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Proteins/UNIPROT:P36894
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity)..
Function from UniProtKB (P36894), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 rows
113 statements
113 statements · 5 reference databases · Subject: BMPR1A · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways
2 reactions
10 names
Resolves to: BMPR1A
Rhea RHEA:18673CC BY 4.0Reference data
L-threonyl-[receptor-protein]+ATP(4-)O-phospho-L-threonyl-[receptor-protein]+ADP(3-)+hydron
Catalysed by BMPR1B or ACVR2A or BMPR1A or ACVR1B or TGFBR1 or ACVRL1 or TGFBR2 or ACVR1 or ACVR2B or BMPR2 or AMHR2 or ACVR1C
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:44880CC BY 4.0Reference data