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Proteins/UNIPROT:Q4KMQ2
Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization (By similarity). Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes (By similarity)..
(Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia..
Function from UniProtKB (Q4KMQ2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
72 statements
72 statements · 6 reference databases · Subject: ANO6 · Sources: Bgee, gene ontology, Hetionet, Reactome, Rhea, WikiPathways
3 reactions
a 1,2-diacyl-sn-glycero-3-phosphocholinea 1,2-diacyl-sn-glycero-3-phosphocholine
Transported by ANO9 or PLSCR1 or VDAC1 or VDAC2 or PITPNB or PLTP or MTTP or PITPNA or SERINC3 or ANO4 or ANO6 or TMEM41B and 14 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:38571CC BY 4.0Reference data
4 names
Resolves to: ANO6
a 1,2-diacyl-sn-glycero-3-phospho-L-serinea 1,2-diacyl-sn-glycero-3-phospho-L-serine
Transported by ANO9 or PLSCR1 or VDAC1 or VDAC2 or SERINC3 or ATG2A or ANO4 or ANO6 or TMEM41B or XKR9 or XKR4 or ATG9B and 11 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:38663CC BY 4.0Reference data
a beta-D-galactosyl-(1<->1')-N-acylsphing-4-eninea beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine
Transported by ANO9 or ANO4 or ANO6 or ANO7 or ANO3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:38899CC BY 4.0Reference data