CHEBI:15611

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

448 compounds within 3 steps: 4 in 1, 80 in 2, 364 in 3

Two steps

glycocholateReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. bile acid-CoA: amino acid N-acyltransferase
Catalysed by PIPOX, SARDH, BAATperoxisomeOne of 3 routes
5-aminolevulinateReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA
Catalysed by PIPOX, SARDH, ALAS1, ALAS2peroxisome
glycochenodeoxycholateReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)
Catalysed by PIPOX, SARDH, BAATperoxisome
glycochenodeoxycholic acidReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. bile acid-CoA: amino acid N-acyltransferase
Catalysed by PIPOX, SARDH, BAATperoxisomeOne of 3 routes
glyoxylateReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
Catalysed by PIPOX, SARDH, AADATperoxisomeOne of 11 routes
glycolithocholic acidReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. bile acid-CoA:amino acid N-acyltransferase (glycine)
Catalysed by PIPOX, SARDH, BAATperoxisome, cytosolOne of 2 routes
L-2-amino-3-oxobutanoic acidReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. Acetyl-CoA:glycine C-acetyltransferase
Catalysed by PIPOX, SARDH, GCATperoxisome, mitochondrial matrix
L-ornithineReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. L-Arginine:glycine amidinotransferase
Catalysed by PIPOX, SARDH, GATMperoxisome, cytosolOne of 5 routes
S(8)-aminomethyldihydrolipoamideReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)
Catalysed by PIPOX, SARDH, GLDC, GCSHperoxisome, mitochondrial matrix
sarcosineReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
Catalysed by PIPOX, SARDHperoxisomeOne of 3 routes
7,8-dihydrofolateReach from here →
1. sarcosine dehydrogenase (sarcosine)
2. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
Catalysed by SARDH, TYMSmitochondrial matrix, cytosol
(6S)-5,6,7,8-tetrahydrofolateReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
Catalysed by PIPOX, SARDH, SHMT1, SHMT2peroxisome
(6R)-5,10-methenyltetrahydrofolateReach from here →
1. sarcosine dehydrogenase (sarcosine)
2. 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase
Catalysed by SARDH, MTHFD2, MTHFD2Lmitochondrial matrixOne of 4 routes
an N-acylglycineReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)
Catalysed by PIPOX, SARDH, GLYATL3, GLYAT and 1 moreperoxisome
S-formylglutathioneReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. alcohol dehydrogenase (formaldehyde)
Catalysed by PIPOX, SARDH, ADH1C, ADH1A and 4 moreperoxisome, cytosol
guanidinoacetateReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. L-Arginine:glycine amidinotransferase
Catalysed by PIPOX, SARDH, GATMperoxisome, cytosolOne of 2 routes
L-methionineReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. transport of glycine and methionine (cytosol to extracellular)
Catalysed by PIPOX, SARDH, SLC7A5peroxisome, extracellular space, cytosolOne of 5 routes
L-tryptophanReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. transport of glycine and tryptophan (cytosol to extracellular)
Catalysed by PIPOX, SARDH, SLC7A5peroxisome, extracellular space, cytosolOne of 5 routes
glutathioneReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
Catalysed by PIPOX, SARDH, GSSperoxisome
L-alanineReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. transport of alanine and glycine (cytosol to extracellular)
Catalysed by PIPOX, SARDH, SLC3A2, SLC7A5 and 1 moreperoxisome, extracellular space, cytosolOne of 6 routes
leukotriene C4Reach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. leukotriene C4 hydrolysis
Catalysed by PIPOX, SARDHperoxisome, cytosol
L-asparagineReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. transport of asparagine and glycine (cytosol to extracellular)
Catalysed by PIPOX, SARDHperoxisome, extracellular space, cytosolOne of 4 routes
L-phenylalanineReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. transport of glycine and phenylalanine (cytosol to extracellular)
Catalysed by PIPOX, SARDH, SLC7A5peroxisome, extracellular space, cytosolOne of 7 routes
L-tyrosineReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
Catalysed by PIPOX, SARDH, AADATperoxisome
N(omega),N(omega)-dimethyl-L-arginineReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
Catalysed by PIPOX, SARDH, AGXT2peroxisome
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
Catalysed by PIPOX, SARDH, GLYATL2peroxisomeOne of 2 routes
N-benzoylglycineReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. Hippurate (Benzoylglycinate) Formation
Catalysed by PIPOX, SARDHperoxisome, mitochondrial matrixOne of 2 routes
dTMPReach from here →
1. sarcosine dehydrogenase (sarcosine)
2. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
Catalysed by SARDH, TYMSmitochondrial matrix, cytosol
(2S)-2-aminobutanoateReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
Catalysed by PIPOX, SARDH, AGXT2peroxisome
glycodeoxycholateReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. Glycodeoxycholate amidohydrolase
Catalysed by PIPOX, SARDHperoxisome, cytosolOne of 2 routes
N-tetradecanoylglycineReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
Catalysed by PIPOX, SARDH, GLYATL2peroxisome
N-eicosanoylglycinateReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)
Catalysed by PIPOX, SARDH, BAATperoxisome
N-docosanoylglycineReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)
Catalysed by PIPOX, SARDH, BAATperoxisome
N-hexacosanoylglycineReach from here →
1. sarcosine:oxygen oxidoreductase (demethylating)
2. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)
Catalysed by PIPOX, SARDH, BAATperoxisome

Three steps

beta-carbolineReach from here →
Catalysed by PIPOX, SARDH, SLC7A5peroxisome, extracellular space, cytosol
(S)-carnitineReach from here →
Catalysed by PIPOX and 2 more