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Proteins/UNIPROT:A1A5B4
PKA-activated nonselective cation channel. Discriminates poorly among cations but is more permeable to Ca(2+) ions than to monovalent cations (By similarity). Acts as a calcium-activated calcium permeable channel which may operate as a endoplasmic reticulum (ER) Ca(2+)-leak channel, reducing the loading of the ER Ca(2+) store. Regulates intracellular Ca2+ signals, ion channel activity, and cytokine release in the renal tissue. Plays an important role in olfaction, amplifying cAMP-evoked cyclic nucleotide-gated (CNG) channel currents in the olfactory sensory neurons (By similarity). Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1..
Function from UniProtKB (A1A5B4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
20 statements
20 statements · 4 reference databases · Subject: ANO9 · Sources: Bgee, Hetionet, Reactome, Rhea
6 reactions
6 names
Resolves to: ANO9
Transported by ANO9 or HTR3E or TMEM150C or CACNA1A or GRIN2D or P2RX6 or GRID2 or CACNA1G or GRIN3B or CACNA1F or TRPA1 or TRPM2 and 106 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29671CC BY 4.0Reference data
Transported by ANO9 or HTR3E or TMEM150C or KCNK1 or KCNK3 or GRIN2D or GRID2 or KCNQ3 or KCNQ2 or GRIN3B or HCN1 or TRPA1 and 98 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:34963CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphocholinea 1,2-diacyl-sn-glycero-3-phosphocholine
Transported by ANO9 or PLSCR1 or VDAC1 or VDAC2 or PITPNB or PLTP or MTTP or PITPNA or SERINC3 or ANO4 or ANO6 or TMEM41B and 14 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:38571CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-L-serinea 1,2-diacyl-sn-glycero-3-phospho-L-serine
Transported by ANO9 or PLSCR1 or VDAC1 or VDAC2 or SERINC3 or ATG2A or ANO4 or ANO6 or TMEM41B or XKR9 or XKR4 or ATG9B and 11 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:38663CC BY 4.0Reference data
a beta-D-galactosyl-(1<->1')-N-acylsphing-4-eninea beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine
Transported by ANO9 or ANO4 or ANO6 or ANO7 or ANO3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:38899CC BY 4.0Reference data