3-fumarylpyruvate

Three steps

• glutathione disulfideReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. transport of fumarate and thiosulfate (cytosol to mitochondria)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by FAHD1, SLC25A10, TSTD1mitochondrial matrix, cytosol

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by FAHD1, AGXT2mitochondrial matrixOne of 7 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by FAHD1, AGXT2, SLC1A4mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• kynurenateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O

  Catalysed by FAHD1, MPST, AADATOne of 2 routes

• 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by FAHD1, ADSLcytosolOne of 2 routes

• N(8)-acetylspermidineReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(8)-acetylspermidine + H2O = spermidine + acetate

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

• (S)-3-amino-2-methylpropanoateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-3-amino-isobutanoate:2-oxoglutarate aminotransferase

  Catalysed by FAHD1, AGXT2, ABATmitochondrial matrix

• phosphoenolpyruvateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. Pyruvate:carbon-dioxide ligase (ADP-forming)
  3. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2

  Catalysed by FAHD1, PC, PCK1, PCK2mitochondrial matrix

• an N-acetyl-L-cysteine-S-conjugateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

• L-methionine (S)-S-oxideReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by FAHD1, TYW1B, TYW1, MSRA

• L-methionine (R)-S-oxideReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by FAHD1, TYW1B, TYW1, MSRB3 and 2 more

• S-sulfanylglutathioneReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. transport of fumarate and thiosulfate (cytosol to mitochondria)
  3. thiosulfate + glutathione = S-sulfanylglutathione + sulfite + H(+)

  Catalysed by FAHD1, SLC25A10, TSTD1mitochondrial matrix, cytosolOne of 3 routes

• (2S)-2-phospholactateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate

  Catalysed by FAHD1, LDHA, LDHB, LDHC and 3 moreOne of 2 routes

• L-prolineReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by FAHD1, AGXT2, SLC1A4mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• estrone 3-sulfateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. estrone 3-sulfate + H2O = estrone + sulfate + H(+)

  Catalysed by FAHD1, SLC25A10, STSmitochondrial matrix, cytosol

• prostaglandin E2Reach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)

  Catalysed by FAHD1, LDHA, LDHB, LDHC and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• L-cysteinylglycineReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by FAHD1, AGXT2, GGTLC3, GGT1 and 4 moremitochondrial matrix, cytosolOne of 2 routes

• (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. a quinone + succinate = fumarate + a quinol
  3. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)

  Catalysed by FAHD1, SDHB, PRODH2

• (5-hydroxyindol-3-yl)acetateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. Transport of 5-Hydroxyindoleacetate

  Catalysed by FAHD1, SLC25A10, SLC4A1mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• dTMPReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. pyruvate kinase (dTDP)
  3. DTDP Diphosphohydrolase

  Catalysed by FAHD1, PKM, PKLR, ENTPD3 and 2 morecytosol, extracellular spaceOne of 5 routes

• ubiquinol-10Reach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate

  Catalysed by FAHD1, SLC25A10, SQORmitochondrial matrix, cytosol

• Mo-molybdopterinReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by FAHD1, AGXT2, MOCOSmitochondrial matrix

• (2S)-2-aminobutanoateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by FAHD1, AGXT2mitochondrial matrixOne of 6 routes

• 2-iminobutanoateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)

  Catalysed by FAHD1, AGXT2, RIDA

• 2-aminoprop-2-enoateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. D-serine = pyruvate + NH4(+)
  3. D-serine = 2-aminoprop-2-enoate + H2O

  Catalysed by FAHD1, SRR

• thromboxane B2Reach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. thromboxane B2(out) + 2 (S)-lactate(in) = thromboxane B2(in) + 2 (S)-lactate(out)

  Catalysed by FAHD1, LDHA, LDHB, LDHC and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• thiamine(1+) diphosphateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
  3. 2-(alpha-hydroxyethyl)thiamine-diphosphate[m] + lipoamide[m] = S-acetyldihydrolipoamide[m] + thiamin-PP[m]

  Catalysed by FAHD1, PDHA1, PDHB, PDHA2 and 1 moremitochondrial matrix