(R)-lactaldehyde

Three steps

• 5'-deoxyadenosineReach from here →
  1. Lactaldehyde Dehydrogenase, Mitochondrial
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 5 moremitochondrial matrix, cytosol

• sulfiteReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 5 morecytosolOne of 2 routes

• L-cysteineReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-Lactoylglutathione hydrolase
  3. cystine to cysteine conversion

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 5 morecytosol

• urateReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  3. urate(out) + glutathione(in) = urate(in) + glutathione(out)

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 5 morecytosol, inner side of the membrane, outer side of the membrane

• methylarsonous acidReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 6 morecytosol

• dTDPReach from here →
  1. Lactaldehyde Dehydrogenase, Mitochondrial
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. pyruvate kinase (dTDP)

  Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 5 moremitochondrial matrix, cytosol

• arsenic triglutathioneReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 5 morecytosolOne of 3 routes

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 5 morecytosol

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 6 morecytosol

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 6 morecytosol

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 6 morecytosol

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 6 morecytosol

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 5 morecytosol

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. Lactaldehyde Dehydrogenase, Mitochondrial
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 4 moremitochondrial matrix, cytosol

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. Lactaldehyde Dehydrogenase, Mitochondrial
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 4 moremitochondrial matrix, cytosol

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. Lactaldehyde Dehydrogenase, Mitochondrial
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 4 moremitochondrial matrix, cytosol

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 5 morecytosol

• a quinolReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 5 morecytosol

• 5(S)-HETEReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-Lactoylglutathione hydrolase
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 14 morecytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-Lactoylglutathione hydrolase
  3. transport of GSH and LTD4 (cytosol to extracellular)

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 6 morecytosol, extracellular spaceOne of 2 routes

• L-ascorbic acidReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 7 morecytosol

• glycocholateReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-Lactoylglutathione hydrolase
  3. solute carrier organic anion transporter (glycocholate)

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 7 morecytosol, extracellular spaceOne of 3 routes

• cholateReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-Lactoylglutathione hydrolase
  3. solute carrier organic anion transporter (cholate)

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 7 morecytosol, extracellular spaceOne of 3 routes

• hydrogen sulfideReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 5 morecytosol

• acetateReach from here →
  1. Lactaldehyde Dehydrogenase, Mitochondrial
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 8 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• formic acidReach from here →
  1. Lactaldehyde Dehydrogenase, Mitochondrial
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 8 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• propionic acidReach from here →
  1. Lactaldehyde Dehydrogenase, Mitochondrial
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 9 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• butyric acidReach from here →
  1. Lactaldehyde Dehydrogenase, Mitochondrial
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 9 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. Lactaldehyde Dehydrogenase, Mitochondrial
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. L-Serine:pyruvate aminotransferase

  Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 4 moremitochondrial matrix, cytosolOne of 2 routes

• an alcoholReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 6 morecytosol

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-Lactoylglutathione hydrolase
  3. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 5 morecytosol, extracellular spaceOne of 2 routes

• 3-oxopropanoateReach from here →
  1. Lactaldehyde Dehydrogenase, Mitochondrial
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 4 moremitochondrial matrix, cytosol

• serotoninReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-Lactoylglutathione hydrolase
  3. transport of GSH and serotonin (cytosol to extracellular)

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 7 morecytosol, extracellular spaceOne of 2 routes

• D-serineReach from here →
  1. Lactaldehyde Dehydrogenase, Mitochondrial
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. D-serine = pyruvate + NH4(+)

  Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 4 moremitochondrial matrix, cytosol

• glycochenodeoxycholateReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  3. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 5 morecytosol, inner side of the membrane, outer side of the membrane

• taurocholateReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-Lactoylglutathione hydrolase
  3. solute carrier organic anion transporter (GSH)

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 7 morecytosol, extracellular spaceOne of 3 routes

• glycolithocholic acidReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-Lactoylglutathione hydrolase
  3. transport of glycolithocholate and GSH (cytosol to extracellular)

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 7 morecytosol, extracellular spaceOne of 2 routes

• (S)-lactic acidReach from here →
  1. Lactaldehyde Dehydrogenase, Mitochondrial
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. (S)-Lactate:NAD+ oxidoreductase

  Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 5 moremitochondrial matrix, cytosolOne of 5 routes

• 2-iminopropanoateReach from here →
  1. Lactaldehyde Dehydrogenase, Mitochondrial
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 4 moremitochondrial matrix, cytosol

• phosphoenolpyruvic acidReach from here →
  1. Lactaldehyde Dehydrogenase, Mitochondrial
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. pyruvate kinase (dTDP)

  Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 5 moremitochondrial matrix, cytosol

• N-acetyl-beta-neuraminic acidReach from here →
  1. Lactaldehyde Dehydrogenase, Mitochondrial
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 4 moremitochondrial matrix, cytosol

• tert-butanolReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 9 morecytosol

• gamma-Glu-AlaReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-Lactoylglutathione hydrolase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 11 morecytosol, extracellular space

• 3,3',5-triiodo-L-thyronineReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-Lactoylglutathione hydrolase
  3. transport of GSH and triiodothyronine (cytosol to extracellular)

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 7 morecytosol, extracellular spaceOne of 2 routes

• a 3-acylpyruvateReach from here →
  1. Lactaldehyde Dehydrogenase, Mitochondrial
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by ALDH2, ALDH4A1, ALDH1B1, ALDH5A1 and 4 moremitochondrial matrix, cytosol

• prostaglandin E1Reach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-Lactoylglutathione hydrolase
  3. transport of GSH and prostaglandin E1 (cytosol to extracellular)

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 6 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin I2Reach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-Lactoylglutathione hydrolase
  3. transport of GSH and prostaglandin I2 (cytosol to extracellular)

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 6 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-Lactoylglutathione hydrolase
  3. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 6 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin H2Reach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-Lactoylglutathione hydrolase
  3. transport of GSH and prostaglandin H2 (cytosol to extracellular)

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 6 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin D2Reach from here →
  1. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
  2. (R)-S-Lactoylglutathione hydrolase
  3. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by ADH1C, ADH1A, ADH4, ADH5 and 6 morecytosol, extracellular spaceOne of 2 routes