreextracellular space, cytosolOne of 2 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. Oxaloacetate Decarboxylase
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by DDO, FAHD1, MPSTperoxisome, cytosol

• 2-methyl-3-oxopropanoateReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. Oxaloacetate Decarboxylase
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by DDO, FAHD1, AGXT2peroxisome, cytosol

• guanidinoacetateReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreextracellular space, cytosol

• sphing-4-enineReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by DDO, CS, ASAH1, ACER2 and 2 moreperoxisome, mitochondrial matrix, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by DDO, CS, SAT1, SAT2peroxisome, mitochondrial matrix, cytosolOne of 3 routes

• L-methionineReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of chloride and methionine (cytosol to extracellular)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosolOne of 6 routes

• L-tryptophanReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. Transport of L-Tryptophan by Atb0 Transporter

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosolOne of 4 routes

• beta-alanineReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 5 moreextracellular space, cytosolOne of 4 routes

• L-alanineReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of alanine and chloride (cytosol to extracellular)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosolOne of 22 routes

• L-asparagineReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. Transport of L-Asparagine by Atb0 Transporter

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosolOne of 5 routes

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of aspartate (cytosol to extracellular)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreextracellular space, cytosol

• L-phenylalanineReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. Transport of L-Phenylalanine by Atb0 Transporter

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosolOne of 4 routes

• L,L-cystathionineReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by DDO, CS, NAGSperoxisome, mitochondrial matrix

• (2R)-2-phosphoglycerateReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. GTP:oxaloacetate carboxy-lyase (adding GTP
  3. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)

  Catalysed by DDO, PCK1, ENO1, ENO2 and 1 moreperoxisome, cytosolOne of 2 routes

• L-tyrosineReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of aspartate (cytosol to extracellular)
  3. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of aspartate (cytosol to extracellular)
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreextracellular space, cytosolOne of 7 routes

• an acyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by DDO, CS, ASAH1, ACER2 and 2 moreperoxisome, mitochondrial matrix, Golgi apparatusOne of 2 routes

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of aspartate (cytosol to extracellular)
  3. 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreextracellular space, cytosolOne of 2 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by DDO, CS, HADHA, ACAA2 and 1 moreperoxisome, mitochondrial matrixOne of 3 routes

• (3S)-citramalyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. Oxaloacetate Decarboxylase
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by DDO, FAHD1, CLYBLperoxisome, cytosol

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by DDO, CS, SLC27A2, SLC27A5peroxisome, mitochondrial matrix, endoplasmic reticulumOne of 3 routes

• 5-amino-2-oxopentanoateReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. Oxaloacetate Decarboxylase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by DDO, FAHD1, AGXT2peroxisome, cytosol

• deoxycholoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by DDO, CS, SLC27A2, SLC27A5peroxisome, mitochondrial matrix, cytosolOne of 4 routes

• 4-aminobutanoateReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosolOne of 4 routes

• 3-sulfino-L-alanineReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of aspartate (cytosol to extracellular)
  3. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreextracellular space, cytosol, mitochondrial matrixOne of 4 routes

• decanoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by DDO, CS, ACSM4, ACSM1 and 4 moreperoxisome, mitochondrial matrix, cytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by DDO, CS, CPT1A, CPT1C and 1 moreperoxisome, mitochondrial matrix, cytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moreperoxisome, mitochondrial matrix, cytosolOne of 11 routes

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. Oxaloacetate Decarboxylase
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by DDO, FAHD1, HOGA1peroxisome, cytosol

• 3-hydroxyisovaleryl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by DDO, CS, CPT1A, CPT1Bperoxisome, mitochondrial matrix, cytosol

• CHEBI:63544Reach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moreperoxisome, mitochondrial matrix, cytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moreperoxisome, mitochondrial matrix, cytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moreperoxisome, mitochondrial matrix, cytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moreperoxisome, mitochondrial matrix, cytosolOne of 9 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by DDO, CS, CPT1A, CPT1C and 1 moreperoxisome, mitochondrial matrix, cytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moreperoxisome, mitochondrial matrix, cytosolOne of 8 routes

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. Oxaloacetate Decarboxylase
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by DDO, FAHD1, HOGA1peroxisome, cytosol

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moreperoxisome, mitochondrial matrix, cytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moreperoxisome, mitochondrial matrix, cytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moreperoxisome, mitochondrial matrix, cytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moreperoxisome, mitochondrial matrix, cytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moreperoxisome, mitochondrial matrix, cytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moreperoxisome, mitochondrial matrix, cytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moreperoxisome, mitochondrial matrix, cytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moreperoxisome, mitochondrial matrix, cytosolOne of 6 routes