Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

thiamine triphosphate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

15 compounds within 3 steps: 2 in 1, 5 in 2, 8 in 3

Does it reach a compound?

One step

thiamine diphosphateReach from here →
1. thiamine triphosphate + H2O = thiamine diphosphate + phosphate + H(+)
Catalysed by THTPAOne of 2 routes
thiamine(1+) diphosphateReach from here →
1. Thiamin-triphosphate phosphohydrolase
Catalysed by THTPAcytosol

Two steps

CHEBI:16284Reach from here →
1. Thiamin-triphosphate phosphohydrolase
2. Antiport of thiamine-diphosphate and dATP
Catalysed by THTPA, SLC25A19cytosol, mitochondrial matrixOne of 2 routes
2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →
1. Thiamin-triphosphate phosphohydrolase
2. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)
Catalysed by THTPA, BCKDHA, BCKDHBcytosol, mitochondrial matrix

Three steps

alpha-D-glucosamine 6-phosphateReach from here →
Catalysed by THTPA, SLC25A19, HK1, HK2 and 1 morecytosol, mitochondrial matrix
keto-D-fructose 6-phosphateReach from here →

3-methyl-1-hydroxybutylthiamine diphosphate

Reach from here →

Thiamin-triphosphate phosphohydrolase
branched chain keto acid dehydrogenase E1 (4-methyl-2-oxopentanoate)

Catalysed by THTPA, BCKDHA, BCKDHBcytosol, mitochondrial matrix

2-methyl-1-hydroxypropylthiamine diphosphateReach from here →

Thiamin-triphosphate phosphohydrolase
branched chain keto acid dehydrogenase E1 (3-methyl-2-oxobutyrate)

Catalysed by THTPA, BCKDHA, BCKDHBcytosol, mitochondrial matrix

2-(1-hydroxyethyl)thiamine diphosphateReach from here →

Thiamin-triphosphate phosphohydrolase
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

Catalysed by THTPA, PDHA1, PDHB, PDHA2cytosol, mitochondrial matrix

Catalysed by THTPA, SLC25A19, HK1, HK2 and 2 more

cytosol, mitochondrial matrix

CHEBI:16174Reach from here →

Thiamin-triphosphate phosphohydrolase
Antiport of thiamine-diphosphate and dATP
ATP:dADP phosphotransferase

Catalysed by THTPA, SLC25A19, NME4, NME6 and 3 morecytosol, mitochondrial matrixOne of 20 routes

dTDPReach from here →

Thiamin-triphosphate phosphohydrolase
Antiport of thiamine-diphosphate and dATP
deoxythymidylate kinase (dADP)

Catalysed by THTPA, SLC25A19, DTYMKcytosol, mitochondrial matrixOne of 2 routes

dTTPReach from here →

Thiamin-triphosphate phosphohydrolase
Antiport of thiamine-diphosphate and dATP
nucleoside-diphosphate kinase (dADP)

Catalysed by THTPA, SLC25A19, NME4, NME6 and 4 morecytosol, mitochondrial matrixOne of 3 routes

CHEBI:28862Reach from here →

Thiamin-triphosphate phosphohydrolase
Antiport of thiamine-diphosphate and dATP
dADP to dATP conversion

Catalysed by THTPA, SLC25A19cytosol, mitochondrial matrix

D-glucopyranose 6-phosphateReach from here →

Thiamin-triphosphate phosphohydrolase
Antiport of thiamine-diphosphate and dATP
dATP:D-glucose 6-phosphotransferase

Catalysed by THTPA, SLC25A19, HK1, HK2 and 2 morecytosol, mitochondrial matrix

dCDPReach from here →

Thiamin-triphosphate phosphohydrolase
Antiport of thiamine-diphosphate and dATP
cytidine/uridine monophosphate kinase (dADP)

Catalysed by THTPA, SLC25A19, CMPK1cytosol, mitochondrial matrixOne of 2 routes