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Reach

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

222 compounds within 3 steps: 2 in 1, 49 in 2, 171 in 3

Does it reach a compound?

Two steps

1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholineReach from here →
1. 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
2. eicosanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by PLA2G7, LPCAT1

Three steps

(S)-3-hydroxybutanoateReach from here →
Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A6 and 3 moreextracellular space, cytosol
CHEBI:1146900Reach from here →

Page 2 of 5

Catalysed by PLA2G7, ENPP2, GDPD3, GDPD1 and 1 morecytosolOne of 2 routes

1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholineReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by PLA2G7, TAFAZZIN, CYP2W1

1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholineReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by PLA2G7, TAFAZZIN, CYP2W1

1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholineReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by PLA2G7, TAFAZZIN, CYP2W1

1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholineReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by PLA2G7, TAFAZZIN, CYP2W1

prostaglandin E3Reach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and L-lactate (cytosol to extracellular)
Transport of Prostaglandin E3, Lactate Antiport

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

prostaglandin A2Reach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and L-lactate (cytosol to extracellular)
Transport of Prostaglandin A2, Lactate Antiport

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

prostaglandin J2Reach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and L-lactate (cytosol to extracellular)
Transport of Prostaglandin J2, Lactate Antiport

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and L-lactate (cytosol to extracellular)
Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

all-trans-4-hydroxyretinoateReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and retinoate (cytosol to extracellular)
cytochrome P450 (retinoate)

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A7 and 1 moreextracellular space, cytosolOne of 3 routes

1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholineReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine

Catalysed by PLA2G7, PRDX6, LPCAT3, LPCAT1 and 1 more

1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine

Catalysed by PLA2G7, PRDX6, LPCAT3, LPCAT1 and 1 more

1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamineReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)

Catalysed by PLA2G7, PRDX6, LPCAT3, LPCAT1 and 1 more

all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and retinoate (cytosol to extracellular)
glucuronosyltransferase (retinoate)

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A7 and 3 moreextracellular space, cytosol, endoplasmic reticulum

all-trans-18-hydroxyretinoateReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and retinoate (cytosol to extracellular)
unspecific monooxygenase (retinoate)

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A7 and 25 moreextracellular space, cytosolOne of 2 routes

2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-octadecanoyl-N-(acetyl)-sphing-4-enine

Catalysed by PLA2G7, ASAH1, PLA2G15

2-nonadioyl-sn-glycero-3-phosphocholineReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-nonadioyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine

Catalysed by PLA2G7, ASAH1, PLA2G15

1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamineReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine

Catalysed by PLA2G7, LPCAT3, MBOAT2, LPCAT1 and 1 more

acetaldehydeReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
cytochrome P450 (17alpha-hydroxypregnenolone)
cytochrome P450 (17alpha-hydroxypregnenolone)

Catalysed by PLA2G7, CYP17A1endoplasmic reticulum, cytosolOne of 3 routes

CHEBI:15345Reach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and acetoacetate (cytosol to extracellular)
Acetoacetate:CoA ligase (AMP-forming)

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A6 and 3 moreextracellular space, cytosolOne of 3 routes

acetoneReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and acetoacetate (cytosol to extracellular)
Acetoacetate carboxy-lyase (acetone-forming)

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A6 and 2 moreextracellular space, cytosol, mitochondrial matrix

acetylcholineReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
Acetyl-CoA:choline O-acetyltransferase

Catalysed by PLA2G7, ENPP2, GDPD3, GDPD1 and 1 morecytosolOne of 3 routes

propionyl-CoAReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and propanoate (cytosol to extracellular)
Propanoate:CoA ligase (AMP-forming)

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A7 and 4 moreextracellular space, cytosolOne of 3 routes

(S)-malateReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and pyruvate (cytosol to extracellular)
(S)-malate + NAD(+) = pyruvate + CO2 + NADH

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

10-formyltetrahydrofolic acidReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and formate (cytosol to extracellular)
Formate:tetrahydrofolate ligase (ADP-forming)

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A1 and 1 moreextracellular space, cytosolOne of 2 routes

betaine aldehydeReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
choline dehydrogenase (choline)

Catalysed by PLA2G7, ENPP2, GDPD3, GDPD1 and 1 morecytosolOne of 3 routes

a 1-O-alkyl-sn-glycerolReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-sn-glycero-3-phosphocholine
a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycerol + phosphocholine + H(+)

Catalysed by PLA2G7, LCAT, ENPP6

alpha-D-glucosamine 6-phosphateReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate
N-Acetyl-D-glucosamine-6-phosphate amidohydrolase

Catalysed by PLA2G7, AMDHD2, CEMP1cytosol

CHEBI:15978Reach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)
sn-Glycero-3-phosphocholine glycerophosphohydrolase

Catalysed by PLA2G7, PLA2G6, LYPLA1, LYPLA2 and 15 morecytosol

2-methyl-3-oxopropanoic acidReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and pyruvate (cytosol to extracellular)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol, mitochondrial matrix

(17R,20S)-17,20-dihydroxypregn-4-en-3-oneReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
cytochrome P450 (17alpha-hydroxyprogesterone)
(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + NADH + H(+)

Catalysed by PLA2G7, CYP17A1, AKR1C1endoplasmic reticulumOne of 2 routes

androst-4-ene-3,17-dioneReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
cytochrome P450 (17alpha-hydroxyprogesterone)
cytochrome P450 (17alpha-hydroxyprogesterone)

Catalysed by PLA2G7, CYP17A1endoplasmic reticulum, cytosolOne of 5 routes

oxaloacetateReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and pyruvate (cytosol to extracellular)
Pyruvate:carbon-dioxide ligase (ADP-forming)

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

(S)-lactateReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and pyruvate (cytosol to extracellular)
(S)-lactate + NAD(+) = pyruvate + NADH + H(+)

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A3 and 7 moreextracellular space, cytosol

2-oxobutanoateReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of 2-hydroxybutyrate and acetate (cytosol to extracellular)
2-hydroxybutyrate:NAD+ oxidoreductase

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A7 and 5 moreextracellular space, cytosolOne of 2 routes

2-oxoglutaramateReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and pyruvate (cytosol to extracellular)
L-Glutamine:pyruvate aminotransferase

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

3-fumarylpyruvateReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and pyruvate (cytosol to extracellular)
3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

ferrocytochrome cReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and L-lactate (cytosol to extracellular)
(S)-Lactate:ferricytochrome-c 2-oxidoreductase

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A3 and 4 moreextracellular space, cytosol, mitochondrial matrix

1-acyl-sn-glycerol 3-phosphateReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation

Catalysed by PLA2G7, ENPP2, GDPD3, GDPD1cytosolOne of 8 routes

3-hydroxypyruvateReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and pyruvate (cytosol to extracellular)
L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

4-methylumbelliferoneReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)
4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

Catalysed by PLA2G7, CES2, ESD, CES1

aceneuramateReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and pyruvate (cytosol to extracellular)
aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

5'-deoxyadenosineReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and pyruvate (cytosol to extracellular)
N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

Catalysed by PLA2G7, SLC16A4, SLC16A5, SLC16A3 and 4 moreextracellular space, cytosol

AH2Reach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
choline + A = betaine aldehyde + AH2

Catalysed by PLA2G7, ENPP2, GDPD3, GDPD1 and 1 more

hexadecanalReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)
hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O

Catalysed by PLA2G7, PLA2G6, LYPLA1, LYPLA2 and 17 more

all-trans-retinyl hexadecanoateReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine

Catalysed by PLA2G7, PRDX6, LPCAT3, LPCAT1 and 1 moreOne of 3 routes

a sphingomyelinReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin

Catalysed by PLA2G7, PRDX6, LPCAT3, LPCAT1 and 1 more

glycerolReach from here →

1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)
sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)

Catalysed by PLA2G7, PLA2G6, LYPLA1, LYPLA2 and 15 more