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Proteins/UNIPROT:Q9NRY6
Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria. Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response. Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis. Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases. Regulates cardiolipin de novo biosynthesis and its resynthesis..
Function from UniProtKB (Q9NRY6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
162 statements
162 statements · 7 reference databases · Subject: PLSCR3 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Rhea, UniProt, WikiPathways
5 reactions
a 1,2-diacyl-sn-glycero-3-phosphocholinea 1,2-diacyl-sn-glycero-3-phosphocholine
Transported by ANO9 or PLSCR1 or VDAC1 or VDAC2 or PITPNB or PLTP or MTTP or PITPNA or SERINC3 or ANO4 or ANO6 or TMEM41B and 14 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:38571CC BY 4.0Reference data
2 names
Resolves to: PLSCR3
a 1,2-diacyl-sn-glycero-3-phospho-L-serinea 1,2-diacyl-sn-glycero-3-phospho-L-serine
Transported by ANO9 or PLSCR1 or VDAC1 or VDAC2 or SERINC3 or ATG2A or ANO4 or ANO6 or TMEM41B or XKR9 or XKR4 or ATG9B and 11 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:38663CC BY 4.0Reference data
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:38695CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphoethanolaminea 1,2-diacyl-sn-glycero-3-phosphoethanolamine
Transported by PLSCR1 or PLTP or MTTP or SERINC3 or ATG2A or TMEM41B or ATG9B or ATG9A or SERINC5 or ATG2B or VMP1 or CLPTM1L and 2 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:38895CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)
Transported by PLTP or VAT1 or PLSCR3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:39743CC BY 4.0Reference data