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Proteins/UNIPROT:Q5BJD5
Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes. Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine. Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly. In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required. Required for normal motor neuron development (By similarity)..
(Microbial infection) Critical host factor required for infection by human coronaviruses SARS-CoV-2, HCoV-OC43, HCoV-NL63, and HCoV-229E, as well as all flaviviruses tested such as Zika virus and Yellow fever virus. Required post-entry of the virus to facilitate the ER membrane remodeling necessary to form replication organelles..
Function from UniProtKB (Q5BJD5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
23 statements
23 statements · 4 reference databases · Subject: TMEM41B · Sources: Bgee, Hetionet, Rhea, WikiPathways
4 reactions
a 1,2-diacyl-sn-glycero-3-phosphocholinea 1,2-diacyl-sn-glycero-3-phosphocholine
Transported by ANO9 or PLSCR1 or VDAC1 or VDAC2 or PITPNB or PLTP or MTTP or PITPNA or SERINC3 or ANO4 or ANO6 or TMEM41B and 14 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:38571CC BY 4.0Reference data
4 names
Resolves to: TMEM41B
a 1,2-diacyl-sn-glycero-3-phospho-L-serinea 1,2-diacyl-sn-glycero-3-phospho-L-serine
Transported by ANO9 or PLSCR1 or VDAC1 or VDAC2 or SERINC3 or ATG2A or ANO4 or ANO6 or TMEM41B or XKR9 or XKR4 or ATG9B and 11 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:38663CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphoethanolaminea 1,2-diacyl-sn-glycero-3-phosphoethanolamine
Transported by PLSCR1 or PLTP or MTTP or SERINC3 or ATG2A or TMEM41B or ATG9B or ATG9A or SERINC5 or ATG2B or VMP1 or CLPTM1L and 2 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:38895CC BY 4.0Reference data