L-isoleucine

1. transport of glycine and isoleucine (cytosol to extracellular)
2. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

Catalysed by SLC7A5, BAATextracellular space, cytosol

1. transport of glutamine and isoleucine (cytosol to extracellular)
2. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

Catalysed by SLC7A5, GLYATL1B, GLYATL1extracellular space, cytosol

1. Acetylation of Isoleucine
2. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moremitochondrial matrix, cytosolOne of 8 routes

1. Acetylation of Isoleucine
2. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moremitochondrial matrix, cytosolOne of 4 routes

1. transport of isoleucine and tyrosine (cytosol to extracellular)
2. L-tyrosine:2-oxoglutarate aminotransferase
3. (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + NADH + H(+)

Catalysed by SLC7A5, GOT2, GOT1, TAT and 1 moreextracellular space, cytosol

1. transport of alanine and isoleucine (cytosol to extracellular)
2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
3. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)