(4R)-hydroxysphinganine

1. Sphingosine Kinase 1

Catalysed by SPHK1cytosolOne of 2 routes

1. (4R)-hydroxysphinganine + hexadecanoyl-CoA = N-hexadecanoyl-(4R)-hydroxysphinganine + CoA + H(+)

Catalysed by CERS6, CERS5

1. N-dodecanoyl-(4R)-hydroxysphinganine + H2O = (4R)-hydroxysphinganine + dodecanoate

Catalysed by ASAH1

1. Sphingosine Kinase 1
2. Sphingosine-1-Phosphate Lyase 1 (Phytosphingosine-1-Phosphate, Cytosol)

Catalysed by SPHK1cytosol

1. (4R)-hydroxysphinganine + hexadecanoyl-CoA = N-hexadecanoyl-(4R)-hydroxysphinganine + CoA + H(+)
2. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol

Catalysed by CERS6, CERS5, SGMS1, SGMS2One of 2 routes

1. (4R)-hydroxysphinganine + hexadecanoyl-CoA = N-hexadecanoyl-(4R)-hydroxysphinganine + CoA + H(+)
2. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol
3. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

Catalysed by CERS6, CERS5, SGMS1, SGMS2 and 5 morecytosol

1. Sphingosine Kinase 1
2. Sphingosine-1-Phosphate Lyase 1 (Phytosphingosine-1-Phosphate, Cytosol)
3. ethanolamine-phosphate phosphate-lyase (deaminating