ferrocytochrome c

Three steps

• oxalateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. sulfite:ferricytochrome-c oxidoreductase
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC26A2, SLC25A30 and 2 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• formic acidReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A7 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• propionic acidReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• butyric acidReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• maleateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. sulfite:ferricytochrome-c oxidoreductase
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC25A30cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• malonic acidReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. sulfite:ferricytochrome-c oxidoreductase
  3. transport of malonate and sulfate (cytosol to mitochondria)

  Catalysed by SUOX, SLC25A10cytosol, mitochondrial matrixOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. L-Serine:pyruvate aminotransferase

  Catalysed by LDHD, AGXTcytosol, mitochondrial matrixOne of 2 routes

• (2R,3R)-tartrateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. sulfite:ferricytochrome-c oxidoreductase
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC25A30cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. sulfite:ferricytochrome-c oxidoreductase
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC25A30cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. sulfite:ferricytochrome-c oxidoreductase
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC25A30cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. sulfite:ferricytochrome-c oxidoreductase
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC25A30cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-oxopropanoateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by LDHD, AGXT2cytosol, mitochondrial matrix

• methylarsonateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by GPX1, GSTA1, GPX2, GPX4 and 2 morecytosol

• thiosulfateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by GPX1, GSTA1, GPX2, GPX4 and 1 morecytosolOne of 3 routes

• D-serineReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. D-serine = pyruvate + NH4(+)

  Catalysed by LDHD, SRRcytosol, mitochondrial matrix

• (R)-lactic acidReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by LDHDcytosol, mitochondrial matrix

• (S)-lactic acidReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. (S)-Lactate:NAD+ oxidoreductase

  Catalysed by LDHD, LDHB, LDHAL6Bcytosol, mitochondrial matrixOne of 5 routes

• 2-iminopropanoateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by LDHD, RIDAcytosol, mitochondrial matrix

• phosphoenolpyruvic acidReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. pyruvate kinase (dTDP)

  Catalysed by LDHD, PKM, PKLRcytosol, mitochondrial matrix

• N-acetyl-beta-neuraminic acidReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by LDHD, NPLcytosol, mitochondrial matrix

• a 3-acylpyruvateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by LDHD, FAHD1cytosol, mitochondrial matrix

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by LDHD, MPSTcytosol, mitochondrial matrix

• 2-methyl-3-oxopropanoateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by LDHD, AGXT2cytosol, mitochondrial matrix

• L-methionineReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by LDHD, TYW1B, TYW1cytosol, mitochondrial matrix

• N-sulfo-D-glucosamineReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. sulfite:ferricytochrome-c oxidoreductase
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SUOX, SGSHcytosol, mitochondrial matrix

• dehydroepiandrosterone 3-sulfateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. sulfite:ferricytochrome-c oxidoreductase
  3. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)

  Catalysed by SUOX, STScytosol, mitochondrial matrix

• glutathioneReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
  3. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)

  Catalysed by GPX1, GSTA1, GPX2, GPX4 and 1 morecytosolOne of 4 routes

• L-alanineReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by LDHD, AGXT2cytosol, mitochondrial matrixOne of 18 routes

• adenosine 5'-phosphosulfateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. sulfite:ferricytochrome-c oxidoreductase
  3. ATP:sulfate adenylyltransferase

  Catalysed by SUOX, PAPSS1, PAPSS2cytosol, mitochondrial matrixOne of 4 routes

• (3S)-citramalyl-CoAReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by LDHD, CLYBLcytosol, mitochondrial matrix

• 5-amino-2-oxopentanoateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by LDHD, AGXT2cytosol, mitochondrial matrix

• estrone 3-sulfateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. sulfite:ferricytochrome-c oxidoreductase
  3. estrone 3-sulfate + H2O = estrone + sulfate + H(+)

  Catalysed by SUOX, STScytosol, mitochondrial matrix

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by LDHD, HOGA1cytosol, mitochondrial matrix

• (5-hydroxyindol-3-yl)acetateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. sulfite:ferricytochrome-c oxidoreductase
  3. Transport of 5-Hydroxyindoleacetate

  Catalysed by SUOX, SLC4A1cytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by LDHD, HOGA1cytosol, mitochondrial matrix

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by LDHD, PDHA1, PDHB, PDHA2cytosol, mitochondrial matrix