Compound
2-methyl-1-hydroxypropylthiamine diphosphate
The diphosphate of thiamine(1+), substituted at C-2 of the thiazole ring by a hydroxylated sec-butyl group.
Definition from ChEBI (CHEBI:48522), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
3 entities
3 entities reached.
What the reference databases state
Statements
3 statements
3 statements · 1 reference database · Subject: 2-methyl-1-hydroxypropylthiamine diphosphate · Sources: Human-GEM
- 2-methyl-1-hydroxypropylthiamine diphosphate is a substrate of BCKDHAProteinHuman-GEM MAR06416Inferred only
- 2-methyl-1-hydroxypropylthiamine diphosphate is a substrate of BCKDHBProteinHuman-GEM MAR06416Inferred only
- 2-methyl-1-hydroxypropylthiamine diphosphate is a substrate of DBTProteinHuman-GEM MAR06416Inferred only
Reactions
2 reactions
MAM02393m+2-methyl-1-hydroxypropylthiamine diphosphateMAM02857m+thiamine(1+) diphosphate
Catalysed by DBT & BCKDHA & BCKDHB
Reaction pageLeft to rightBalance undeterminableEC 1.2.4.4GO:0005759
Human-GEM MAR06416CC BY 4.0Reference data
3-methyl-2-oxobutanoate+proton+thiamine(1+) diphosphatecarbon dioxide+2-methyl-1-hydroxypropylthiamine diphosphate
Reaction pageLeft to rightBalance undeterminableEC 1.2.4.4GO:0005759
Human-GEM MAR20174CC BY 4.0Reference data
Other names
8 names
Resolves to: 2-methyl-1-hydroxypropylthiamine diphosphate
- Also called
- 1-hydroxy-2-methylpropyl-thiamine diphosphate1-hydroxy-2-methylpropyl-thiamine pyrophosphate2-methyl-1-hydroxypropyl-thiamine diphosphate2-methyl-1-hydroxypropyl-thiamine pyrophosphate2-Methyl-1-hydroxypropyl-ThPP2-Methyl-1-hydroxypropyl-TPP3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-diphosphoethyl)-2-(1-hydroxy-2-methylpropyl)-4-methyl-1,3-thiazol-3-ium
- Systematic name
- 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxy-2-methylpropyl)-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium