1,2-diacyl-sn-glycero-3-phosphocholine(1+)

Three steps

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by PTDSS1, CHDH, TBXAS1, PTGS2 and 1 morecytosol

• (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 17 moreendoplasmic reticulum, extracellular space

• (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 17 moreendoplasmic reticulum, extracellular space

• (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 moreendoplasmic reticulum, extracellular space

• leukotriene A4Reach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = leukotriene A4 + H2O

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 moreendoplasmic reticulum, extracellular space

• (13S)-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. Linoleate:oxygen 13-oxidoreductase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 moreendoplasmic reticulum, extracellular space, cytosol

• (R)-2-hydroxyoctadecanoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. octadecanoate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 moreendoplasmic reticulum, extracellular space

• sn-glycerol 3-phosphateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 24 moreendoplasmic reticulum, cytosol

• ethanolamineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. Phsophatidyl-L-serine carboxy-lyase
  3. L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase

  Catalysed by PTDSS1, PISD, PTDSS2cytosolOne of 3 routes

• an N-acylsphing-4-enine 1-phosphateReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acylsphing-4-enine + ATP = an N-acylsphing-4-enine 1-phosphate + ADP + H(+)

  Catalysed by SGMS1, SGMS2, AGK, CERKGolgi apparatus

• guanidinoacetateReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by PTDSS1, SLC5A7cytosol, extracellular space

• sphing-4-enineReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 moreendoplasmic reticulum, cytosol, Golgi apparatusOne of 6 routes

• sphinganineReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. N-acylsphingosine amidohydrolase
  3. an N-acylsphinganine + H2O = sphinganine + a fatty acid

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 moreendoplasmic reticulum, cytosolOne of 2 routes

• spermidineReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 20 moreendoplasmic reticulum, cytosolOne of 3 routes

• L-methionineReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 7 routes

• a 2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by SGMS1, SGMS2, LPGAT1Golgi apparatusOne of 14 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphate(out) + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phosphate(in) + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)

  Catalysed by SGMS1, SGMS2, DGKI, DGKA and 10 moreGolgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-tryptophanReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Tryptophan by Atb0 Transporter

  Catalysed by PTDSS1, SLC5A7, SLC6A14cytosol, extracellular spaceOne of 2 routes

• beta-alanineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by PTDSS1, SLC5A7, SLC6A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• a 1-acyl-sn-glycero-3-phosphateReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)
  3. a 1-acyl-sn-glycero-3-phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate

  Catalysed by SGMS1, SGMS2, DGKI, DGKA and 10 moreGolgi apparatus

• L-alanineReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 18 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 5 routes

• L-asparagineReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 3 routes

• glycerol 2-phosphateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. Glycerophosphocholine Phosphodiesterase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 23 moreendoplasmic reticulum, cytosol

• L-phenylalanineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Phenylalanine by Atb0 Transporter

  Catalysed by PTDSS1, SLC5A7, SLC6A14cytosol, extracellular spaceOne of 2 routes

• L,L-cystathionineReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 moreendoplasmic reticulum, cytosol, mitochondrial matrix

• a 1-acyl-sn-glycero-3-phosphocholineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

  Catalysed by SGMS1, SGMS2, PLA2G10, PLA2G6 and 28 moreGolgi apparatusOne of 14 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)Reach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)

  Catalysed by LCAT, CES1, LIPN, NCEH1 and 2 morecytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• phosphoethanolamineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = phosphoethanolamine + a 1,2-diacyl-sn-glycerol + H(+)

  Catalysed by SGMS1, SGMS2, SELENOI, CEPT1 and 1 moreGolgi apparatus

• a CDP-1,2-diacyl-sn-glycerolReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate

  Catalysed by SGMS1, SGMS2, DGKI, DGKA and 12 moreGolgi apparatus

• an acyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 moreendoplasmic reticulum, cytosol, Golgi apparatusOne of 6 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)Reach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(in) + cholesterol(out)

  Catalysed by LCAT, CES1, LIPN, NCEH1 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 20 moreendoplasmic reticulum, cytosolOne of 3 routes

• CDP-cholineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. phosphocholine + H2O = choline + phosphate
  3. phosphocholine + CTP + H(+) = CDP-choline + diphosphate

  Catalysed by PTDSS1, PHOSPHO1, PCYT1A, PCYT1BcytosolOne of 2 routes

• deoxycholoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 20 moreendoplasmic reticulum, cytosolOne of 4 routes

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 moreendoplasmic reticulum, extracellular space

• 4-aminobutanoateReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by PTDSS1, SLC5A7, SLC6A12cytosol, extracellular spaceOne of 4 routes

• (9S)-hydroperoxy-(10E,12Z)-octadecadienoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. linoleate:oxygen 9-oxidoreductase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 14 moreendoplasmic reticulum, extracellular space, cytosol

• decanoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 24 moreendoplasmic reticulum, cytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 moreendoplasmic reticulum, cytosolOne of 6 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 moreendoplasmic reticulum, cytosolOne of 16 routes

• a cardiolipinReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by SGMS1, SGMS2, TAFAZZINGolgi apparatus

• an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acyl-sn-glycero-3-phosphocholine + H(+)

  Catalysed by SGMS1, SGMS2, PLA2G4E, PLAAT5 and 1 moreGolgi apparatusOne of 4 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 20 moreendoplasmic reticulum, cytosol

• CHEBI:63544Reach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 moreendoplasmic reticulum, cytosolOne of 9 routes

• 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. cytochrome P450 (arachidonate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 moreendoplasmic reticulum, extracellular spaceOne of 2 routes

• (4R)-hydroxysphinganineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol
  3. Phytoceramide amidohydrolase

  Catalysed by SGMS1, SGMS2, ASAH1, ACER2 and 3 moreGolgi apparatus, cytosolOne of 2 routes

• a 1-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine

  Catalysed by SGMS1, SGMS2, SELENOI, CEPT1 and 1 moreGolgi apparatusOne of 2 routes

• hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+)

  Catalysed by SGMS1, SGMS2, PLAAT3, PLAAT1Golgi apparatusOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)

  Catalysed by SGMS1, SGMS2, SELENOI, CEPT1 and 1 moreGolgi apparatus