(S)-lactate

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. D-serine = pyruvate + NH4(+)

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 more

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. (R)-Lactate:NAD+ oxidoreductase

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 morecytosol

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. (S)-Lactate:NAD+ oxidoreductase

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 1 moremitochondrial matrixOne of 8 routes

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. 2-iminopropanoate + H2O = pyruvate + NH4(+)

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 more

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. pyruvate kinase (dTDP)

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 3 morecytosol

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 morecytosol

1. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)
2. thromboxane A synthase (12(S)-HHT)

Catalysed by SLCO2A1, TBXAS1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 more

1. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)
2. prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)

Catalysed by SLCO2A1, HPGDinner side of the membrane, outer side of the membraneOne of 2 routes

1. prostaglandin E1(out) + 2 (S)-lactate(in) = prostaglandin E1(in) + 2 (S)-lactate(out)
2. (13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase

Catalysed by SLCO2A1, CBR3, CBR1, DHRS4inner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

1. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)
2. prostaglandin I2 synthase (prostaglandin H2)

Catalysed by SLCO2A1, PTGISinner side of the membrane, outer side of the membrane, endoplasmic reticulumOne of 2 routes

1. prostaglandin D2(out) + 2 (S)-lactate(in) = prostaglandin D2(in) + 2 (S)-lactate(out)
2. 15-dehydro-prostaglandin D2 reduction

Catalysed by SLCO2A1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

1. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)
2. thromboxane A synthase (prostaglandin H2)

Catalysed by SLCO2A1, TBXAS1inner side of the membrane, outer side of the membrane, endoplasmic reticulumOne of 4 routes

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 more

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 more

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 3 more

1. urate(out) + (S)-lactate(in) = urate(in) + (S)-lactate(out)
2. urate(out) + glutathione(in) = urate(in) + glutathione(out)

Catalysed by SLC22A12, SLC22A13inner side of the membrane, outer side of the membrane

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 moremitochondrial matrixOne of 18 routes

1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
2. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

Catalysed by CNDP2

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 more

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 more

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 more

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 more

1. urate(out) + (S)-lactate(in) = urate(in) + (S)-lactate(out)
2. Peroxidase

Catalysed by SLC22A12, SLC22A13, MPOinner side of the membrane, outer side of the membrane, nucleusOne of 3 routes

1. prostaglandin D2(out) + 2 (S)-lactate(in) = prostaglandin D2(in) + 2 (S)-lactate(out)
2. prostaglandin D2 + NADPH + H(+) = 11beta-prostaglandin F2 + NADP(+)

Catalysed by SLCO2A1, AKR1C3, AKR1C2inner side of the membrane, outer side of the membrane

1. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)
2. prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde

Catalysed by SLCO2A1, TBXAS1, CYP2S1, PTGES2inner side of the membrane, outer side of the membrane

1. prostaglandin E1(out) + 2 (S)-lactate(in) = prostaglandin E1(in) + 2 (S)-lactate(out)
2. prostaglandin-E synthase (prostaglandin E1)

Catalysed by SLCO2A1, PTGES, PTGES3, PTGES2inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

1. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)
2. prostaglandin H2 + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxyprostaglandin H2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO2A1, CYP4F8inner side of the membrane, outer side of the membrane

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 4 moremitochondrial matrix

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
3. (S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 moremitochondrial matrix, cytosol

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)