CHEBI:240943

Three steps

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by GLYAT, GLYATL2, GLYATL1, HADHA and 2 moremitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by GLYAT, GLYATL2, GLYATL1, ECHS1 and 2 moremitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by GLYAT, GLYATL2, GLYATL1, ECHS1 and 2 moremitochondrial matrixOne of 2 routes

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 1 moremitochondrial matrix

• glycoursodeoxycholate 3-sulfateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine to glycoursodeoxycholate conversion
  3. glycoursodeoxycholate + 3'-phosphoadenylyl sulfate = glycoursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SULT2A1mitochondrial matrix, cytosol

• glycochenodeoxycholate 3-sulfateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)
  3. glycochenodeoxycholate + 3'-phosphoadenylyl sulfate = glycochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by GLYAT, GLYATL2, GLYATL1, BAAT and 1 moremitochondrial matrix

• deoxycholateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. Glycodeoxycholate amidohydrolase
  3. Glycodeoxycholate amidohydrolase

  Catalysed by GLYAT, GLYATL2, GLYATL1mitochondrial matrix, cytosol

• a quinolReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 1 moremitochondrial matrix

• alpha-linolenic acidReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC6A5, SLC6A14extracellular space, cytosol, endoplasmic reticulum

• folic acidReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Folate Transport by Oats

  Catalysed by SLC6A5, SLC26A6, SLC22A8, SLC22A7extracellular space, cytosolOne of 2 routes

• CHEBI:27540Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by GLYAT, GLYATL2, GLYATL1, ACSM4 and 5 moremitochondrial matrix, cytosolOne of 6 routes

• elaidic acidReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes

• 5-hydroxytryptophanReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 5(S)-HETEReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 9 moremitochondrial matrix, cytosolOne of 2 routes

• CHEBI:28701Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by GLYAT, GLYATL2, GLYATL1, ACAA1 and 2 moremitochondrial matrix, peroxisomeOne of 7 routes

• pyridoxine 5'-phosphateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of alanine and glycine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 3 moremitochondrial matrix, extracellular space, cytosol

• N-acetyl-L-cysteineReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 3 moremitochondrial matrix, extracellular space, cytosol

• a dicarboxylateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. Hippurate (Benzoylglycinate) Formation
  3. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC22A6 and 1 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 4 routes

• L-ascorbic acidReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 3 moremitochondrial matrix

• K(+)Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 3 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• Ca(2+)Reach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride (cytosol to extracellular)
  3. transport of Ca2+ and K+ (cytosol to extracellular)

  Catalysed by SLC6A5, SLC12A2, SLC12A1, SLC24A1 and 4 moreextracellular space, cytosol

• Cys-tRNA(Cys)Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 3 moremitochondrial matrix, extracellular space, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 2 moremitochondrial matrix, extracellular space, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and isoleucine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosol

• isocyanateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of citrulline and glycine (cytosol to extracellular)
  3. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A9 and 3 moremitochondrial matrix, extracellular space, cytosol

• hypoioditeReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and iodide (cytosol to extracellular)
  3. iodide + H2O2 = hypoiodite + H2O

  Catalysed by SLC6A5, SLC26A4, MPO, LPOextracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of asparagine and glycine (cytosol to extracellular)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, NARS1mitochondrial matrix, extracellular space, cytosol

• phosphocholineReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and choline (cytosol to extracellular)
  3. phosphocholine + H2O = choline + phosphate

  Catalysed by SLC6A5, SLC5A7, PHOSPHO1extracellular space, cytosolOne of 2 routes

• cholateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 2 moremitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• glycolateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine:oxygen oxidoreductase (deaminating)
  3. glycolate:NADP+ oxidoreductase

  Catalysed by GLYAT, GLYATL2, GLYATL1, DAO and 1 moremitochondrial matrix, peroxisome, cytosolOne of 3 routes

• hydrogen sulfideReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• D-aspartateReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by SLC6A5, SLC26A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-aspartateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of alanine and glycine (cytosol to extracellular)
  3. oxaloacetate + L-alanine = L-aspartate + pyruvate

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 25 routes

• acetateReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of acetate and formate (cytosol to extracellular)

  Catalysed by SLC6A5, SLC26A4, SLC16A4, SLC16A5 and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:30249Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 3 moremitochondrial matrix, extracellular space, cytosol

• oxalateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. glyoxylate + O2 + H2O = oxalate + H2O2 + H(+)

  Catalysed by GLYAT, GLYATL2, GLYATL1, AADAT and 1 moremitochondrial matrixOne of 3 routes

• propionic acidReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of formate and propanoate (cytosol to extracellular)

  Catalysed by SLC6A5, SLC26A4, SLC16A4, SLC16A5 and 1 moreextracellular space, cytosolOne of 2 routes

• citric acidReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC6A5, SLC26A6, SLC25A1extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• butyric acidReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of butyrate and formate (cytosol to extracellular)

  Catalysed by SLC6A5, SLC26A4, SLC16A4, SLC16A5extracellular space, cytosolOne of 2 routes

• maleateReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by SLC6A5, SLC26A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  3. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O

  Catalysed by GLYAT, GLYATL2, GLYATL1, GLYATL3 and 2 moremitochondrial matrixOne of 3 routes

• an alcoholReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 2 moremitochondrial matrix

• isocitric acidReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC6A5, SLC26A6, SLC25A1extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• glutarateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)

  Catalysed by GLYAT, GLYATL2, GLYATL1, BAAT and 1 moremitochondrial matrix, peroxisome, inner side of the membrane, outer side of the membraneOne of 2 routes

• (2R,3R)-tartrateReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by SLC6A5, SLC26A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by SLC6A5, SLC26A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by SLC6A5, SLC26A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by SLC6A5, SLC26A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes