Compound

hexanoyl-CoA

An acyl-CoA(4−) oxoanion arising from deprotonation of the phosphate and diphosphate OH groups of hexanoyl-CoA; major species at pH 7.3.

Definition from ChEBI (CHEBI:62620), read 2026-09-23. CC BY 4.0.

CHEBI:62620ChEBI

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Structure

2D depiction

No three-dimensional record for this entry.

Class: Organic compound, anion
Formula: C27H42N7O17P3S
Mass: 861.654 g/mol
Charge: -4
InChIKey: OEXFMSFODMQEPE-HDRQGHTBSA-J
SMILES: CCCCCC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-]
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

17 entities

17 entities reached.

0 reported hops17 assembled from the scaffold

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What the reference databases state

Statements

28 statements

28 statements · 1 reference database · Subject: hexanoyl-CoA · Sources: Rhea

Order

(2E)-hexenoyl-CoA is converted to hexanoyl-CoACompoundRhea RHEA:52576Inferred only
hexanoyl-CoA is converted to (2E)-hexenoyl-CoACompoundRhea RHEA:40311Inferred only
hexanoyl-CoA is converted to (2E)-hexenoyl-CoACompoundRhea RHEA:52576Inferred only
(2E)-hexenoyl-CoA is converted to hexanoyl-CoACompoundRhea RHEA:31207Inferred only
(2E)-hexenoyl-CoA is converted to hexanoyl-CoACompoundRhea RHEA:44956Inferred only
hexanoyl-CoA is converted to (2E)-hexenoyl-CoACompoundRhea RHEA:31207Inferred only
hexanoyl-CoA is converted to 2-hydroxyhexanoyl-CoACompoundRhea RHEA:55172Inferred only
3-oxooctanoyl-CoA is converted to hexanoyl-CoACompoundRhea RHEA:31203Inferred only
hexanoate is converted to hexanoyl-CoACompoundRhea RHEA:43740Inferred only
hexanoyl-CoA is converted to hexanoateCompoundRhea RHEA:40115Inferred only
hexanoyl-CoA is converted to hexanoyl-4'-phosphopantetheineCompoundRhea RHEA:49980Inferred only
hexanoyl-CoA is a substrate of ACAA2ProteinRhea RHEA:40115Inferred only

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hexanoyl-CoA is a substrate of ACADLProteinRhea RHEA:43464Inferred only
hexanoyl-CoA is a substrate of ACADMProteinRhea RHEA:43464Inferred only
hexanoyl-CoA is a substrate of ACADSProteinRhea RHEA:43464Inferred only
hexanoyl-CoA is a substrate of ACADSBProteinRhea RHEA:43464Inferred only
hexanoyl-CoA is a substrate of ACOT12ProteinRhea RHEA:40115Inferred only
hexanoyl-CoA is a substrate of ACOT13ProteinRhea RHEA:40115Inferred only
hexanoyl-CoA is a substrate of ACOT8ProteinRhea RHEA:40115Inferred only
hexanoyl-CoA is a substrate of ACOX1ProteinRhea RHEA:40311Inferred only
hexanoyl-CoA is a substrate of CRATProteinRhea RHEA:44972Inferred only
hexanoyl-CoA is a substrate of IVDProteinRhea RHEA:43464Inferred only
hexanoyl-CoA is a substrate of LPCAT1ProteinRhea RHEA:37855Inferred only
hexanoyl-CoA is a substrate of MBOAT4ProteinRhea RHEA:68284Inferred only
hexanoyl-CoA is a substrate of NUDT19ProteinRhea RHEA:49980Inferred only
hexanoyl-CoA is a substrate of NUDT7ProteinRhea RHEA:49980Inferred only
hexanoyl-CoA is a substrate of NUDT8ProteinRhea RHEA:49980Inferred only
hexanoyl-CoA is a substrate of PHYHProteinRhea RHEA:55172Inferred only

Reactions

22 reactions

hexanoyl-CoA+acetyl-CoA3-oxooctanoyl-CoA+coenzyme A(4-)
Catalysed by ACAA1 or SCP2 or HADHB
Reaction pageRight to leftBalanced
Rhea RHEA:31203CC BY 4.0Reference data
hexanoyl-CoA+FAD(3-)+hydron(2E)-hexenoyl-CoA+FADH2(2-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:31207CC BY 4.0Reference data
hexanoyl-CoA+3malonyl-CoA+3hydronCHEBI:66957+3carbon dioxide+3coenzyme A(4-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:34119CC BY 4.0Reference data
hexanoyl-CoA+1-hexadecanoyl-sn-glycero-3-phosphocholine1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine+coenzyme A(4-)
Catalysed by LPCAT1
Reaction pageLeft to rightBalanced
Rhea RHEA:37855CC BY 4.0Reference data
hexanoyl-CoA+waterhexanoate+coenzyme A(4-)+hydron
Catalysed by ACOT8 or ACAA2 or ACOT12 or ACOT13
Reaction pageLeft to rightBalanced
Rhea RHEA:40115CC BY 4.0Reference data
hexanoyl-CoA+dioxygen(2E)-hexenoyl-CoA+hydrogen peroxide
Catalysed by ACOX1
Reaction pageLeft to rightBalanced
Rhea RHEA:40311CC BY 4.0Reference data
hexanoyl-CoA+malonyl-[ACP]+hydron3-oxooctanoyl-[ACP]+carbon dioxide+coenzyme A(4-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:42256CC BY 4.0Reference data
hexanoyl-CoA+2malonyl-CoA+2hydronCHEBI:66958+2carbon dioxide+3coenzyme A(4-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:43452CC BY 4.0Reference data
hexanoyl-CoA+oxidized [electron-transfer flavoprotein]+hydron(2E)-hexenoyl-CoA+reduced [electron-transfer flavoprotein]
Catalysed by ACADM or ACADS or IVD or ACADL or ACADSB
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:43464CC BY 4.0Reference data
hexanoate+ATP(4-)+coenzyme A(4-)hexanoyl-CoA+AMP+diphosphate(3-)
Catalysed by ACSM4 or ACSM1 or ACSM2A or ACSM2B
Reaction pageLeft to rightBalanced
Rhea RHEA:43740CC BY 4.0Reference data
(2E)-hexenoyl-CoA+NADPH(4-)+hydronhexanoyl-CoA+NADP(3-)
Catalysed by PECR
Reaction pageLeft to rightBalanced
Rhea RHEA:44956CC BY 4.0Reference data
hexanoyl-CoA+(R)-carnitineO-hexanoyl-(R)-carnitine+coenzyme A(4-)
Catalysed by CRAT
Reaction pageLeft to rightBalanced
Rhea RHEA:44972CC BY 4.0Reference data

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Other names

4 names

Resolves to: hexanoyl-CoA

Also called: caproyl-CoA(4-)caproyl-CoA(4−)hexanoyl-coenzyme A
Systematic name: 3'-phosphonatoadenosine 5'-(3-{(3R)-3-hydroxy-4-[(3-{[2-(hexanoylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-2,2-dimethyl-4-oxobutyl} diphosphate)