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2-methyl-1-hydroxypropylthiamine diphosphate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

15 compounds within 3 steps: 1 in 1, 5 in 2, 9 in 3

Does it reach a compound?

One step

thiamine(1+) diphosphateReach from here →
1. lipoamide to S-(2-methylpropanoyl)... conversion
Catalysed by DBT, BCKDHA, BCKDHBmitochondrial matrix

Two steps

CHEBI:16284Reach from here →
1. lipoamide to S-(2-methylpropanoyl)... conversion
2. Antiport of thiamine-diphosphate and dATP
Catalysed by DBT, BCKDHA, BCKDHB, SLC25A19mitochondrial matrix, cytosolOne of 2 routes
2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →
1. lipoamide to S-(2-methylpropanoyl)... conversion
2. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)
Catalysed by DBT, BCKDHA, BCKDHBmitochondrial matrix

Three steps

alpha-D-glucosamine 6-phosphateReach from here →
Catalysed by DBT, BCKDHA, BCKDHB, SLC25A19 and 3 moremitochondrial matrix, cytosol
keto-D-fructose 6-phosphateReach from here →

3-methyl-1-hydroxybutylthiamine diphosphate

Reach from here →

lipoamide to S-(2-methylpropanoyl)... conversion
branched chain keto acid dehydrogenase E1 (4-methyl-2-oxopentanoate)

Catalysed by DBT, BCKDHA, BCKDHBmitochondrial matrix

thiamine triphosphateReach from here →

lipoamide to S-(2-methylpropanoyl)... conversion
ATP:thiamine-diphosphate phosphotransferase

Catalysed by DBT, BCKDHA, BCKDHB, TPK1mitochondrial matrix, cytosol

2-(1-hydroxyethyl)thiamine diphosphateReach from here →

lipoamide to S-(2-methylpropanoyl)... conversion
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

Catalysed by DBT, BCKDHA, BCKDHB, PDHA1 and 2 moremitochondrial matrix

Catalysed by DBT, BCKDHA, BCKDHB, SLC25A19 and 4 more

mitochondrial matrix, cytosol

CHEBI:16174Reach from here →

lipoamide to S-(2-methylpropanoyl)... conversion
Antiport of thiamine-diphosphate and dATP
ATP:dADP phosphotransferase

Catalysed by DBT, BCKDHA, BCKDHB, SLC25A19 and 5 moremitochondrial matrix, cytosolOne of 20 routes

dTDPReach from here →

lipoamide to S-(2-methylpropanoyl)... conversion
Antiport of thiamine-diphosphate and dATP
deoxythymidylate kinase (dADP)

Catalysed by DBT, BCKDHA, BCKDHB, SLC25A19 and 1 moremitochondrial matrix, cytosolOne of 2 routes

dTTPReach from here →

lipoamide to S-(2-methylpropanoyl)... conversion
Antiport of thiamine-diphosphate and dATP
nucleoside-diphosphate kinase (dADP)

Catalysed by DBT, BCKDHA, BCKDHB, SLC25A19 and 6 moremitochondrial matrix, cytosolOne of 3 routes

CHEBI:28862Reach from here →

lipoamide to S-(2-methylpropanoyl)... conversion
Antiport of thiamine-diphosphate and dATP
dADP to dATP conversion

Catalysed by DBT, BCKDHA, BCKDHB, SLC25A19mitochondrial matrix, cytosol

D-glucopyranose 6-phosphateReach from here →

lipoamide to S-(2-methylpropanoyl)... conversion
Antiport of thiamine-diphosphate and dATP
dATP:D-glucose 6-phosphotransferase

Catalysed by DBT, BCKDHA, BCKDHB, SLC25A19 and 4 moremitochondrial matrix, cytosol

dCDPReach from here →

lipoamide to S-(2-methylpropanoyl)... conversion
Antiport of thiamine-diphosphate and dATP
cytidine/uridine monophosphate kinase (dADP)

Catalysed by DBT, BCKDHA, BCKDHB, SLC25A19 and 1 moremitochondrial matrix, cytosolOne of 2 routes

thiamine diphosphateReach from here →

lipoamide to S-(2-methylpropanoyl)... conversion
ATP:thiamine-diphosphate phosphotransferase
thiamine triphosphate + H2O = thiamine diphosphate + phosphate + H(+)

Catalysed by DBT, BCKDHA, BCKDHB, TPK1 and 1 moremitochondrial matrix, cytosolOne of 2 routes