UDP-N-acetyl-alpha-D-galactosamine

1. a ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GM2 (d18:1(4E)) + UDP + H(+)
2. beta-1,3-galactosyltransferase (GM2)

Catalysed by B4GALNT1, B3GALT4cytosolOne of 4 routes

1. a ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GD2 (d18:1(4E)) + UDP + H(+)
2. Hexosaminidase A, Lysosomal

Catalysed by B4GALNT1, HEXA, HEXBlysosome

1. UDP-N-acetyl-alpha-D-galactosamine(out) + UDP-alpha-D-galactose(in) = UDP-N-acetyl-alpha-D-galactosamine(in) + UDP-alpha-D-galactose(out)
2. a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + UDP + H(+)

Catalysed by SLC35A2, B3GALT2inner side of the membrane, outer side of the membrane

1. UDP-N-acetyl-alpha-D-galactosamine(out) + UDP-alpha-D-galactose(in) = UDP-N-acetyl-alpha-D-galactosamine(in) + UDP-alpha-D-galactose(out)
2. a beta-D-glucosylceramide + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP + H(+)

Catalysed by SLC35A2, B4GALT3, B4GALT1inner side of the membrane, outer side of the membrane

1. a ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GM2 + UDP + H(+)
2. a ganglioside GM2 + H2O = a ganglioside GM3 + N-acetyl-beta-D-galactosamine

Catalysed by B4GALNT1, HEXA, HEXB

1. a ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GM2 + UDP + H(+)
2. a ganglioside GM2 + UDP-alpha-D-galactose = a ganglioside GM1 + UDP + H(+)

Catalysed by B4GALNT1, B3GALT4One of 2 routes

1. UDP-N-acetyl-alpha-D-galactosamine(out) + UDP-alpha-D-galactose(in) = UDP-N-acetyl-alpha-D-galactosamine(in) + UDP-alpha-D-galactose(out)
2. N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose = N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP + H(+)

Catalysed by SLC35A2, UGT8inner side of the membrane, outer side of the membrane

1. UDP-N-acetyl-alpha-D-galactosamine(out) + UDP-alpha-D-galactose(in) = UDP-N-acetyl-alpha-D-galactosamine(in) + UDP-alpha-D-galactose(out)
2. N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose = N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP + H(+)

Catalysed by SLC35A2, UGT8inner side of the membrane, outer side of the membrane

1. a ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GD2 (d18:1(4E)) + UDP + H(+)
2. beta-1,3-galactosyltransferase (GD2)

Catalysed by B4GALNT1, B3GALT4cytosolOne of 4 routes

1. UDP-N-acetyl-alpha-D-galactosamine(out) + UDP-alpha-D-galactose(in) = UDP-N-acetyl-alpha-D-galactosamine(in) + UDP-alpha-D-galactose(out)
2. a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose = a globoside Gb3Cer + UDP + H(+)

Catalysed by SLC35A2, A4GALTinner side of the membrane, outer side of the membrane

1. UDP-N-acetyl-alpha-D-galactosamine(out) + UDP-alpha-D-galactose(in) = UDP-N-acetyl-alpha-D-galactosamine(in) + UDP-alpha-D-galactose(out)
2. a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose = a neolactoside nLc6Cer + UDP + H(+)

Catalysed by SLC35A2, B4GALT3, B4GALT1inner side of the membrane, outer side of the membrane

1. a ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GD2 (d18:1(4E)) + UDP + H(+)
2. Hexosaminidase A, Lysosomal
3. solute carrier (acetyl-CoA)

Catalysed by B4GALNT1, HEXA, HEXB, SLC33A1lysosome, cytosolOne of 2 routes

1. UDP-N-acetyl-alpha-D-galactosamine(out) + UDP-alpha-D-galactose(in) = UDP-N-acetyl-alpha-D-galactosamine(in) + UDP-alpha-D-galactose(out)
2. an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+)