(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

128 compounds within 3 steps: 6 in 1, 13 in 2, 109 in 3

Three steps

bilirubin IXalphaReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of leukotriene A4 (cytosol to extracellular)
3. transport of bilirubin (cytosol to extracellular)
Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes
taurolithocholateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of leukotriene A4 (cytosol to extracellular)
3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes
CHEBI:17208Reach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of GSH and leukotriene A4 (cytosol to extracellular)
3. glutathione:dehydroascorbate oxidoreductase
Catalysed by ALOX5, SLCO2A1extracellular space, cytosol
homocysteineReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of GSH and leukotriene A4 (cytosol to extracellular)
3. Formation of Homocystine
Catalysed by ALOX5, SLCO2A1extracellular space, cytosol
all-trans-retinolReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
Catalysed by PTGES, MGST3, GPX1, GPX2 and 4 more
sulfiteReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
Catalysed by PTGES, MGST3, GPX1, GPX2 and 4 moreOne of 6 routes
AH2Reach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
3. A + NADH + H(+) = AH2 + NAD(+)
Catalysed by PTGES, MGST3, GPX1, GPX2 and 5 moreOne of 19 routes
L-cysteineReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of GSH and leukotriene A4 (cytosol to extracellular)
3. cystine to cysteine conversion
Catalysed by ALOX5, SLCO2A1extracellular space, cytosolOne of 5 routes
urateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. urate(out) + glutathione(in) = urate(in) + glutathione(out)
Catalysed by PTGES, MGST3, GPX1, GPX2 and 4 moreinner side of the membrane, outer side of the membrane
methylarsonous acidReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
Catalysed by PTGES, MGST3, GPX1, GPX2 and 5 moreOne of 2 routes
fumaric acidReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. transport of fumarate and thiosulfate (cytosol to mitochondria)
Catalysed by PTGES, MGST3, GPX1, GPX2 and 4 moremitochondrial matrix, cytosolOne of 2 routes
thiocyanateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. thiosulfate:cyanide sulfurtranserase
Catalysed by PTGES, MGST3, GPX1, GPX2 and 5 moremitochondrial matrixOne of 2 routes
arsenic triglutathioneReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)
Catalysed by PTGES, MGST3, GPX1, GPX2 and 4 moreOne of 3 routes
15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione
Catalysed by PTGES, MGST3, GPX1, GPX2 and 3 more
(5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
Catalysed by PTGES, MGST3, GPX1, GPX2 and 3 more
(12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
Catalysed by PTGES, MGST3, GPX1, GPX2 and 3 more
(15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O
Catalysed by PTGES, MGST3, GPX1, GPX2 and 3 more
(17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O
Catalysed by PTGES, MGST3, GPX1, GPX2 and 3 more
a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O
Catalysed by PTGES, MGST3, GPX1, GPX2 and 3 more
3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal
Catalysed by PTGES, MGST3, GPX1, GPX2 and 4 more
a quinolReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
Catalysed by PTGES, MGST3, GPX1, GPX2 and 4 more
5(S)-HETEReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of GSH and leukotriene A4 (cytosol to extracellular)
3. Glutathione: 5-HPETE oxidoreductase
Catalysed by ALOX5, SLCO2A1, GPX5, GPX1 and 7 moreextracellular space, cytosolOne of 2 routes
CHEBI:28666Reach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. leukotriene C4 synthase (GSH)
3. gamma-glutamyltransferase (leukotriene C4)
Catalysed by ALOX5, LTC4S, GGT1, GGT5 and 4 morecytosol, extracellular spaceOne of 7 routes
3-disulfanyl-L-alanineReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. cystine to cysteine conversion
3. L-cystine thiocysteine-lyase (deaminating
Catalysed by PTGES, MGST3, GPX1, GPX2 and 3 morecytosol
L-ascorbic acidReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
Catalysed by PTGES, MGST3, GPX1, GPX2 and 6 more
glycocholateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of leukotriene A4 (cytosol to extracellular)
3. solute carrier organic anion transporter (glycocholate)
Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 5 routes
cholateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of leukotriene A4 (cytosol to extracellular)
3. solute carrier organic anion transporter (cholate)
Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 5 routes
hydrogen sulfideReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
Catalysed by PTGES, MGST3, GPX1, GPX2 and 4 moreOne of 3 routes
L-aspartateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. cystine to cysteine conversion
3. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)
Catalysed by PTGES, MGST3, GPX1, GPX2 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
an alcoholReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
Catalysed by PTGES, MGST3, GPX1, GPX2 and 5 more
(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of leukotriene A4 (cytosol to extracellular)
3. transport of arachidonate (cytosol to extracellular)
Catalysed by ALOX5, SLCO1B1extracellular space, cytosolOne of 4 routes
serotoninReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of leukotriene A4 (cytosol to extracellular)
3. transport of serotonin (cytosol to extracellular)
Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes
chenodeoxycholateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of leukotriene A4 (cytosol to extracellular)
3. solute carrier organic anion transporter (chenodiol)
Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes
glycochenodeoxycholateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
Catalysed by PTGES, MGST3, GPX1, GPX2 and 4 moreinner side of the membrane, outer side of the membrane
taurocholateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of leukotriene A4 (cytosol to extracellular)
3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)
Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 5 routes
glycolithocholic acidReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of leukotriene A4 (cytosol to extracellular)
3. transport of glycolithocholate (cytosol to extracellular)
Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes
tert-butanolReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O
Catalysed by PTGES, MGST3, GPX1, GPX2 and 5 more
gamma-Glu-AlaReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of GSH and leukotriene A4 (cytosol to extracellular)
3. gamma-glutamyltransferase (alanine)
Catalysed by ALOX5, SLCO2A1, GGT1, GGT5 and 4 moreextracellular space, cytosol
3,3',5-triiodo-L-thyronineReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of leukotriene A4 (cytosol to extracellular)
3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes
glycineReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. leukotriene C4 synthase (GSH)
3. leukotriene C4 hydrolysis
Catalysed by ALOX5, LTC4ScytosolOne of 2 routes
prostaglandin E1Reach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of leukotriene A4 (cytosol to extracellular)
3. transport of prostaglandin E1 (cytosol to extracellular)
Catalysed by ALOX5, SLCO1B1extracellular space, cytosolOne of 4 routes
prostaglandin I2Reach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of leukotriene A4 (cytosol to extracellular)
3. transport of prostaglandin I2 (cytosol to extracellular)
Catalysed by ALOX5, SLCO1B1extracellular space, cytosolOne of 4 routes
prostaglandin F2alphaReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of leukotriene A4 (cytosol to extracellular)
3. transport of prostaglandin F2alpha (cytosol to extracellular)
Catalysed by ALOX5, SLCO1B1extracellular space, cytosolOne of 4 routes
prostaglandin H2Reach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of leukotriene A4 (cytosol to extracellular)
3. transport of prostaglandin H2 (cytosol to extracellular)
Catalysed by ALOX5, SLCO1B1extracellular space, cytosolOne of 4 routes
prostaglandin D2Reach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of leukotriene A4 (cytosol to extracellular)
3. transport of prostaglandin D2 (cytosol to extracellular)
Catalysed by ALOX5, SLCO1B1extracellular space, cytosolOne of 4 routes
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of GSH and leukotriene A4 (cytosol to extracellular)
3. Glutathione: 15-HPETE oxidoreductase
Catalysed by ALOX5, SLCO2A1, GPX5, GPX1 and 7 moreextracellular space, cytosolOne of 3 routes
7,8-dihydrofolateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
Catalysed by PTGES, MGST3, GPX1, GPX2 and 4 more
(R)-S-lactoylglutathioneReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of GSH and leukotriene A4 (cytosol to extracellular)
3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
Catalysed by ALOX5, SLCO2A1, GLO1, GLOD4extracellular space, cytosolOne of 3 routes
S-formylglutathioneReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of GSH and leukotriene A4 (cytosol to extracellular)
3. alcohol dehydrogenase (formaldehyde)
Catalysed by ALOX5, SLCO2A1, ADH1C, ADH1A and 4 moreextracellular space, cytosolOne of 2 routes
dehydroepiandrosterone 3-sulfateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of leukotriene A4 (cytosol to extracellular)
3. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
Catalysed by ALOX5, SLCO1B1extracellular space, cytosolOne of 2 routes