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Proteins/UNIPROT:Q96G46
Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs. Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation..
Function from UniProtKB (Q96G46), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
14 statements
14 statements · 3 reference databases · Subject: DUS3L · Sources: gene ontology, Hetionet, UniProt
4 reactions
CHEBI:74443+NADP(3-)CHEBI:65315+NADPH(4-)+hydron
Catalysed by DUS3L
Reaction pageRight to leftBalanced
Rhea RHEA:53360CC BY 4.0Reference data
CHEBI:74443+NAD(1-)CHEBI:65315+NADH(2-)+hydron
Catalysed by DUS3L
Reaction pageRight to leftBalanced
Rhea RHEA:53364CC BY 4.0Reference data
5 names
Resolves to: DUS3L
a 5,6-dihydrouridine in mRNA+NAD(1-)a uridine in mRNA+NADH(2-)+hydron
Catalysed by DUS3L
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:69851CC BY 4.0Reference data
a 5,6-dihydrouridine in mRNA+NADP(3-)a uridine in mRNA+NADPH(4-)+hydron
Catalysed by DUS3L
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:69855CC BY 4.0Reference data