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Proteins/UNIPROT:Q99536
Multifunctional protein with enzymatic and transport activities. Probable NADPH-dependent quinone oxidoreductase which physiological substrates and function are unclear. Alternatively, has also been suggested to mediate the transfer of negatively charged phospholipids including phosphatidic acid (PA), phosphatidylserine (PS) and phosphatidylglycerol (PG) between endoplasmic reticulum and mitochondrial membranes. Could regulate mitochondrial fusion through its interaction with mitofusins..
Function from UniProtKB (Q99536), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
605 statements
605 statements · 5 reference databases · Subject: VAT1 · Sources: Bgee, gene ontology, Hetionet, Reactome, Rhea · Rows fetched: 300
6 reactions
2a quinone+NADPH(4-)+hydron2a 1,4-benzosemiquinone+NADP(3-)
Catalysed by CRYZ or TP53I3 or VAT1 or VAT1L
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:14269CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphatea 1,2-diacyl-sn-glycero-3-phosphate
Transported by TRIAP1 or
5 names
Resolves to: VAT1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:36435CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-L-serinea 1,2-diacyl-sn-glycero-3-phospho-L-serine
Transported by ANO9 or PLSCR1 or VDAC1 or VDAC2 or SERINC3 or ATG2A or ANO4 or ANO6 or TMEM41B or XKR9 or XKR4 or ATG9B and 11 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:38663CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)
Transported by PLTP or VAT1 or PLSCR3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:39743CC BY 4.0Reference data
2CHEBI:34055+NADPH(4-)+hydron2CHEBI:234268+NADP(3-)
Catalysed by CRYZ or TP53I3 or VAT1
Reaction pageLeft to rightBalanced
Rhea RHEA:85243CC BY 4.0Reference data
2CHEBI:37454+NADPH(4-)+hydron2CHEBI:234267+NADP(3-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:85247CC BY 4.0Reference data