a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

329 compounds within 3 steps: 5 in 1, 59 in 2, 265 in 3

One step

cholesterolReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(in) + cholesterol(out)
Catalysed by OSBP2, OSBPL2inner side of the membrane, outer side of the membraneOne of 2 routes
a 1,2-diacyl-sn-glycerolReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)
Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 9 more
1D-myo-inositol 1,4,5-trisphosphateReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)
Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 9 more
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)Reach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
Catalysed by PIP4P1, PIP4P2
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)Reach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate
Catalysed by SYNJ2, SYNJ1, INPP5B, OCRL and 5 more

Two steps

inner side of the membrane, outer side of the membrane

cholesterol sulfateReach from here →

Catalysed by OSBP2, OSBPL2, SULT2B1, SULT1C2inner side of the membrane, outer side of the membrane

(11Z,14Z,17Z-eicosatrienoyl)-cholesterolReach from here →

Catalysed by OSBP2, OSBPL2, LCATinner side of the membrane, outer side of the membrane

cholesteryl (7Z)-octadecenoateReach from here →

Catalysed by OSBP2, OSBPL2, SOAT1inner side of the membrane, outer side of the membrane

phosphatidylethanolamineReach from here →

Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 11 morecytosol

1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →

Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 11 morecytosol

phosphatidic acidReach from here →

Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 11 morenucleusOne of 2 routes

pregnenoloneReach from here →

Catalysed by OSBP2, OSBPL2, CYP11A1inner side of the membrane, outer side of the membrane

1-phosphatidyl-1D-myo-inositolReach from here →

Catalysed by SYNJ2, SYNJ1, INPP5B, OCRL and 17 morecytosolOne of 6 routes

a cholesterol esterReach from here →

Catalysed by OSBP2, OSBPL2, SOAT2, SOAT1inner side of the membrane, outer side of the membrane

a 2-acylglycerolReach from here →

Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 12 more

a monoacylglycerolReach from here →

Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 24 moreextracellular spaceOne of 8 routes

cholesteryl 3-beta-D-glucosideReach from here →

Catalysed by OSBP2, OSBPL2, GBA1, GBA2inner side of the membrane, outer side of the membraneOne of 7 routes

7alpha-hydroxycholesterolReach from here →

Catalysed by OSBP2, OSBPL2, CYP7A1inner side of the membrane, outer side of the membrane

26-hydroxycholesterolReach from here →

Catalysed by OSBP2, OSBPL2, CYP3A4inner side of the membrane, outer side of the membrane

a triacylglycerolReach from here →

Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 14 morecytosol

4-methylpentanalReach from here →

Catalysed by OSBP2, OSBPL2, CYP11A1inner side of the membrane, outer side of the membrane

cholesteryl 3-beta-D-galactosideReach from here →

Catalysed by OSBP2, OSBPL2, GBA1, GBA2inner side of the membrane, outer side of the membraneOne of 2 routes

cholesteryl 3-beta-D-xylosideReach from here →

Catalysed by OSBP2, OSBPL2, GBA1, GBA3inner side of the membrane, outer side of the membraneOne of 2 routes

a fatty acidReach from here →

Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 12 more

an N-acylsphinganineReach from here →

Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 11 more

an N-acyl-(4R)-4-hydroxysphinganineReach from here →

Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 11 more

(24S)-hydroxycholesterolReach from here →

Catalysed by OSBP2, OSBPL2, CYP46A1inner side of the membrane, outer side of the membrane

fatty acidReach from here →

Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 10 moreextracellular spaceOne of 7 routes

cholesteryl hexadecanoateReach from here →

Catalysed by OSBP2, OSBPL2, SOAT1inner side of the membrane, outer side of the membrane

cholesteryl (9Z,12Z)-octadecadienoateReach from here →

Catalysed by OSBP2, OSBPL2, SOAT1inner side of the membrane, outer side of the membraneOne of 2 routes

25-hydroxycholesterolReach from here →

Catalysed by OSBP2, OSBPL2, CH25Hinner side of the membrane, outer side of the membraneOne of 3 routes

N-octanoylsphing-4-enineReach from here →

Catalysed by OSBP2, OSBPL2, GBA1inner side of the membrane, outer side of the membrane

cholesteryl (9Z-octadecenoate)Reach from here →

Catalysed by OSBP2, OSBPL2, SOAT2, SOAT1inner side of the membrane, outer side of the membraneOne of 2 routes

(24R)-hydroxycholesterolReach from here →

Catalysed by OSBP2, OSBPL2, CYP3A4inner side of the membrane, outer side of the membrane

an N-acylsphing-4-enineReach from here →

Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 11 moreOne of 4 routes

a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →

Catalysed by SYNJ2, SYNJ1, INPP5B, OCRL and 11 moreinner side of the membrane, outer side of the membraneOne of 2 routes

a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →

Catalysed by SYNJ2, SYNJ1, INPP5B, OCRL and 6 moreinner side of the membrane, outer side of the membraneOne of 8 routes

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →

Catalysed by SYNJ2, SYNJ1, INPP5B, OCRL and 7 moreOne of 2 routes

a 1,2-diacyl-sn-glycero-3-phosphateReach from here →

Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 20 more

a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →

Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 11 more

a triacyl-sn-glycerolReach from here →

Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 15 more

N-hexadecanoyl-(4R)-hydroxysphinganineReach from here →

Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 11 more

N-hexadecanoylsphinganineReach from here →

Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 11 more

(22R)-hydroxycholesterolReach from here →

Catalysed by OSBP2, OSBPL2, CYP11A1inner side of the membrane, outer side of the membraneOne of 2 routes

N-dodecanoylsphing-4-enineReach from here →

Catalysed by OSBP2, OSBPL2, GBA1, GBA2inner side of the membrane, outer side of the membraneOne of 2 routes

N-hexadecanoylsphing-4-enineReach from here →

Catalysed by OSBP2, OSBPL2, GBA1inner side of the membrane, outer side of the membrane

N-octadecanoylsphing-4-enineReach from here →

Catalysed by OSBP2, OSBPL2, GBA1inner side of the membrane, outer side of the membrane

1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →

Catalysed by OSBP2, OSBPL2, LCATinner side of the membrane, outer side of the membraneOne of 9 routes