leukotriene A4

Three steps

• N-hexadecanoylglycineReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

  Catalysed by LTC4S, GLYATL3cytosol

• N-dodecanoylglycineReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

  Catalysed by LTC4S, GLYATL2cytosol

• N-decanoylglycineReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by LTC4S, GLYATL2cytosol

• N-octanoylglycineReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by LTC4S, GLYATL2cytosol

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by LTC4S, GARTcytosol

• L-cystine-bis-glycineReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by LTC4S, DPEP1, DPEP2cytosolOne of 2 routes

• glycyldehydrophenylalanineReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by LTC4S, DPEP1cytosol

• S-adenosylglutathioneReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. apo-[alkylcobalamin reductase] + adenosylcob(III)alamin + glutathione = S-adenosylglutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

  Catalysed by LTC4S, MGST3, GSTM4, MGST2 and 1 morecytosol

• 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of leukotriene A4 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. arachidonate to 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate conversion

  Catalysed by SLCO1B1extracellular space, cytosolOne of 2 routes

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serineReach from here →
  1. transport of leukotriene A4 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine

  Catalysed by SLCO1B1, FAAH, PM20D1extracellular space, cytosol

• an N-(fatty acyl)-glycineReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by LTC4S, GLYATL2cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by LTC4S, GLYATL2cytosol

• (15S)-15-hydroperoxy-prostaglandin E2Reach from here →
  1. transport of leukotriene A4 (cytosol to extracellular)
  2. transport of prostaglandin G2 (cytosol to extracellular)
  3. prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2

  Catalysed by SLCO1B1, PTGESextracellular space, cytosol

• cholineReach from here →
  1. transport of leukotriene A4 (cytosol to extracellular)
  2. transport of acetylcholine (cytosol to extracellular)
  3. Acetylcholine aectylhydrolase

  Catalysed by SLCO1B1, SLCO1B3, BCHE, ACHEextracellular space, cytosolOne of 5 routes

• pyruvateReach from here →
  1. transport of GSH and leukotriene A4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by SLCO2A1, CTHextracellular space, cytosolOne of 2 routes

• arachidonoyl-CoAReach from here →
  1. transport of leukotriene A4 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by SLCO1B1, SLC27A2, ACSL4, ACSL3 and 5 moreextracellular space, cytosolOne of 3 routes

• CHEBI:15519Reach from here →
  1. transport of leukotriene A4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (cholate)
  3. Cholate:CoA ligase (AMP-forming)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLC27A2 and 1 moreextracellular space, cytosol, endoplasmic reticulum

• CHEBI:15570Reach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by LTC4S, SLC3A2, SLC7A10cytosol, extracellular spaceOne of 2 routes

• L-leucineReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. transport of glycine and leucine (cytosol to extracellular)

  Catalysed by LTC4S, SLC7A5cytosol, extracellular spaceOne of 8 routes

• CHEBI:15611Reach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by LTC4S, GNMTcytosol

• 12(S)-HPETEReach from here →
  1. transport of leukotriene A4 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. arachidonate:oxygen 12-oxidoreductase

  Catalysed by SLCO1B1, ALOX12extracellular space, cytosolOne of 4 routes

• 15(S)-HPETEReach from here →
  1. transport of leukotriene A4 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. arachidonate:oxygen 15-oxidoreductase

  Catalysed by SLCO1B1, ALOX15B, ALOX15extracellular space, cytosolOne of 6 routes

• 5(S)-HPETEReach from here →
  1. transport of leukotriene A4 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. Arachidonate:oxygen 5-oxidoreductase

  Catalysed by SLCO1B1, ALOX5extracellular space, cytosol

• CHEBI:15699Reach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. transport of glycine and homoserine (cytosol to extracellular)

  Catalysed by LTC4S, SLC7A5cytosol, extracellular spaceOne of 7 routes

• formateReach from here →
  1. transport of GSH and leukotriene A4 (cytosol to extracellular)
  2. alcohol dehydrogenase (formaldehyde)
  3. S-formylglutathione + H2O = formate + glutathione + H(+)

  Catalysed by SLCO2A1, ADH1C, ADH1A, ADH5 and 4 moreextracellular space, cytosol

• CHEBI:15971Reach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. transport of glycine and histidine (cytosol to extracellular)

  Catalysed by LTC4S, SLC7A6cytosol, extracellular spaceOne of 4 routes

• (R)-lactateReach from here →
  1. transport of GSH and leukotriene A4 (cytosol to extracellular)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)

  Catalysed by SLCO2A1, GLO1, GLOD4, HAGHextracellular space, cytosol

• a halide anionReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by LTC4S, MGST3, GSTM4, MGST2 and 21 morecytosol

• octan-1-olReach from here →
  1. transport of leukotriene A4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)
  3. octyl beta-D-glucose + chenodeoxycholate = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, GBA2extracellular space, cytosol

• sulfateReach from here →
  1. transport of leukotriene A4 (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. steroid sulfatase (sulfoglycolithocholate)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, STSextracellular space, cytosolOne of 7 routes

• L-cystineReach from here →
  1. transport of GSH and leukotriene A4 (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase
  3. cystine to cysteine conversion

  Catalysed by SLCO2A1, GPX5, GPX1, GPX2 and 6 moreextracellular space, cytosolOne of 5 routes

• L-citrullineReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by LTC4S, SLC7A9, SLC3A1, SLC7A6cytosol, extracellular spaceOne of 3 routes

• iodideReach from here →
  1. transport of leukotriene A4 (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DIO1 and 1 moreextracellular space, cytosolOne of 9 routes

• L-valineReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. transport of glycine and valine (cytosol to extracellular)

  Catalysed by LTC4S, SLC7A5cytosol, extracellular spaceOne of 7 routes

• L-arginineReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by LTC4S, SLC7A6cytosol, extracellular spaceOne of 7 routes

• CHEBI:16523Reach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by LTC4S, SLC3A2, SLC7A10cytosol, extracellular spaceOne of 2 routes

• protein polypeptide chainReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. PROTEIN_BS

  Catalysed by LTC4ScytosolOne of 2 routes

• (S)-lactateReach from here →
  1. transport of leukotriene A4 (cytosol to extracellular)
  2. transport of prostaglandin E2 (cytosol to extracellular)
  3. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 14 routes

• taurochenodeoxycholate 3-sulfateReach from here →
  1. transport of leukotriene A4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)
  3. taurochenodeoxycholate + 3'-phosphoadenylyl sulfate = taurochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLC7A9, SLCO1B3 and 1 moreextracellular space, cytosol

• dopamine quinoneReach from here →
  1. transport of leukotriene A4 (cytosol to extracellular)
  2. transport of dopamine (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, MPOextracellular space, cytosol, lysosomeOne of 4 routes

• formaldehydeReach from here →
  1. transport of GSH and leukotriene A4 (cytosol to extracellular)
  2. alcohol dehydrogenase (formaldehyde)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by SLCO2A1, ADH1C, ADH1A, ADH5 and 3 moreextracellular space, cytosol

• CHEBI:16857Reach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by LTC4S, SLC3A2, SLC7A5, SLC7A10cytosol, extracellular spaceOne of 8 routes

• glyoxylic acidReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by LTC4S, DAOcytosol, peroxisome

• (R)-lactaldehydeReach from here →
  1. transport of GSH and leukotriene A4 (cytosol to extracellular)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)

  Catalysed by SLCO2A1, GLO1, GLOD4, ADH1C and 6 moreextracellular space, cytosol

• L-isoleucineReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by LTC4S, SLC7A5cytosol, extracellular spaceOne of 8 routes

• CHEBI:17203Reach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. transport of glycine and proline (cytosol to extracellular)

  Catalysed by LTC4S, SLC7A5, SLC7A6cytosol, extracellular spaceOne of 5 routes

• dehydroascorbic acidReach from here →
  1. transport of leukotriene A4 (cytosol to extracellular)
  2. transport of dopamine (cytosol to extracellular)
  3. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DBHextracellular space, cytosolOne of 19 routes

• estroneReach from here →
  1. transport of leukotriene A4 (cytosol to extracellular)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by SLCO1B1, STSextracellular space, cytosolOne of 3 routes

• propanoateReach from here →
  1. transport of leukotriene A4 (cytosol to extracellular)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)

  Catalysed by SLCO1B1, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• sulfiteReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by LTC4S, MGST3, GSTM4, MGST2 and 1 morecytosolOne of 4 routes