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Proteins/UNIPROT:Q2TAZ0
Lipid transfer protein involved in autophagosome assembly. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion. Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Also regulates lipid droplets morphology and distribution within the cell..
Function from UniProtKB (Q2TAZ0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
28 statements
28 statements · 4 reference databases · Subject: ATG2A · Sources: gene ontology, Hetionet, Rhea, WikiPathways
2 reactions
a 1,2-diacyl-sn-glycero-3-phospho-L-serinea 1,2-diacyl-sn-glycero-3-phospho-L-serine
Transported by ANO9 or PLSCR1 or VDAC1 or VDAC2 or SERINC3 or ATG2A or ANO4 or ANO6 or TMEM41B or XKR9 or XKR4 or ATG9B and 11 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:38663CC BY 4.0Reference data
2 names
Resolves to: ATG2A
a 1,2-diacyl-sn-glycero-3-phosphoethanolaminea 1,2-diacyl-sn-glycero-3-phosphoethanolamine
Transported by PLSCR1 or PLTP or MTTP or SERINC3 or ATG2A or TMEM41B or ATG9B or ATG9A or SERINC5 or ATG2B or VMP1 or CLPTM1L and 2 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:38895CC BY 4.0Reference data