a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)

Three steps

• N-acetylcadaverineReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + UDP + H(+)
  2. phosphatidylinositol glycan anchor biosynthesis class L
  3. N-acetylcadaverine + H2O = cadaverine + acetate

  Catalysed by PIGA, PIGL, HDAC10endoplasmic reticulum

• cholesterol sulfateReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. cholesterol + 3'-phosphoadenylyl sulfate = cholesterol sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 3 moreinner side of the membrane, outer side of the membrane

• acetoacetateReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + UDP + H(+)
  2. phosphatidylinositol glycan anchor biosynthesis class L
  3. transport of acetate and acetoacetate (cytosol to extracellular)

  Catalysed by PIGA, PIGL, SLC16A4, SLC16A5 and 3 moreendoplasmic reticulum, extracellular space, cytosolOne of 2 routes

• (11Z,14Z,17Z-eicosatrienoyl)-cholesterolReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. 1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 moreinner side of the membrane, outer side of the membrane

• an N-acyl-sphinga-4E,14Z-dienineReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 7 more

• a phenyl acetateReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + UDP + H(+)
  2. phosphatidylinositol glycan anchor biosynthesis class L
  3. a phenyl acetate + H2O = a phenol + acetate + H(+)

  Catalysed by PIGA, PIGL, PON1, PON2 and 1 moreendoplasmic reticulum

• a 3-hydroxyacyl derivative of bacterial toxinReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)
  2. a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = a 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)
  3. a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = a 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)

  Catalysed by DDHD1, AOAH

• a 2-acyl-6-alpha-D-glucosaminyl-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + UDP + H(+)
  2. phosphatidylinositol glycan anchor biosynthesis class L
  3. a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + a fatty acyl-CoA = a 2-acyl-6-alpha-D-glucosaminyl-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + CoA

  Catalysed by PIGA, PIGL, PIGWendoplasmic reticulumOne of 2 routes

• a 2-acyl-6-[alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 2-acyl-6-[alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-6-[alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycerol

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 7 more

• a 2-acyl-6-[2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-6-[2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycerol

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 7 more

• a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycerol

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 7 more

• a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-6-phosphoethanolamine-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-6-phosphoethanolamine-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycerol

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 7 more

• an N-(fatty acyl)-glycineReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)
  2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by DDHD1, ACSL3, GLYATL2

• cholesteryl (7Z)-octadecenoateReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. (7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA

  Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 moreinner side of the membrane, outer side of the membrane

• (7Z)-octadecenoyl-CoAReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 12 morecytosolOne of 3 routes

• CHEBI:15345Reach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 10 morecytosolOne of 2 routes

• cholineReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)

  Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 4 moreinner side of the membrane, outer side of the membraneOne of 9 routes

• acetylpyruvateReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + UDP + H(+)
  2. phosphatidylinositol glycan anchor biosynthesis class L
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by PIGA, PIGL, FAHD1endoplasmic reticulum

• pyruvateReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + UDP + H(+)
  2. phosphatidylinositol glycan anchor biosynthesis class L
  3. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by PIGA, PIGL, SLC16A4, SLC16A5 and 3 moreendoplasmic reticulum, extracellular space, cytosolOne of 2 routes

• all-trans-retinoic acidReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + UDP + H(+)
  2. phosphatidylinositol glycan anchor biosynthesis class L
  3. transport of acetate and retinoate (cytosol to extracellular)

  Catalysed by PIGA, PIGL, SLC16A4, SLC16A5 and 1 moreendoplasmic reticulum, extracellular space, cytosolOne of 2 routes

• CHEBI:15380Reach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 11 morecytosol, mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 12 morecytosol, mitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Production of Tiglylcarnitine

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 11 morecytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 12 morecytosol, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 10 morecytosol, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 12 morecytosol, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 17 morecytosolOne of 11 routes

• CHEBI:15519Reach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 12 morecytosol, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 17 morecytosolOne of 11 routes

• oleoyl-CoAReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 12 morecytosolOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 9 morecytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 12 morecytosolOne of 43 routes

• a 1-hexadecanoyl-2-acylglycerolReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)
  2. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + a 2-acylglycerol + H(+)
  3. a 2-acylglycerol + hexadecanoyl-CoA = a 1-hexadecanoyl-2-acylglycerol + CoA

  Catalysed by DDHD1, GDPD2, LPGAT1

• CHEBI:15650Reach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 41 morecytosolOne of 2 routes

• CHEBI:15727Reach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 10 morecytosol

• CHEBI:15746Reach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 11 morecytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 5 moreextracellular spaceOne of 12 routes

• keto-D-fructose 6-phosphateReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. inositol-3-phosphate synthase (inositol-1-phosphate)
  3. D-glucose-6-phosphate aldose-ketose-isomerase

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 6 morecytosol

• 11-cis-retinolReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)
  2. an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)
  3. all-trans-retinyl ester acylhydrolase, 11-cis-retinol forming

  Catalysed by DDHD1, RPE65cytosolOne of 3 routes

• oxaloacetateReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 10 morecytosol

• N(2)-acetyl-L-ornithineReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + UDP + H(+)
  2. phosphatidylinositol glycan anchor biosynthesis class L
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by PIGA, PIGL, ACY1endoplasmic reticulum, cytosol

• CHEBI:16566Reach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
  3. N-acylsphingosine amidohydrolase

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 11 morecytosol

• pregnenoloneReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. 6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O

  Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 moreinner side of the membrane, outer side of the membrane

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)
  2. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  3. ATP:acylglycerol 3-phosphotransferase

  Catalysed by DDHD1, LIPE, AGKcytosolOne of 6 routes

• a cholesterol esterReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. an acyl-CoA + cholesterol = a cholesterol ester + CoA

  Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 3 moreinner side of the membrane, outer side of the membraneOne of 3 routes

• (R)-3-hydroxybutyric acidReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + UDP + H(+)
  2. phosphatidylinositol glycan anchor biosynthesis class L
  3. transport of (R)-3-hydroxybutanoate and acetate (cytosol to extracellular)

  Catalysed by PIGA, PIGL, SLC16A4, SLC16A5 and 2 moreendoplasmic reticulum, extracellular space, cytosolOne of 2 routes

• 17alpha-hydroxyprogesteroneReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + UDP + H(+)
  2. phosphatidylinositol glycan anchor biosynthesis class L
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by PIGA, PIGL, CYP17A1endoplasmic reticulum

• anilineReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 11 morecytosol

• CHEBI:17312Reach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 9 morecytosolOne of 2 routes

• all-trans-retinolReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)
  2. an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)
  3. carboxylesterase (retinyl-ester)

  Catalysed by DDHD1, RPE65, CES2, RBP4 and 18 morecytosolOne of 2 routes