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Proteins/UNIPROT:Q53H47
Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Also has kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining. Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A..
Function from UniProtKB (Q53H47), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
214 statements
214 statements · 4 reference databases · Subject: SETMAR · Sources: gene ontology, Hetionet, UniProt, WikiPathways
8 reactions
3 names
Resolves to: SETMAR
Reaction pageReversibleBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR04241CC BY 4.0Reference data
MAM00204c+S-adenosyl-L-methionineMAM00213c+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C or SETDB2 or SETD1B and 11 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354cytosol
Human-GEM MAR06975CC BY 4.0Reference data
MAM00213c+S-adenosyl-L-methionineMAM00212c+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C or SETDB2 or SETD1B and 11 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354cytosol
Human-GEM MAR06976CC BY 4.0Reference data
MAM00212c+S-adenosyl-L-methionineMAM00211c+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C or SETDB2 or SETD1B and 11 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354cytosol
Human-GEM MAR06977CC BY 4.0Reference data
MAM00204n+S-adenosyl-L-methionineproton+MAM02129n+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or EZH2 or EZH1 or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR08025CC BY 4.0Reference data
MAM02129n+S-adenosyl-L-methionineMAM00212n+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or EZH2 or EZH1 or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR08026CC BY 4.0Reference data
MAM00212n+S-adenosyl-L-methionineMAM00211n+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or EZH2 or EZH1 or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR08027CC BY 4.0Reference data
L-lysyl(36)-[histone H3]+2S-adenosyl-L-methionineN(6),N(6)-dimethyl-L-lysyl(36)-[histone H3]+2S-adenosyl-L-homocysteine+2hydron
Catalysed by NSD2 or SETMAR or NSD1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:60308CC BY 4.0Reference data