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Proteins/UNIPROT:O95395
Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Also has I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development..
Function from UniProtKB (O95395), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
44 statements
44 statements · 6 reference databases · Subject: GCNT3 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea
8 reactions
MAM01608g+CHEBI:16264MAM01609g+proton+UDP
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.148Golgi apparatus
Human-GEM MAR07175CC BY 4.0Reference data
MAM03000g+CHEBI:16264MAM01871g+proton+UDP
5 names
Resolves to: GCNT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.102Golgi apparatus
Human-GEM MAR07180CC BY 4.0Reference data
MAM02960g+CHEBI:16264MAM01607g+proton+UDP
Catalysed by GCNT3 or GCNT4 or GCNT1
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.102Golgi apparatus
Human-GEM MAR07440CC BY 4.0Reference data
a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative+UDP-N-acetyl-alpha-D-glucosaminea beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-GlcNAc derivative+UDP+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:54820CC BY 4.0Reference data
3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]+UDP-N-acetyl-alpha-D-glucosamine3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]+UDP+hydron
Catalysed by GCNT3
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:56188CC BY 4.0Reference data
a 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]+UDP-N-acetyl-alpha-D-glucosamine3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]+UDP+hydron
Catalysed by GCNT3
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:56192CC BY 4.0Reference data
a 3-O-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]+UDP-N-acetyl-alpha-D-glucosamine3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein]+UDP+hydron
Catalysed by GCNT3 or GCNT1 or GCNT4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:56212CC BY 4.0Reference data
a 3-O-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]+UDP-N-acetyl-alpha-D-glucosaminea 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein]+UDP+hydron
Catalysed by GCNT3 or GCNT1 or GCNT4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:56216CC BY 4.0Reference data