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Proteins/UNIPROT:Q9NRP7
Serine/threonine protein kinase which plays an important role in the smoothened pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. Acts by mediating phosphorylation of GLI proteins, promoting their dissociation from SUFU. Also catalyzes phosphorylation of ULK4 adapter. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia..
Function from UniProtKB (Q9NRP7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
45 statements
45 statements · 4 reference databases · Subject: STK36 · Sources: gene ontology, Hetionet, UniProt, WikiPathways
2 reactions
2 names
Resolves to: STK36
Rhea RHEA:17989CC BY 4.0Reference data