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Proteins/UNIPROT:Q9NXG6
Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex..
Function from UniProtKB (Q9NXG6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
261 statements
261 statements · 4 reference databases · Subject: P4HTM · Sources: gene ontology, Hetionet, UniProt, WikiPathways
1 reaction
L-prolyl-[hypoxia-inducible factor alpha subunit]+2-oxoglutarate(2-)+dioxygentrans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]+succinate(2-)+carbon dioxide
Catalysed by EGLN2 or EGLN1 or EGLN3 or P4HTM
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:48400CC BY 4.0Reference data
6 names
Resolves to: P4HTM