dTTP

Three steps

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol

• dUMPReach from here →
  1. pyruvate kinase (dTDP)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. thymidine kinase (deoxyuridine)

  Catalysed by PKM, PKLRcytosolOne of 2 routes

• 2'-deoxyinosineReach from here →
  1. dTTP + H2O = thymidine + triphosphate + H(+)
  2. thymidine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + thymine
  3. 2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine

  Catalysed by SAMHD1, TYMP, PNP

• CHEBI:29052Reach from here →
  1. nucleoside-diphosphate kinase (dADP)
  2. dATP:D-fructose 6-phosphotransferase
  3. sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase

  Catalysed by NME4, NME6, NME1, NME2 and 7 morecytosol

• 3-methyl-1-hydroxybutylthiamine diphosphateReach from here →
  1. nucleoside-diphosphate kinase (dADP)
  2. Antiport of thiamine-diphosphate and dATP
  3. branched chain keto acid dehydrogenase E1 (4-methyl-2-oxopentanoate)

  Catalysed by NME4, NME6, NME1, NME2 and 5 morecytosol, mitochondrial matrix

• acetateReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 6 moreextracellular space, cytosolOne of 2 routes

• formic acidReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 6 moreextracellular space, cytosolOne of 2 routes

• propionic acidReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 7 moreextracellular space, cytosolOne of 2 routes

• butyric acidReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 7 moreextracellular space, cytosolOne of 2 routes

• maleateReach from here →
  1. pyruvate kinase (dTDP)
  2. transport of citrate and PEP (cytosol to mitochondria)
  3. maleate(in) + citrate(out) = maleate(out) + citrate(in)

  Catalysed by PKM, PKLR, SLC25A1cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. L-Serine:pyruvate aminotransferase

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosolOne of 2 routes

• 3-oxopropanoateReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol

• D-serineReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. D-serine = pyruvate + NH4(+)

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol

• N-acetylneuraminateReach from here →
  1. pyruvate kinase (dTDP)
  2. N-acetylneuraminate synthase
  3. N-acetylneuraminate 9-phosphate + H2O = N-acetylneuraminate + phosphate

  Catalysed by PKM, PKLR, NANS, NANPcytosol

• D-glucoseReach from here →
  1. nucleoside-diphosphate kinase (dADP)
  2. dATP:D-glucose 6-phosphotransferase
  3. D-Glucose-6-phosphate phosphohydrolase

  Catalysed by NME4, NME6, NME1, NME2 and 9 morecytosol, endoplasmic reticulum

• (R)-lactic acidReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol

• (S)-lactic acidReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. (S)-Lactate:NAD+ oxidoreductase

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 3 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• 2-iminopropanoateReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol

• N-acetyl-beta-neuraminic acidReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosolOne of 2 routes

• 2-methyl-1-hydroxypropylthiamine diphosphateReach from here →
  1. nucleoside-diphosphate kinase (dADP)
  2. Antiport of thiamine-diphosphate and dATP
  3. branched chain keto acid dehydrogenase E1 (3-methyl-2-oxobutyrate)

  Catalysed by NME4, NME6, NME1, NME2 and 5 morecytosol, mitochondrial matrix

• a 3-acylpyruvateReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol

• D-sedoheptulose 7-phosphateReach from here →
  1. nucleoside-diphosphate kinase (dADP)
  2. dATP:D-fructose 6-phosphotransferase
  3. sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase

  Catalysed by NME4, NME6, NME1, NME2 and 7 morecytosol

• N-acetyl-D-glucosamine 6-phosphateReach from here →
  1. nucleoside-diphosphate kinase (dADP)
  2. dATP:D-glucosamine 6-phosphotransferase
  3. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase

  Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol

• dCMPReach from here →
  1. DTTP Nucleotidohydrolase
  2. nucleoside-diphosphate kinase (dADP)
  3. cytidine/uridine monophosphate kinase (dADP)

  Catalysed by ENTPD3, ENTPD1, ENTPD8, NME4 and 6 moreextracellular space, cytosolOne of 20 routes

• beta-D-fructose 6-phosphateReach from here →
  1. nucleoside-diphosphate kinase (dADP)
  2. dATP:D-glucosamine 6-phosphotransferase
  3. alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)

  Catalysed by NME4, NME6, NME1, NME2 and 7 morecytosol

• dGMPReach from here →
  1. DTTP Nucleotidohydrolase
  2. nucleoside-diphosphate kinase (dADP)
  3. dADP to dATP conversion

  Catalysed by ENTPD3, ENTPD1, ENTPD8, NME4 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 4 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol

• 2-methyl-3-oxopropanoateReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol

• L-methionineReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 3 moreextracellular space, cytosol

• 6-phospho-D-glucono-1,5-lactoneReach from here →
  1. nucleoside-diphosphate kinase (dADP)
  2. dATP:D-glucose 6-phosphotransferase
  3. D-glucose-6-phosphate:NADP+ 1-oxidoreductase

  Catalysed by NME4, NME6, NME1, NME2 and 7 morecytosol, endoplasmic reticulumOne of 3 routes

• L-alanineReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 18 routes

• (2R)-3-phosphoglycerateReach from here →
  1. pyruvate kinase (dTDP)
  2. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  3. D-phosphoglycerate 2,3-phosphomutase

  Catalysed by PKM, PKLR, ENO1, ENO2 and 5 morecytosolOne of 3 routes

• 1D-myo-inositol 3-phosphateReach from here →
  1. nucleoside-diphosphate kinase (dADP)
  2. dATP:D-glucose 6-phosphotransferase
  3. 1D-myo-inositol-3-phosphate lyase (isomerizing)

  Catalysed by NME4, NME6, NME1, NME2 and 7 morecytosol

• (3S)-citramalyl-CoAReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol

• phosphoenolpyruvateReach from here →
  1. pyruvate kinase (dTDP)
  2. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  3. (2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O

  Catalysed by PKM, PKLR, ENO1, ENO2 and 2 morecytosolOne of 3 routes

• 5-amino-2-oxopentanoateReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol

• thiamine triphosphateReach from here →
  1. nucleoside-diphosphate kinase (dADP)
  2. Antiport of thiamine-diphosphate and dATP
  3. ATP:thiamine-diphosphate phosphotransferase

  Catalysed by NME4, NME6, NME1, NME2 and 4 morecytosol, mitochondrial matrix

• dCTPReach from here →
  1. nucleoside-diphosphate kinase (dADP)
  2. cytidine/uridine monophosphate kinase (dADP)
  3. ATP:dCDP phosphotransferase

  Catalysed by NME4, NME6, NME1, NME2 and 3 morecytosolOne of 11 routes

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol

• 2-deoxy-D-ribose 5-phosphateReach from here →
  1. dTTP + H2O = thymidine + triphosphate + H(+)
  2. thymidine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + thymine
  3. 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate

  Catalysed by SAMHD1, TYMP, PGM2

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol

• beta-citrylglutamateReach from here →
  1. pyruvate kinase (dTDP)
  2. transport of citrate and PEP (cytosol to mitochondria)
  3. citrate + L-glutamate + ATP = beta-citrylglutamate + ADP + phosphate + H(+)

  Catalysed by PKM, PKLR, SLC25A1, RIMKLBcytosol, mitochondrial matrix

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. DTTP Nucleotidohydrolase
  2. pyruvate kinase (dTDP)
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 4 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes