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Proteins/UNIPROT:P52824
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription. Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis..
Function from UniProtKB (P52824), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
59 statements
59 statements · 7 reference databases · Subject: DGKQ · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
8 reactions
5 names
Resolves to: DGKQ
a 1,2-diacyl-sn-glycerol+ATP(4-)a 1,2-diacyl-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or AGK or DGKK or DGKH or DGKB
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:10272CC BY 4.0Reference data
a 1-O-alkyl-sn-glycerol+ATP(4-)a 1-O-alkyl-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKA or DGKQ or DGKZ
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:16937CC BY 4.0Reference data
1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol+ATP(4-)1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or DGKB
Reaction pageLeft to rightBalanced
Rhea RHEA:40323CC BY 4.0Reference data
1,2-di-(9Z-octadecenoyl)-sn-glycerol+ATP(4-)1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or AGK or DGKK or DGKH or DGKB
Reaction pageLeft to rightBalanced
Rhea RHEA:40327CC BY 4.0Reference data
1-O-hexadecyl-sn-glycerol+ATP(4-)1-O-hexadecyl-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKA or DGKQ or DGKZ
Reaction pageLeft to rightBalanced
Rhea RHEA:41672CC BY 4.0Reference data
1-O-hexadecyl-2-acetyl-sn-glycerol+ATP(4-)1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKA or DGKQ or DGKZ
Reaction pageLeft to rightBalanced
Rhea RHEA:41676CC BY 4.0Reference data
1-O-alkyl-2-acyl-sn-glycerol+ATP(4-)CHEBI:73332+ADP(3-)+hydron
Catalysed by DGKA or DGKQ or DGKZ
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:44072CC BY 4.0Reference data