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Proteins/UNIPROT:P54577
Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity. Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1..
Function from UniProtKB (P54577), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
3 rows
184 statements
184 statements · 7 reference databases · Subject: YARS1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
ATP+MAM03081c+CHEBI:17895AMP+MAM02421c+diphosphate(3-)
Catalysed by YARS1
Reaction pageLeft to rightBalance undeterminableEC 6.1.1.1cytosol
Human-GEM MAR05130CC BY 4.0Reference data
CHEBI:78442+L-tyrosine+ATP(4-)CHEBI:78536+AMP+diphosphate(3-)+
4 names
Resolves to: YARS1
Reaction pageLeft to rightBalanced
Rhea RHEA:10220CC BY 4.0Reference data